Gene: CLPTM1L

81037
CRR9
CLPTM1 like
protein-coding
5p15.33
Ensembl:ENSG00000049656 MIM:612585 Vega:OTTHUMG00000131015 UniprotKB:Q96KA5
NG_046903.1
PubMed
0   ANCO-SNPs
ND
15   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.404e-1 (AD)  9.756e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCT70.958
PSMD80.957
MTCH10.957
ATP6V0B0.954
ARPC1A0.953
STOML20.951
TIMM500.95
WIPI20.95
WRNIP10.948
RNF100.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.755
OR4F29-0.707
IL18RAP-0.322
VNN3-0.294
P2RY14-0.293
MTRNR2L6-0.291
KLRB1-0.29
ASB4-0.288
CXCR2-0.286
VNN2-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CLPTM1L mRNA"26377693
D000082AcetaminophenAcetaminophen affects the expression of CLPTM1L mRNA17562736
D000638AmiodaroneAmiodarone affects the expression of CLPTM1L mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CLPTM1L mRNA24449571
D001151ArsenicArsenic affects the methylation of CLPTM1L gene25304211
C015001arsenitearsenite results in increased methylation of CLPTM1L promoter23974009
D001553BenzbromaroneBenzbromarone affects the expression of CLPTM1L mRNA19483382
C006780bisphenol Abisphenol A affects the expression of CLPTM1L mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CLPTM1L mRNA25181051
D002166CamptothecinCLPTM1L mutant form results in increased susceptibility to Camptothecin22675468
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CLPTM1L mRNA27339419
D002994ClofibrateClofibrate affects the expression of CLPTM1L mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of CLPTM1L mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of CLPTM1L mRNA19789285
D002945CisplatinBCL2L1 protein inhibits the reaction [CLPTM1L mutant form results in increased susceptibility to Cisplatin]22675468
D002945CisplatinCLPTM1L mutant form results in increased susceptibility to Cisplatin22675468
D002945Cisplatin[CLPTM1L mutant form results in increased susceptibility to Cisplatin] which results in decreased expression of BCL2L1 protein22675468
D002945Cisplatin[CLPTM1L mutant form results in decreased expression of BCL2L1 protein] which results in increased susceptibility to Cisplatin24366883
D002945CisplatinCLPTM1L mutant form results in increased susceptibility to Cisplatin24366883
D005001EthionineEthionine affects the expression of CLPTM1L mRNA19483382
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CLPTM1L mRNA20044591
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CLPTM1L mRNA24810058
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of CLPTM1L mRNA24128854
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLPTM1L mRNA"25554681
D009853OmeprazoleOmeprazole affects the expression of CLPTM1L mRNA19483382
C006253pirinixic acidpirinixic acid affects the expression of CLPTM1L mRNA19483382
C045950propiconazolepropiconazole results in increased expression of CLPTM1L mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of CLPTM1L mRNA19483382
D013853ThioacetamideThioacetamide affects the expression of CLPTM1L mRNA19483382
D014241TrichloroethyleneTrichloroethylene results in increased expression of CLPTM1L mRNA19448997
D014635Valproic AcidValproic Acid affects the expression of CLPTM1L mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CLPTM1L mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of CLPTM1L gene29154799
C025643vinclozolinvinclozolin results in decreased expression of CLPTM1L mRNA23034163
D015032ZincZinc deficiency results in increased expression of CLPTM1L mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25422207Genetic variant in CLPTM1L confers reduced risk of lung cancer: a replication study in Chinese and a meta-analysis. (2014)Luo XAsian Pac J Cancer Prev
28789383Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males. (2017 Aug)Xiao XOncol Lett
25526467CLPTM1L genetic polymorphisms and interaction with smoking and alcohol drinking in lung cancer risk: a case-control study in the Han population from northwest China. (2014 Dec)Xun XMedicine (Baltimore)
24163739Genetic susceptibility to lung cancer and co-morbidities. (2013 Oct)Yang IAJ Thorac Dis
19955392Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. (2010 Feb)Wang YCarcinogenesis
25924736Lower lung cancer rates in Jewish smokers in Israel and the USA. (2015 Nov 1)Rennert GInt J Cancer
25037574Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case-control study in a Chinese non-smoking female population. (2014 Aug)Yin ZMed Oncol
24175795No association of XRCC1 and CLPTM1L polymorphisms with non-small cell lung cancer in a non-smoking Han Chinese population. (2013)Sun YAsian Pac J Cancer Prev
21622582The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema. (2011 Oct)Wauters EEur Respir J
23300716CLPTM1L is overexpressed in lung cancer and associated with apoptosis. (2012)Ni ZPLoS One
23555636Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. (2013)Lan QPLoS One
25233467Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. (2014)Tseng TSPLoS One
20700438The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. (2010 Aug 5)Hsiung CAPLoS Genet
24679952A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC). (2014 Jun)Azad AKLung Cancer
23908149Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population. (2013 Nov)Zhong RMol Carcinog