Gene info: ID 8086

Gene: AAAS

GENE ID: 8086

Description: aladin WD repeat nucleoporin

Gene type: protein-coding

Location: 12q13.13

dbXrefs: Ensembl:ENSG00000094914 MIM:605378 Vega:OTTHUMG00000169729 UniprotKB:Q9NRG9

RefSeq: NG_016775.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 33

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.479e-1 (AD) 6.837e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RBM10	0.894
NAT9	0.892
GGA1	0.889
AKT2	0.884
SNRNP70	0.883
CXXC1	0.88
TRMT1	0.88
GMPPA	0.878
KAT2A	0.877
TMEM161A	0.877

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.685
OR4F29	-0.667
FER1L6	-0.307
GSDMA	-0.301
ARHGEF35	-0.3
GADL1	-0.282
PPP1R3A	-0.281
C10orf71	-0.279
DPPA4	-0.274
SDR42E1	-0.269

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of AAAS mRNA"	22101062
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AAAS mRNA"	19167446
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of AAAS mRNA"	21346803
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of AAAS mRNA"	21346803
D020106	Acrylamide	Acrylamide results in increased expression of AAAS mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of AAAS mRNA	19770486
D001280	Atrazine	Atrazine results in increased expression of AAAS mRNA	25929836
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of AAAS mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of AAAS mRNA	27858113
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of AAAS mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AAAS mRNA	19770486\|2171566
C006780	bisphenol A	bisphenol A results in increased expression of AAAS mRNA	25181051
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of AAAS mRNA	27858113
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of AAAS mRNA	19320972
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AAAS mRNA"	19167446
D003375	Coumestrol	Coumestrol results in increased expression of AAAS mRNA	19167446
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of AAAS mRNA	17361019
D004041	Dietary Fats	Dietary Fats results in increased expression of AAAS mRNA	25016146
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of AAAS mRNA	21607683
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AAAS protein	23301498
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of AAAS mRNA	21607683
C069837	fullerene C60	fullerene C60 results in increased expression of AAAS mRNA	19167457
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of AAAS mRNA	22634610
C089796	hexabromocyclododecane	hexabromocyclododecane affects the expression of AAAS mRNA	24680724
D017313	Fenretinide	Fenretinide results in increased expression of AAAS mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AAAS mRNA	25613284
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of AAAS mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of AAAS mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of AAAS mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in increased expression of AAAS mRNA	19167457
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of AAAS mRNA	25729387
D010269	Paraquat	AAAS protein affects the susceptibility to Paraquat	23315990
D010634	Phenobarbital	Phenobarbital affects the expression of AAAS mRNA	23091169
D010672	Phenytoin	Phenytoin results in decreased expression of AAAS mRNA	20345932
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of AAAS mRNA	22484513
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AAAS mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of AAAS mRNA	23811191
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of AAAS mRNA	21427059
D012715	Sesame Oil	Sesame Oil results in increased expression of AAAS mRNA	29191790
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of AAAS mRNA	21570461\|2468072
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AAAS mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of AAAS mRNA	25729387
C012589	trichostatin A	trichostatin A results in increased expression of AAAS mRNA	15901671
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of AAAS mRNA	19042947
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of AAAS mRNA	21346803
D014635	Valproic Acid	Valproic Acid results in increased expression of AAAS mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in increased expression of AAAS mRNA	21427059

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003674	molecular_function	-	ND	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006406	mRNA export from nucleus	-	TAS	-
GO:0006913	nucleocytoplasmic transport	-	IBA	21873635
GO:0006913	nucleocytoplasmic transport	-	IDA	12730363
GO:0007612	learning	-	IEA	-
GO:0009566	fertilization	-	IEA	-
GO:0016032	viral process	-	TAS	-
GO:0046822	regulation of nucleocytoplasmic transport	-	NAS	12730363

