Gene: NPL

80896
C112|C1orf13|NAL|NPL1
N-acetylneuraminate pyruvate lyase
protein-coding
1q25.3
Ensembl:ENSG00000135838 MIM:611412 Vega:OTTHUMG00000035321 UniprotKB:Q9BXD5
NG_053009.1
PubMed
0   ANCO-SNPs
OD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.610e-1 (AD)  9.093e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STK330.837
FERMT20.827
USP30.824
CPT20.823
WLS0.818
LEPROT0.812
RAB340.812
NPAS30.808
STON20.807
ERBB20.806

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGMAT-0.498
ABCC12-0.493
CALHM1-0.472
ADRA1D-0.468
GRIN3A-0.459
EPHA5-0.458
PPEF1-0.455
GABRG3-0.455
MCHR1-0.454
RTP1-0.453

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NPL mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NPL mRNA"25614096
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of NPL mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of NPL mRNA]"19414516
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NPL mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPL mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of NPL mRNA28959563
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of NPL mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPL gene27153756
D000447AldehydesAldehydes results in increased expression of NPL mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of NPL mRNA28522335
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of NPL mRNA"25351596
D001280AtrazineAtrazine results in increased expression of NPL mRNA25929836
D001280AtrazineAtrazine results in decreased expression of NPL mRNA22378314
C547126AZM551248AZM551248 results in increased expression of NPL mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of NPL mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPL mRNA23735875
D004958EstradiolEstradiol results in increased expression of NPL mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of NPL mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of NPL gene22576693
C006780bisphenol Abisphenol A affects the expression of NPL mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of NPL mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NPL mRNA25993096
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA]"20230807
D002330CarmustineNPL mRNA affects the susceptibility to Carmustine16365179
D016572CyclosporineCyclosporine results in decreased expression of NPL mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of NPL mRNA27989131
D003703DemecolcineDemecolcine results in increased expression of NPL mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NPL mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NPL mRNA27392435
D002945CisplatinCisplatin results in increased expression of NPL mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of NPL mRNA18042831|1845759
D004317DoxorubicinDoxorubicin affects the methylation of NPL gene28962528
D004726EndosulfanEndosulfan results in decreased expression of NPL mRNA28108160
C118739entinostatentinostat results in increased expression of NPL mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NPL mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of NPL mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of NPL mRNA22634610
D017313FenretinideFenretinide results in decreased expression of NPL mRNA28973697
D017313FenretinideFenretinide results in increased expression of NPL mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NPL mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NPL mRNA27392435
C544151jinfukangjinfukang results in increased expression of NPL mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NPL mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of NPL mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NPL mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA]"20230807
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of NPL mRNA24128854
C523799MRK 003NPL results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NPL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NPL mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of NPL mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of NPL mRNA16780908
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA]"20230807
D000073878Palm OilPalm Oil results in decreased expression of NPL mRNA18042831
D052638Particulate MatterParticulate Matter results in decreased expression of NPL mRNA24769257
C046012pentanalpentanal results in increased expression of NPL mRNA26079696
C006253pirinixic acidpirinixic acid results in decreased expression of NPL mRNA17426115
D011374ProgesteroneProgesterone affects the expression of NPL mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of NPL mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of NPL mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of NPL mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of NPL mRNA20436886
C016104sodium bichromatesodium bichromate results in decreased expression of NPL mRNA17685462
D012999SomanSoman results in increased expression of NPL mRNA19281266
C047246temozolomideNPL mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPL mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NPL mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NPL mRNA20133372
C012589trichostatin Atrichostatin A results in increased expression of NPL mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of NPL mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of NPL mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPL mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NPL mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NPL mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of NPL mRNA20546886
C025643vinclozolinvinclozolin results in increased expression of NPL mRNA23034163
D014750VincristineVincristine results in increased expression of NPL mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008747N-acetylneuraminate lyase activity-ISS-  
GO:0008747N-acetylneuraminate lyase activity-TAS-  
GO:0042802identical protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0019262N-acetylneuraminate catabolic process-IEA-  
GO:0019262N-acetylneuraminate catabolic process-TAS22692205  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17409192Genomewide suggestive linkage of opioid dependence to chromosome 14q. (2007 Jun 1)Lachman HMHum Mol Genet
16451637Whole-genome linkage analysis in mapping alcoholism genes using single-nucleotide polymorphisms and microsatellites. (2005 Dec 30)Wang SBMC Genet
18496835Ordered subsets linkage analysis of antisocial behavior in substance use disorder among participants in the Collaborative Study on the Genetics of Alcoholism. (2008 Oct 5)Jacobson KCAm J Med Genet B Neuropsychiatr Genet
10581489Linkage studies of D2 and D4 receptor genes and alcoholism. (1999 Dec 15)Hill SYAm J Med Genet
19959688Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. (2009 Dec)Hardin JCancer Epidemiol Biomarkers Prev