Gene: APOL5

80831
APOL-V|APOLV
apolipoprotein L5
protein-coding
22q12.3
Ensembl:ENSG00000128313 MIM:607255 Vega:OTTHUMG00000150588 UniprotKB:Q9BWW9
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.570e-1 (AD)  2.049e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs5999984chr22:35724463 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRLHR0.648
SLC10A40.648
HAPLN10.64
RELN0.64
PTHLH0.632
VIP0.628
IGF10.62
DLX10.613
CHRNA60.611
SSTR40.609

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.395
TGFB3-0.385
CSAG1-0.381
AQP1-0.378
CTNNA3-0.363
ROM1-0.352
LPAR1-0.351
HBA2-0.35
GABRE-0.349
MYOT-0.348

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of APOL5 mRNA"23146750
D002104CadmiumCadmium results in decreased expression of APOL5 mRNA24376830
D010936Plant ExtractsPlant Extracts results in decreased expression of APOL5 mRNA23557933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008035high-density lipoprotein particle binding-NAS11374903  
GO:0008289lipid binding-IBA21873635  
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-NAS11374903  
GO:0006869lipid transport-IEA-  
GO:0042157lipoprotein metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal