Gene: HMGA2

8091
BABL|HMGI-C|HMGIC|LIPO|STQTL9
high mobility group AT-hook 2
protein-coding
12q14.3
Ensembl:ENSG00000149948 MIM:600698 Vega:OTTHUMG00000168936 UniprotKB:P52926
NG_016296.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.269e-1 (AD)  6.416e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRTAP15-10.745
OR4C50.728
PRAMEF10.711
OR5AP20.705
ZNF705G0.703
OR5H150.701
OR51V10.701
UGT3A10.7
PCAT40.7
DSG40.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HYAL3-0.283
TMCC2-0.273
PVALB-0.273
FAM57B-0.263
RASL10B-0.258
DBP-0.255
GRIP2-0.254
TMEM221-0.254
NPPC-0.254
BCL11A-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of HMGA2 mRNA28329830
C0512461-methylanthraceneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HMGA2 mRNA]28329830
C0326681-nitropyrene1-nitropyrene results in increased expression of HMGA2 mRNA19041380
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of HMGA2 mRNA"20713471
C0127962-butenal2-butenal results in decreased expression of HMGA2 mRNA20471460
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of HMGA2 mRNA"25725129
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of HMGA2 protein"25725129
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of CDH2 protein]"25725129
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of VIM protein]"25725129
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased phosphorylation of STAT3 protein]"25725129
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in increased expression of CDH1 protein]"25725129
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"MIR33B mRNA affects the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of HMGA2 mRNA]"25725129
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HMGA2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGA2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of HMGA2 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGA2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HMGA2 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium results in increased expression of HMGA2 protein]27071802
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HMGA2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HMGA2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HMGA2 mRNA19770486
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of HMGA2 mRNA"22863853
D001151ArsenicArsenic affects the methylation of HMGA2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased sumoylation of HMGA2 protein18413806
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HMGA2 mRNA"18687144
D001374AzacitidineAzacitidine results in increased expression of HMGA2 mRNA21245298
D001374AzacitidineTP73 protein promotes the reaction [Azacitidine results in increased expression of HMGA2 mRNA]21245298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HMGA2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HMGA2 mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HMGA2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HMGA2 mRNA"20382639
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of HMGA2 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of HMGA2 mRNA25210133
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMGA2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HMGA2 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HMGA2 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of HMGA2 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of HMGA2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of HMGA2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HMGA2 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMGA2 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HMGA2 mRNA14729362
C018475butyraldehydebutyraldehyde results in increased expression of HMGA2 mRNA26079696
D002104CadmiumAcetylcysteine inhibits the reaction [Cadmium results in increased expression of HMGA2 protein]27071802
D002104CadmiumCadmium results in increased expression of HMGA2 mRNA27071802
D002104CadmiumCadmium results in increased expression of HMGA2 protein27071802
D002104CadmiumHMGA2 protein affects the reaction [Cadmium results in increased expression of CCNB1 protein]27071802
D002104CadmiumHMGA2 protein affects the reaction [Cadmium results in increased expression of CCND1 protein]27071802
D002104CadmiumHMGA2 protein affects the reaction [Cadmium results in increased expression of CCNE1 protein]27071802
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HMGA2 protein28830677
D019256Cadmium ChlorideHMGA2 protein affects the reaction [Cadmium Chloride results in increased expression of MMP2 protein]28830677
D019256Cadmium ChlorideHMGA2 protein affects the reaction [Cadmium Chloride results in increased expression of MMP9 protein]28830677
D019256Cadmium ChlorideHMGA2 protein affects the reaction [Cadmium Chloride results in increased phosphorylation of PTK2 protein]28830677
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HMGA2 protein28830677
C037123cadmium sulfatecadmium sulfate results in decreased expression of HMGA2 mRNA12064557
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HMGA2 mRNA27339419
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HMGA2 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HMGA2 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of HMGA2 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of HMGA2 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of HMGA2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HMGA2 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of HMGA2 mRNA19770486
D000069439DasatinibDasatinib results in decreased expression of HMGA2 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of HMGA2 mRNA23914054
D003703DemecolcineDemecolcine results in decreased expression of HMGA2 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMGA2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HMGA2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMGA2 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of HMGA2 mRNA19561079