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005635	nuclear envelope	-	TAS	-
GO:0005643	nuclear pore	-	IBA	21873635
GO:0005643	nuclear pore	-	IDA	12730363
GO:0005643	nuclear pore	colocalizes_with	IDA	12730363
GO:0005654	nucleoplasm	-	IDA	-
GO:0005813	centrosome	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0016020	membrane	-	HDA	19946888
GO:0031965	nuclear membrane	-	IDA	-

KEGG ID	KEGG Term
hsa03013	RNA transport

Reactome ID	Reactome Term	Evidence
R-HSA-1169408	ISG15 antiviral mechanism	TAS
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-159227	Transport of the SLBP independent Mature mRNA	TAS
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	TAS
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	TAS
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	TAS
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	TAS
R-HSA-162587	HIV Life Cycle	TAS
R-HSA-162599	Late Phase of HIV Life Cycle	TAS
R-HSA-162906	HIV Infection	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-162909	Host Interactions of HIV factors	IEA
R-HSA-162909	Host Interactions of HIV factors	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1643685	Disease	IEA
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	TAS
R-HSA-168253	Host Interactions with Influenza Factors	TAS
R-HSA-168254	Influenza Infection	TAS
R-HSA-168255	Influenza Life Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	TAS
R-HSA-168273	Influenza Viral RNA Transcription and Replication	TAS
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	TAS
R-HSA-168276	NS1 Mediated Effects on Host Pathways	TAS
R-HSA-168325	Viral Messenger RNA Synthesis	TAS
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	TAS
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	TAS
R-HSA-176033	Interactions of Vpr with host cellular proteins	TAS
R-HSA-177243	Interactions of Rev with host cellular proteins	IEA
R-HSA-177243	Interactions of Rev with host cellular proteins	TAS
R-HSA-180746	Nuclear import of Rev protein	IEA
R-HSA-180910	Vpr-mediated nuclear import of PICs	TAS
R-HSA-191859	snRNP Assembly	TAS
R-HSA-194441	Metabolism of non-coding RNA	TAS
R-HSA-211000	Gene Silencing by RNA	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2980766	Nuclear Envelope Breakdown	TAS
R-HSA-2990846	SUMOylation	TAS
R-HSA-2990846	SUMOylation	IEA
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	TAS
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	TAS
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	IEA
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	TAS
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-4551638	SUMOylation of chromatin organization proteins	TAS
R-HSA-4570464	SUMOylation of RNA binding proteins	TAS
R-HSA-4615885	SUMOylation of DNA replication proteins	IEA
R-HSA-4615885	SUMOylation of DNA replication proteins	TAS
R-HSA-5578749	Transcriptional regulation by small RNAs	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-5663205	Infectious disease	IEA
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-597592	Post-translational protein modification	IEA
R-HSA-6784531	tRNA processing in the nucleus	TAS
R-HSA-68875	Mitotic Prophase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-70171	Glycolysis	TAS
R-HSA-70326	Glucose metabolism	TAS
R-HSA-71387	Metabolism of carbohydrates	TAS
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	TAS
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	TAS
R-HSA-72306	tRNA processing	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-913531	Interferon Signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17398058	Cigarette smoking increases aortic dilatation without affecting matrix metalloproteinase-9 and -12 expression in a modified mouse model of aneurysm formation. (2007 Jun)	Bergoeing MP	J Vasc Surg
29628493	Effect of a High-sucrose Diet on Abdominal Aortic Aneurysm Development in a Hypoperfusion-induced Animal Model. (2018 May 1)	Miyamoto C	J Oleo Sci
25975589	Screening Men with Coronary Heart Disease for Abdominal Aortic Aneurysm: A Prospective Cohort Study. (2015 Sep)	Vanni V	World J Surg
