Gene: KMT2D

8085
AAD10|ALR|CAGL114|KABUK1|KMS|MLL2|MLL4|TNRC21
lysine methyltransferase 2D
protein-coding
12q13.12
Ensembl:ENSG00000167548 MIM:602113 Vega:OTTHUMG00000166524 UniprotKB:O14686
NG_027827.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.814e-1 (AD)  9.776e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRRAP0.932
UBR40.91
SRCAP0.908
SETD1B0.905
EP4000.9
TNRC6C0.895
NSD10.892
HERC20.883
ANKRD520.883
CREBBP0.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.465
OR4F29-0.421
KLRC2-0.362
KLRC3-0.354
ODAM-0.348
COPZ2-0.343
IRX5-0.335
IL20RA-0.33
SH2D1A-0.324
GSDMC-0.322

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of KMT2D mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KMT2D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KMT2D mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of KMT2D mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KMT2D gene27153756
D001280AtrazineAtrazine results in decreased expression of KMT2D mRNA23358194
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of KMT2D exon26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of KMT2D gene25435355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KMT2D mRNA"19150397|2001819
D004958EstradiolEstradiol promotes the reaction [KMT2D protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol results in increased expression of KMT2D mRNA23019147
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol results in increased acetylation of EZH2 promoter]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol results in increased expression of EZH2 mRNA]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol results in increased methylation of EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [KMT2D protein binds to EZH2 promoter]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A results in increased acetylation of EZH2 promoter]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A results in increased expression of EZH2 mRNA]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A results in increased methylation of EZH2 promoter]25088689
C006780bisphenol Abisphenol A affects the methylation of KMT2D promoter27334623
C006780bisphenol Abisphenol A affects the expression of KMT2D mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of KMT2D mRNA26079696
D003375CoumestrolCoumestrol results in decreased expression of KMT2D mRNA19167446
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KMT2D mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of KMT2D mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of KMT2D mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [KMT2D protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol results in increased acetylation of EZH2 promoter]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol results in increased expression of EZH2 mRNA]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol results in increased methylation of EZH2 promoter]25088689
C010974glyphosateglyphosate results in increased expression of KMT2D mRNA26302742
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KMT2D mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KMT2D mRNA"27188386
D015735MifepristoneMifepristone results in decreased expression of KMT2D mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KMT2D mRNA"25554681
C025256nonylphenolnonylphenol results in increased expression of KMT2D mRNA22982499
C057693troglitazonetroglitazone results in decreased expression of KMT2D mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of KMT2D mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of KMT2D mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-NAS9247308  
GO:0003713transcription coactivator activity-IBA21873635  
GO:0005515protein binding-IPI16603732  22722839  26886794  
GO:0018024histone-lysine N-methyltransferase activity-TAS-  
GO:0042393histone binding-IBA21873635  
GO:0042800histone methyltransferase activity (H3-K4 specific)-IBA21873635  
GO:0042800histone methyltransferase activity (H3-K4 specific)-TAS-  
GO:0044212transcription regulatory region DNA binding-IDA16603732  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001555oocyte growth-ISS-  
GO:0006342chromatin silencing-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS9247308  
GO:0008284positive regulation of cell proliferation-IMP16603732  
GO:0033148positive regulation of intracellular estrogen receptor signaling pathway-IMP16603732  
GO:0043627response to estrogen-IDA16603732  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP16603732  
GO:0048477oogenesis-ISS-  
GO:0051568histone H3-K4 methylation-ISS17178841  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS9247308  
GO:0005654nucleoplasm-TAS-  
GO:0035097histone methyltransferase complex-IPI14992727  
GO:0044666MLL3/4 complex-IBA21873635  
GO:0044666MLL3/4 complex-IDA17500065  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26900290Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. (2016 Feb 21)Sasaki YWorld J Gastroenterol