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of HMGA2 mRNA21858171
D002945CisplatinCisplatin results in increased expression of HMGA2 mRNA21151649
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HMGA2 mRNA21527772
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HMGA2 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGA2 mRNA]17854601
D004221DisulfiramDisulfiram results in decreased expression of HMGA2 mRNA20530235
D004317DoxorubicinHMGA2 protein affects the susceptibility to Doxorubicin16217747
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HMGA2 mRNA23649840
D005047EtoposideHMGA2 protein affects the susceptibility to Etoposide16217747
D005411Flame RetardantsFlame Retardants results in increased expression of HMGA2 mRNA27219277
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of HMGA2 mRNA28329830
C007738fluorantheneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HMGA2 mRNA]28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HMGA2 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of HMGA2 mRNA23649840|2893796
D019833GenisteinGenistein results in decreased expression of HMGA2 mRNA22228119
D005839GentamicinsGentamicins results in decreased expression of HMGA2 mRNA22061828
D005947GlucoseGlucose results in increased expression of HMGA2 mRNA17178593
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HMGA2 mRNA24763279
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of HMGA2 mRNA27219277
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of HMGA2 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMGA2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HMGA2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMGA2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HMGA2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMGA2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HMGA2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HMGA2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of HMGA2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HMGA2 mRNA24796395|2530787
D007854LeadLead affects the expression of HMGA2 mRNA28903495
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of HMGA2 mRNA18386188
D008558MelphalanMelphalan results in decreased expression of HMGA2 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HMGA2 gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of HMGA2 mRNA22008535
D008748MethylcholanthreneMethylcholanthrene results in increased expression of HMGA2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HMGA2 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HMGA2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HMGA2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of HMGA2 mRNA24810058
D016685MitomycinHMGA2 protein affects the susceptibility to Mitomycin16217747
C028577monobutyl phthalatemonobutyl phthalate affects the expression of HMGA2 mRNA19162170
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of HMGA2 protein24625837
D010100OxygenOxygen deficiency results in decreased expression of HMGA2 mRNA26516004
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of HMGA2 mRNA18386188
C046012pentanalpentanal results in increased expression of HMGA2 mRNA26079696
D010634PhenobarbitalPhenobarbital results in increased expression of HMGA2 mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of HMGA2 mRNA19162173
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of HMGA2 mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in decreased expression of HMGA2 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HMGA2 mRNA19162173
D011374ProgesteroneNCOA2 protein affects the reaction [Progesterone results in decreased expression of HMGA2 mRNA]17556502
D011374ProgesteroneProgesterone results in decreased expression of HMGA2 mRNA17556502
D011374ProgesteroneProgesterone results in increased expression of HMGA217510236
C513428pyrachlostrobinpyrachlostrobin results in increased expression of HMGA2 mRNA27029645
C012526quercitrinquercitrin results in increased expression of HMGA2 mRNA25193878
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of HMGA2 mRNA14699072
C059514resveratrolresveratrol results in decreased expression of HMGA2 protein25505154
C093642SB 203580SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HMGA2 mRNA]28329830
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of HMGA2 mRNA"23917077
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HMGA2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of HMGA2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of HMGA2 mRNA19073995
C017947sodium arsenitesodium arsenite affects the methylation of HMGA2 gene28589171
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of HMGA2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HMGA2 mRNA19770486|2756255
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HMGA2 mRNA25613284
D013893ThiramThiram results in decreased expression of HMGA2 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of HMGA2 gene26756918
D019772TopotecanHMGA2 protein affects the susceptibility to Topotecan16217747
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of HMGA2 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of HMGA2 mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGA2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of HMGA2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HMGA2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of HMGA2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HMGA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HMGA2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HMGA2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of HMGA2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased expression of HMGA2 mRNA19136453|2054688
