Gene: TCL1A

8115
TCL1
T cell leukemia/lymphoma 1A
protein-coding
14q32.13
Ensembl:ENSG00000100721 MIM:186960 Vega:OTTHUMG00000171390 UniprotKB:P56279
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.584e-1 (AD)  5.774e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MS4A10.563
SSX20.39
P2RY100.372
CD79A0.35
KLRB10.334
GRAPL0.334
BLK0.32
KLK120.315
SLC28A20.314
OR52H10.312

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC39A14-0.295
ING1-0.295
BRF2-0.293
PDSS2-0.293
CILP2-0.293
AIMP2-0.283
GGH-0.281
ARG2-0.281
CCT5-0.275
HSPA4L-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of TCL1A mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TCL1A mRNA21298039
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of TCL1A gene28505145
C006780bisphenol Abisphenol A results in decreased expression of TCL1A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TCL1A gene28505145
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of TCL1A gene28505145
C017947sodium arsenitesodium arsenite results in increased expression of TCL1A mRNA25879800

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  16934922  19064921  21516116  25416956  25910212  
26871637  27107012  27107014  
GO:0019901protein kinase binding-IPI10983986  
GO:0042802identical protein binding-IDA10983986  
GO:0042802identical protein binding-IPI25416956  
GO:0043539protein serine/threonine kinase activator activity-IMP10983986  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-TAS7809072  
GO:0008284positive regulation of cell proliferation-IDA10983986  
GO:0010918positive regulation of mitochondrial membrane potential-IDA10983986  
GO:0032461positive regulation of protein oligomerization-IDA10983986  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IMP10983986  
GO:0043066negative regulation of apoptotic process-IDA10983986  
GO:0070207protein homotrimerization-IDA10983986  
GO:0071356cellular response to tumor necrosis factor-IDA10983986  
GO:0071902positive regulation of protein serine/threonine kinase activity-IDA10983986  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0032991protein-containing complex-IMP10983986  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27064253Mosaic loss of chromosome Y is associated with common variation near TCL1A. (2016 May)Zhou WNat Genet