Gene: ACTN4

81
ACTININ-4|FSGS|FSGS1
actinin alpha 4
protein-coding
19q13.2
Ensembl:ENSG00000130402 MIM:604638 Vega:OTTHUMG00000137382 UniprotKB:O43707
NG_007082.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.520e-1 (AD)  9.903e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25383568chr19:39217721ACTN41.410e-10Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC370.904
U2AF20.904
NFE2L10.902
CIZ10.901
HGS0.898
PTPN230.897
AP3D10.897
UBA10.896
CTTN0.896
CSNK1E0.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.742
OR4F29-0.735
MTRNR2L6-0.266
KLRC2-0.242
MTRNR2L10-0.241
MTRNR2L9-0.228
ODAM-0.212
LRAT-0.207
HMHB1-0.207
KLRB1-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ACTN4 mRNA"20702594
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ACTN4 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ACTN4 mRNA"12376462
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of ACTN4 mRNA16460773
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ACTN4 mRNA"23196670
C0275764-hydroxy-2-nonenalACTN4 protein binds to 4-hydroxy-2-nonenal20043646
D000082AcetaminophenAcetaminophen affects the expression of ACTN4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACTN4 mRNA22100608
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ACTN4 protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACTN4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ACTN4 mRNA24449571
C044887beta-methylcholinebeta-methylcholine affects the expression of ACTN4 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ACTN4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ACTN4 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ACTN4 mRNA25181051
D001761BleomycinBleomycin results in decreased expression of ACTN4 protein25933445
C032036bromobenzenebromobenzene results in decreased expression of ACTN4 mRNA15056800
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of ACTN4 mRNA16460773
C515564bromovaninbromovanin results in increased expression of ACTN4 protein21419150
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of ACTN4 mRNA19395590
C043211carvedilolcarvedilol results in decreased expression of ACTN4 protein20403466
C100187chloropicrinchloropicrin results in increased expression of ACTN4 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACTN4 mRNA19320972
C030973cupric oxidecupric oxide results in increased expression of ACTN4 protein25470785
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of ACTN4 protein19822598
D016572CyclosporineCyclosporine results in decreased expression of ACTN4 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACTN4 mRNA17361019|2126653
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ACTN4 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of ACTN4 mRNA18042831
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ACTN4 mRNA"12376462
C024629dimethyl phthalatedimethyl phthalate affects the expression of ACTN4 mRNA26924002
D004317DoxorubicinDoxorubicin affects the localization of ACTN4 protein16636307
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ACTN4 protein23301498
D000431EthanolEthanol results in decreased expression of ACTN4 protein26185205
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN4 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of ACTN4 mRNA15954086
D018120FinasterideFinasteride results in increased expression of ACTN4 mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of ACTN4 mRNA18035473
C069837fullerene C60fullerene C60 results in decreased expression of ACTN4 mRNA19167457
C029424hydrazinehydrazine results in increased expression of ACTN4 mRNA15282401
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ACTN4 mRNA23430699
C410337K 7174K 7174 results in decreased expression of ACTN4 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ACTN4 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ACTN4 mRNA23103053
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ACTN4 protein19716841
D000073878Palm OilPalm Oil results in increased expression of ACTN4 mRNA18042831
C006253pirinixic acidpirinixic acid results in increased expression of ACTN4 mRNA23811191
C100573prostaglandin A1prostaglandin A1 analog results in increased metabolism of ACTN4 protein19800325
C012526quercitrinquercitrin affects the expression of ACTN4 mRNA25193878
C059514resveratrolresveratrol results in decreased expression of ACTN4 protein25505154
D012643SeleniumSelenium results in increased expression of ACTN4 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of ACTN4 protein25895662
D019821SimvastatinSimvastatin results in increased expression of ACTN4 mRNA16710349
D013311StreptozocinStreptozocin results in increased expression of ACTN4 protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein]19634143
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACTN4 mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTN4 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACTN4 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACTN4 mRNA28111298
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein]19634143
D014635Valproic AcidValproic Acid results in decreased expression of ACTN4 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ACTN4 mRNA17292431
C025643vinclozolinvinclozolin results in increased expression of ACTN4 mRNA22570695
D014810Vitamin EVitamin E results in increased expression of ACTN4 mRNA19244175
C088658zoledronic acidzoledronic acid results in decreased expression of ACTN4 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA25411248  
GO:0001882nucleoside binding-IDA12411747  
GO:0003723RNA binding-HDA22658674  
GO:0003779actin binding-TAS8104223  
GO:0005178integrin binding-TAS8104223  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI15619032  15841212  15988023  16189514  16204054  16944923  
19447967  22351778  22662192  24802111  25241761  25411248  
25416956  25910212  26496610  26871637  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IMP22351778  
GO:0031490chromatin DNA binding-IDA25411248  
GO:0035257nuclear hormone receptor binding-IPI22351778  
GO:0042803protein homodimerization activity-IPI22351778  
GO:0042803protein homodimerization activity-TAS15841212  
GO:0042974retinoic acid receptor binding-IPI22351778  
GO:0044325ion channel binding-IPI19943616  
GO:0047485protein N-terminus binding-IEA-  
GO:0051015actin filament binding-IDA12411747  
GO:0051015actin filament binding-IMP25918384  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0002576platelet degranulation-TAS-  
GO:0015031protein transport-IEA-  
GO:0030050vesicle transport along actin filament-IMP25918384  
GO:0030335positive regulation of cell migration-IMP25918384  
GO:0032417positive regulation of sodium:proton antiporter activity-NAS11948184  
GO:0035357peroxisome proliferator activated receptor signaling pathway-IDA22351778  
GO:0042981regulation of apoptotic process-NAS16807302  
GO:0048384retinoic acid receptor signaling pathway-IDA22351778  
GO:0048549positive regulation of pinocytosis-IEA-  
GO:0051017actin filament bundle assembly-IEA-  
GO:0051271negative regulation of cellular component movement-IEA-  
GO:0051272positive regulation of cellular component movement-IDA9508771  
GO:0051272positive regulation of cellular component movement-IMP15048094  
GO:0070830bicellular tight junction assembly-IEA-  
GO:1900025negative regulation of substrate adhesion-dependent cell spreading-IMP25918384  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IMP25411248  
GO:1902396protein localization to bicellular tight junction-IEA-  
GO:1903506regulation of nucleic acid-templated transcription-IMP22351778  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IEA-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005622intracellular-IDA21784188  
GO:0005634nucleus-IDA9508771  22351778  25411248  
GO:0005737cytoplasm-HDA16791210  
GO:0005737cytoplasm-IDA9508771  22351778  25411248  
GO:0005829cytosol-IDA-  
GO:0005903brush border-IEA-  
GO:0005911cell-cell junction-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeletoncolocalizes_withIDA25918384  
GO:0016604nuclear body-IDA-  
GO:0030018Z disc-IEA-  
GO:0030863cortical cytoskeleton-IEA-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0031143pseudopodium-TAS1629252  
GO:0032991protein-containing complex-IDA11948184  
GO:0043005neuron projection-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA15619032  
GO:0070062extracellular exosome-HDA19199708  20458337  21362503  23533145  
GO:1990904ribonucleoprotein complex-IDA17289661  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05146Amoebiasis
hsa05322Systemic lupus erythematosus
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-373753Nephrin family interactionsIEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28111298Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke. (2017 Mar)Szostak JFood Chem Toxicol