25789318	Association of polymorphisms of the receptor for advanced glycation end products gene and susceptibility to sporadic abdominal aortic aneurysm. (2015)	Yao Y	Biomed Res Int
27332825	Risk factors associated with increased prevalence of abdominal aortic aneurysm in women. (2016 Aug)	Chabok M	Br J Surg
19426607	Gender differences in abdominal aortic aneurysms. (2009 May-Jun)	Hannawa KK	Vascular
10826454	The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators. (2000 May 22)	Lederle FA	Arch Intern Med
15210603	Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. (2004 Jul 6)	Brady AR	Circulation
17903646	Abdominal aortic aneurysm in women: prevalence, risk factors, and implications for screening. (2007 Oct)	Derubertis BG	J Vasc Surg
29614976	Primary results of abdominal aortic aneurysm screening in the at-risk residents in middle China. (2018 Apr 3)	Li K	BMC Cardiovasc Disord
25172560	Treatment of abdominal aortic aneurysms: the role of endovascular repair. (2014 Sep)	Gordon PA	AORN J
19497516	Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association. (2009 Jun)	Elmore JR	J Vasc Surg
11565037	Abdominal aortic aneurysm repair. (2001 Sep-Oct)	Cruz CP	Vasc Surg
11683743	Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms. (2001 Nov)	Lindholt JS	Br J Surg
11668313	Plasma levels of plasmin-antiplasmin-complexes are predictive for small abdominal aortic aneurysms expanding to operation-recommendable sizes. (2001 Oct)	Lindholt JS	J Vasc Surg
24011812	Prevalence of abdominal aortic aneurysm is still high in certain areas of southern Europe. (2013 Nov)	Barba A	Ann Vasc Surg
24365123	Association of polymorphisms on chromosome 9p21.3 region with increased susceptibility of abdominal aortic aneurysm in a Chinese Han population. (2014 Apr)	Wei Y	J Vasc Surg
28527818	Predictors Associated With Increased Prevalence of Abdominal Aortic Aneurysm in Chinese Patients with Atherosclerotic Risk Factors. (2017 Jul)	Li W	Eur J Vasc Endovasc Surg
9501808	Epidemiology and potential for prevention of abdominal aortic aneurysm. (1998 Feb)	Wilmink AB	Br J Surg
12618703	Macrophage migration inhibitory factor is associated with aneurysmal expansion. (2003 Mar)	Pan JH	J Vasc Surg
29443371	Neutrophil Elastase-Derived Fibrin Degradation Products Indicate Presence of Abdominal Aortic Aneurysms and Correlate with Intraluminal Thrombus Volume. (2018 Feb)	Lindquist Liljeqvist M	Thromb Haemost
23506637	Mechanisms of oxidative stress in human aortic aneurysms--association with clinical risk factors for atherosclerosis and disease severity. (2013 Oct 3)	Guzik B	Int J Cardiol
28394003	The prevalence of abdominal aortic aneurysms in the rural/urban population in central Poland - Gniewkowo Aortic Study. (2017)	Derezinski TL	Kardiol Pol
26027897	Potential Interactions Between Genetic Polymorphisms of the Transforming Growth Factor-beta Pathway and Environmental Factors in Abdominal Aortic Aneurysms. (2015 Jul)	Zuo S	Eur J Vasc Endovasc Surg
14716800	Genetic approach to the role of cysteine proteases in the expansion of abdominal aortic aneurysms. (2004 Jan)	Eriksson P	Br J Surg
20622881	Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. (2010 Aug)	Gretarsdottir S	Nat Genet
29701381	Abdominal Aortic Aneurysm in Women: Retrospective Analysis of the Cases that Undergo Surgical Repair. (2017 Jul-Dec)	Pereira B	Rev Port Cir Cardiotorac Vasc
10361345	Vascular surgical society of great britain and ireland: non-steroidal anti-inflammatory drugs to treat abdominal aortic aneurysm (1999 May)	Franklin IJ	Br J Surg
17098543	Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation. (2006 Nov)	Xiong W	J Vasc Surg
29385469	Anti-TNF Therapeutic Drug Monitoring in Postoperative Crohn's Disease. (2018 May 25)	Wright EK	J Crohns Colitis
18055173	Renal response to open and endovascular repair of abdominal aortic aneurysm: a prospective study. (2008 Jan)	Gawenda M	Ann Vasc Surg
23958260	Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study. (2013 Sep)	Lv BJ	Atherosclerosis
26952864	A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences. (2016 May)	Thorgeirsson TE	Mol Psychiatry