Gene: IFT88

8100
D13S1056E|DAF19|TG737|TTC10|hTg737
intraflagellar transport 88
protein-coding
13q12.11
Ensembl:ENSG00000032742 MIM:600595 Vega:OTTHUMG00000016517 UniprotKB:Q13099
NC_000013.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.252e-1 (AD)  3.319e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9506528chr13:20614200 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG160.828
STXBP30.82
FNTA0.818
NUDCD20.805
AIMP10.802
RDX0.795
GINM10.791
KCTD30.788
OSBPL90.784
PRTFDC10.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.445
OR4F5-0.417
CHRNA2-0.353
SHISA8-0.324
ELFN1-0.318
EPPIN-0.311
OPRD1-0.309
GRIN2D-0.308
BEAN1-0.274
TWIST2-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of IFT88 mRNA"20638727
D000082AcetaminophenAcetaminophen results in decreased expression of IFT88 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of IFT88 mRNA17585979
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of IFT88 mRNA21298039
D001151ArsenicArsenic affects the methylation of IFT88 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of IFT88 mRNA"25351596
D001280AtrazineAtrazine results in decreased expression of IFT88 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IFT88 mRNA20106945
D004958EstradiolEstradiol results in decreased expression of IFT88 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of IFT88 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of IFT88 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of IFT88 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of IFT88 mRNA25181051
D002118CalciumGadolinium inhibits the reaction [IFT88 protein mutant form results in increased uptake of Calcium]16396941
D002118CalciumIFT88 protein affects the reaction [PKD2 protein results in increased uptake of Calcium]16396941
D002118CalciumIFT88 protein mutant form results in increased uptake of Calcium16396941
D002994ClofibrateClofibrate results in decreased expression of IFT88 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of IFT88 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of IFT88 mRNA27989131
C000944dicrotophosdicrotophos results in decreased expression of IFT88 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of IFT88 mRNA26924002
D004052DiethylnitrosamineIFT88 gene mutant form results in increased susceptibility to Diethylnitrosamine9362446
C024629dimethyl phthalatedimethyl phthalate affects the expression of IFT88 mRNA26924002
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IFT88 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IFT88 mRNA17555576
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of IFT88 gene15755804|1672432
C039281furanfuran results in increased methylation of IFT88 gene22079235
D005682GadoliniumGadolinium inhibits the reaction [IFT88 protein mutant form results in increased uptake of Calcium]16396941
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of IFT88 gene28505145
D017313FenretinideFenretinide results in increased expression of IFT88 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT88 protein18951874
C410337K 7174K 7174 results in increased expression of IFT88 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IFT88 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IFT88 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of IFT88 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IFT88 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of IFT88 mRNA26924002
C568376MT19c compoundMT19c compound results in increased expression of IFT88 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IFT88 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IFT88 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of IFT88 mRNA22714537
D010795Phthalic AcidsPhthalic Acids results in decreased expression of IFT88 mRNA21061450
D010936Plant ExtractsPlant Extracts results in increased expression of IFT88 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IFT88 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IFT88 mRNA22079256
C045362prochlorazprochloraz results in increased expression of IFT88 mRNA21470553
D013629TamoxifenTamoxifen affects the expression of IFT88 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IFT88 mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT88 protein18951874
D014212TretinoinTretinoin results in increased expression of IFT88 mRNA23724009
D014520UrethaneUrethane results in decreased expression of IFT88 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of IFT88 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of IFT88 mRNA23179753|2915479

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25564561  27173435  
GO:0019894kinesin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-IBA21873635  
GO:0035735intraciliary transport involved in cilium assembly-TAS-  
GO:0060122inner ear receptor cell stereocilium organization-IBA21873635  
GO:0060271cilium assembly-ISS-  
GO:1902017regulation of cilium assembly-ISS-  
GO:1905515non-motile cilium assembly-IBA21873635  
GO:2000785regulation of autophagosome assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005814centriole-IBA21873635  
GO:0005814centriole-IDA27623382  
GO:0005814centriole-ISS-  
GO:0005929cilium-IDA24421332  28428259  
GO:0005929cilium-ISS-  
GO:0005929cilium-TAS-  
GO:0030992intraciliary transport particle B-ISS-  
GO:0031514motile cilium-ISS-  
GO:0036064ciliary basal body-IBA21873635  
GO:0036064ciliary basal body-IDA28428259  28625565  
GO:0036064ciliary basal body-ISS-  
GO:0097542ciliary tip-TAS-  
GO:0097546ciliary base-IBA21873635  
GO:0097730non-motile cilium-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5617833Cilium AssemblyIEA
R-HSA-5620924Intraflagellar transportTAS
R-HSA-5620924Intraflagellar transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal