Gene: SLC25A32

81034
MFT|MFTC|RREI
solute carrier family 25 member 32
protein-coding
8q22.3
Ensembl:ENSG00000164933 MIM:610815 Vega:OTTHUMG00000164790 UniprotKB:Q9H2D1
NG_047200.1
PubMed
0   ANCO-SNPs
ND
1   
9.625e-1 (AD)  7.756e-1 (ND)   (Frontal_Cortex)
2.903e-1 (AD)  6.486e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTMR60.947
TMX30.947
CDC270.945
DNAJB140.941
SLC25A460.941
BBS70.939
BTF3L40.938
C5orf220.936
ARMC80.936
CCNC0.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.495
OR4F29-0.453
FXYD3-0.397
CSAG1-0.396
MTRNR2L10-0.381
EYA2-0.381
MTRNR2L9-0.377
RHOD-0.376
MTRNR2L6-0.367
ACOX2-0.361

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00158Folic AcidSmall Molecule59-30-3Approved|NutraceuticalTransporter
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC25A32 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC25A32 mRNA]"19467301
C0303715,6,7,8-tetrahydrofolic acid"SLC25A32 protein binds to and affects the transport of 5,6,7,8-tetrahydrofolic acid"21768094
D000082AcetaminophenAcetaminophen results in decreased expression of SLC25A32 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of SLC25A32 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SLC25A32 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC25A32 gene27153756
D000452AldrinAldrin results in decreased expression of SLC25A32 mRNA18579281
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC25A32 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of SLC25A32 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of SLC25A32 mRNA25181051
D002104CadmiumCadmium results in decreased expression of SLC25A32 mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC25A32 mRNA26472689
D002922CiguatoxinsCiguatoxins affects the expression of SLC25A32 mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC25A32 mRNA18579281
D016572CyclosporineCyclosporine results in increased expression of SLC25A32 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of SLC25A32 mRNA25047013
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLC25A32 mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC25A32 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SLC25A32 mRNA19467301
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SLC25A32 mRNA20064776
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SLC25A32 mRNA23649840
D005492Folic AcidSLC25A32 gene mutant form results in decreased transport of Folic Acid17279620
C039281furanfuran results in increased expression of SLC25A32 mRNA26194646
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC25A32 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLC25A32 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SLC25A32 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLC25A32 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLC25A32 mRNA"29244179
D010634PhenobarbitalPhenobarbital affects the expression of SLC25A32 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of SLC25A32 mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of SLC25A32 mRNA23557933
C009250sevofluranesevoflurane affects the expression of SLC25A32 mRNA15967596
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC25A32 mRNA"18579281
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A32 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A32 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SLC25A32 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC25A32 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A32 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC25A32 mRNA21724226
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC25A32 mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of SLC25A32 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of SLC25A32 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC25A32 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC25A32 mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in increased expression of SLC25A32 mRNA15901671
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA]19225232
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC25A32 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SLC25A32 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of SLC25A32 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008517folic acid transmembrane transporter activity-IBA21873635  
GO:0008517folic acid transmembrane transporter activity-ISS-  
GO:0008517folic acid transmembrane transporter activity-NAS10978331  
GO:0008517folic acid transmembrane transporter activity-TAS-  
GO:0015230FAD transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006544glycine metabolic process-IGI15140890  
GO:0006544glycine metabolic process-ISS-  
GO:0015884folic acid transport-NAS10978331  
GO:0035350FAD transmembrane transport-IEA-  
GO:0046655folic acid metabolic process-TAS-  
GO:1904947folate import into mitochondrion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA21956163  
GO:0005743mitochondrial inner membrane-NAS10978331  
GO:0005743mitochondrial inner membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22649255Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)Wernimont SMJ Nutr