D014635Valproic AcidValproic Acid results in increased expression of HMGA2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HMGA2 gene25560391
D014750VincristineVincristine results in decreased expression of HMGA2 mRNA23649840
D015032ZincZinc deficiency results in increased expression of HMGA2 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA14627817  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000989transcription factor activity, transcription factor bindingcontributes_toIDA18832382  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18832382  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA14627817  
GO:0003677DNA binding-NAS8198613  
GO:0003680AT DNA binding-IDA14627817  17078040  17426251  20108983  21533145  
GO:0003680AT DNA binding-IMP18832382  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IBA21873635  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IDA19465398  
GO:0004677DNA-dependent protein kinase activity-IDA19549901  
GO:0005515protein binding-IPI16293633  17324944  19465398  
GO:0008134transcription factor binding-IPI14645522  
GO:0008301DNA binding, bending-IDA20108983  
GO:0008301DNA binding, bending-IMP14627817  
GO:0031492nucleosomal DNA binding-IDA17078040  
GO:0035497cAMP response element binding-IDA14645522  
GO:0035500MH2 domain binding-IDA18832382  
GO:0035501MH1 domain binding-IDA18832382  
GO:0044212transcription regulatory region DNA binding-IDA17426251  
GO:0046332SMAD binding-IPI18832382  
GO:00515755'-deoxyribose-5-phosphate lyase activity-IDA19465398  
GO:0070742C2H2 zinc finger domain binding-IMP14645522  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA14627817  
GO:0001837epithelial to mesenchymal transition-IMP18832382  
GO:0002062chondrocyte differentiation-IDA21484705  
GO:0003131mesodermal-endodermal cell signaling-IMP17624332  
GO:0006284base-excision repair-IBA21873635  
GO:0006284base-excision repair-IDA19465398  
GO:0006325chromatin organization-TAS19551524  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006355regulation of transcription, DNA-templated-IMP7606786  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007095mitotic G2 DNA damage checkpoint-IDA16061642  
GO:0007275multicellular organism development-TAS7606786  
GO:0009615response to virus-IEP17005673  
GO:0010564regulation of cell cycle process-IDA14645522  
GO:0010628positive regulation of gene expression-IDA18832382  
GO:0030261chromosome condensation-IEA-  
GO:0031052chromosome breakage-IDA19549901  
GO:0031507heterochromatin assembly-IDA16901784  
GO:0035978histone H2A-S139 phosphorylation-IDA16061642  
GO:0035986senescence-associated heterochromatin focus assembly-IDA16901784  
GO:0035987endodermal cell differentiation-IMP17624332  
GO:0035988chondrocyte proliferation-IDA21484705  
GO:0040008regulation of growth-IEA-  
GO:0042769DNA damage response, detection of DNA damage-IDA19465398  
GO:0043065positive regulation of apoptotic process-IDA16061642  
GO:0043066negative regulation of apoptotic process-IDA19465398  
GO:0043392negative regulation of DNA binding-IDA14645522  
GO:0043922negative regulation by host of viral transcription-IDA17005673  
GO:0045444fat cell differentiation-IMP7606786  17624332  
GO:0045766positive regulation of angiogenesis-ISS-  
GO:0045869negative regulation of single stranded viral RNA replication via double stranded DNA intermediate-IDA17005673  
GO:0045892negative regulation of transcription, DNA-templated-IDA18832382  
GO:0045892negative regulation of transcription, DNA-templated-IMP16901784  
GO:0045893positive regulation of transcription, DNA-templated-IDA15225648  15755872  17005673  17324944  17426251  
GO:0045893positive regulation of transcription, DNA-templated-IMP17624332  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14645522  18832382  
GO:0048333mesodermal cell differentiation-IMP17624332  
GO:0048762mesenchymal cell differentiation-IMP7606786  17624332  
GO:0048863stem cell differentiation-IEP17078040  
GO:0051301cell division-IEA-  
GO:0071158positive regulation of cell cycle arrest-IDA16061642  
GO:0071864positive regulation of cell proliferation in bone marrow-ISS-  
GO:0090402oncogene-induced cell senescence-IDA16901784  
GO:2000036regulation of stem cell population maintenance-IMP17624332  
GO:2000036regulation of stem cell population maintenance-TAS19551524  
GO:2000648positive regulation of stem cell proliferation-IDA21484705  
GO:2000648positive regulation of stem cell proliferation-IMP17624332  
GO:2000679positive regulation of transcription regulatory region DNA binding-IDA18832382  
GO:2000685positive regulation of cellular response to X-ray-IDA16061642  
GO:2000773negative regulation of cellular senescence-ISS-  
GO:2000774positive regulation of cellular senescence-IMP16901784  
GO:2001022positive regulation of response to DNA damage stimulus-IDA16061642  19465398  
GO:2001033negative regulation of double-strand break repair via nonhomologous end joining-IDA19549901  
GO:2001038regulation of cellular response to drug-IDA16061642  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-ISS-  
GO:0005634nucleus-HDA16791210  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16901784  17078040  17324944  
GO:0005654nucleoplasm-TAS-  
GO:0032993protein-DNA complex-IDA19465398  
GO:0035985senescence-associated heterochromatin focus-IDA16901784  
GO:0071141SMAD protein complex-IDA18832382  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559584Formation of Senescence-Associated Heterochromatin Foci (SAHF)TAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27421171Prognostic value of HMGA2, P16, and HPV in oral squamous cell carcinomas. (2016 Sep)Loeschke SJ Craniomaxillofac Surg
24121172Endobronchial lipomatous tumors: clinicopathologic analysis of 12 cases with molecular cytogenetic evidence supporting classification as "lipoma". (2013 Nov)Boland JMAm J Surg Pathol
23202124New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. (2013 Jan)Horikoshi MNat Genet