Gene: ST8SIA2

8128
HsT19690|SIAT8-B|SIAT8B|ST8SIA-II|ST8SiaII|STX
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
protein-coding
15q26.1
Ensembl:ENSG00000140557 MIM:602546 Vega:OTTHUMG00000149843 UniprotKB:Q92186
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.878e-1 (AD)  6.198e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH0.726
C8orf340.722
MARCH40.687
TRIM670.676
GALNTL60.663
PTHLH0.662
IGF10.659
VWC20.656
SST0.655
MSANTD10.65

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOS-0.499
NFE2-0.486
CDA-0.476
PRKX-0.466
HVCN1-0.466
ROM1-0.454
HEBP2-0.45
CP-0.441
RARRES3-0.437
RGL3-0.435

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST8SIA2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST8SIA2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST8SIA2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST8SIA2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST8SIA2 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ST8SIA2 mRNA25064622
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA2 mRNA]21233418
D000638AmiodaroneAmiodarone affects the expression of ST8SIA2 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ST8SIA2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ST8SIA2 mRNA24449571
C015001arsenitearsenite results in increased methylation of ST8SIA2 promoter23974009
D001374AzacitidineAzacitidine results in decreased expression of ST8SIA2 mRNA20823114
C044887beta-methylcholinebeta-methylcholine affects the expression of ST8SIA2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of ST8SIA2 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of ST8SIA2 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of ST8SIA2 mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ST8SIA2 gene20938992
D016572CyclosporineCyclosporine affects the expression of ST8SIA2 mRNA25064622
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ST8SIA2 mRNA17361019|2126653
D004041Dietary FatsDietary Fats results in increased expression of ST8SIA2 mRNA25016146
D004147DioxinsDioxins affects the expression of ST8SIA2 mRNA20463971
C118739entinostatentinostat results in decreased expression of ST8SIA2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA2 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of ST8SIA2 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ST8SIA2 mRNA25064622
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ST8SIA2 gene20938992
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ST8SIA2 mRNA22634610
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ST8SIA2 mRNA17183730
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of ST8SIA2 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ST8SIA2 mRNA]26733615
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ST8SIA2 mRNA]26733615
D007854LeadLead affects the splicing of ST8SIA2 mRNA28903495
C029891lead chloridelead chloride results in decreased expression of ST8SIA2 mRNA18499259
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ST8SIA2 gene20938992
D008727MethotrexateMethotrexate results in increased expression of ST8SIA2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ST8SIA2 mRNA28001369
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ST8SIA2 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of ST8SIA2 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ST8SIA2 mRNA]26733615
D010269ParaquatParaquat affects the expression of ST8SIA2 mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ST8SIA2 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ST8SIA2 mRNA26272509
D011748PyrogallolPyrogallol results in decreased expression of ST8SIA2 mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in decreased expression of ST8SIA2 mRNA]20362636
D012834SilverSilver results in increased expression of ST8SIA2 mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in decreased expression of ST8SIA2 mRNA]20362636
C017947sodium arsenitesodium arsenite affects the methylation of ST8SIA2 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of ST8SIA2 mRNA23811142
D013752TetracyclineTetracycline affects the expression of ST8SIA2 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of ST8SIA2 mRNA25064622
C012589trichostatin Atrichostatin A results in decreased expression of ST8SIA2 mRNA24935251
D014415TunicamycinTunicamycin results in decreased expression of ST8SIA2 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of ST8SIA2 mRNA25064622
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ST8SIA2 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST8SIA2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ST8SIA2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of ST8SIA2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ST8SIA2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity-IDA10766765  
GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity-TAS-  
GO:0033691sialic acid binding-IC10766765  
GO ID GO Term Qualifier Evidence PubMed
GO:0001574ganglioside biosynthetic process-IDA10766765  
GO:0005975carbohydrate metabolic process-TAS7559389  
GO:0006464cellular protein modification process-TAS7559389  
GO:0006486protein glycosylation-IDA10766765  
GO:0006486protein glycosylation-IEA-  
GO:0006491N-glycan processing-IDA10766765  
GO:0007399nervous system development-TAS9054414  
GO:0009311oligosaccharide metabolic process-IDA10766765  
GO:0097503sialylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005769early endosome-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0055037recycling endosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-419037NCAM1 interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975577N-Glycan antennae elongationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29577422NOTCH4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case-control study. (2018 Mar 26)Shi XJ Clin Lab Anal