Gene: CALU

813
-
calumenin
protein-coding
7q32.1
Ensembl:ENSG00000128595 MIM:603420 Vega:OTTHUMG00000158274 UniprotKB:O43852
NG_033110.1
PubMed
0   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.827e-1 (AD)  9.234e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX210.864
TXNDC50.857
COPB20.844
SEC23B0.84
XRN20.839
ARFGAP30.833
CEBPZ0.828
PTPN10.826
ADAM90.825
SYNCRIP0.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.587
OR4F5-0.581
GRIFIN-0.174
FEV-0.171
LCN1-0.171
BRDT-0.165
NKX6-3-0.165
KRTAP5-8-0.154
CRYBA2-0.148
LYPD8-0.146

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of CALU mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CALU mRNA"23146750
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CALU mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CALU mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of CALU mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CALU mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of CALU mRNA11793227
D000082AcetaminophenAcetaminophen affects the expression of CALU mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of CALU mRNA17522070
D020106AcrylamideAcrylamide affects the expression of CALU mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CALU mRNA16483693
D001280AtrazineAtrazine results in increased expression of CALU mRNA22378314
C406592azaspiracidazaspiracid results in increased expression of CALU mRNA28939011
C547126AZM551248AZM551248 results in increased expression of CALU mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CALU mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CALU mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of CALU mRNA25181051
D001761BleomycinBleomycin results in increased expression of CALU protein25933445
C021636bromadiolonebromadiolone results in increased expression of CALU mRNA17994578
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CALU mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of CALU mRNA26191083
D002101Cacodylic AcidCacodylic Acid results in increased expression of CALU mRNA16122865
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CALU mRNA25993096
D002110CaffeineCaffeine results in decreased expression of CALU mRNA11793227
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CALU mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CALU mRNA17522070
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CALU mRNA23650126
D002725ChloroformChloroform results in increased expression of CALU mRNA17522070
C100187chloropicrinchloropicrin results in decreased expression of CALU mRNA26352163
C018021cobaltous chloridecobaltous chloride results in decreased expression of CALU mRNA19376846
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CALU mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of CALU mRNA19167446
C030973cupric oxidecupric oxide results in increased expression of CALU protein25470785
D016572CyclosporineCyclosporine results in decreased expression of CALU mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CALU mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased methylation of CALU promoter27989131
D003907DexamethasoneDexamethasone results in increased expression of CALU mRNA17522070
D004229DithiothreitolDithiothreitol results in increased expression of CALU protein21692457
D004298DopamineDopamine results in increased expression of CALU mRNA21983523
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CALU protein23301498
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of CALU mRNA17522070
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CALU mRNA23649840
D018818FenoldopamFenoldopam results in increased expression of CALU mRNA21983523
D005557FormaldehydeFormaldehyde results in decreased expression of CALU mRNA23649840
D005897GlafenineGlafenine results in increased expression of CALU mRNA24136188
D005947GlucoseGlucose deficiency results in decreased secretion of CALU protein24802182
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CALU protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of CALU protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CALU mRNA20044591
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CALU protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CALU protein23178681
C410337K 7174K 7174 results in increased expression of CALU mRNA24086573
C008261lead acetatelead acetate results in increased expression of CALU mRNA20542052
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CALU mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of CALU protein26558463
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CALU mRNA19010555
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CALU mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CALU protein"22001959
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CALU mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CALU mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CALU mRNA17522070
D009532NickelNickel results in increased expression of CALU mRNA24768652|2558310
C017557nickel subsulfidenickel subsulfide results in increased expression of CALU mRNA21086188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CALU protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CALU protein28126411
D010476PerfumePerfume results in increased expression of CALU mRNA24768652
D019800PhenolPhenol results in decreased expression of CALU mRNA17547211
D010936Plant ExtractsPlant Extracts results in increased expression of CALU mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CALU mRNA23608068
C059514resveratrolresveratrol affects the secretion of CALU protein24802182
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of CALU mRNA19244175
D012643SeleniumSelenium results in increased expression of CALU mRNA19244175
D012834SilverSilver results in decreased expression of CALU mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of CALU protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CALU mRNA21570461|2468072
D013752TetracyclineTetracycline results in increased expression of CALU mRNA17522070
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of CALU protein20109541
D019284ThapsigarginThapsigargin results in decreased expression of CALU mRNA21692457
D019284ThapsigarginThapsigargin results in decreased expression of CALU protein21692457
D019284ThapsigarginThapsigargin results in increased expression of CALU mRNA22378314
D013806TheophyllineTheophylline results in increased expression of CALU mRNA17522070
D013853ThioacetamideThioacetamide results in decreased expression of CALU mRNA11793227
C012589trichostatin Atrichostatin A results in increased expression of CALU mRNA24935251
D014415TunicamycinTunicamycin results in increased expression of CALU mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CALU mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CALU mRNA28001369
D014750VincristineVincristine results in increased expression of CALU mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of CALU mRNA19244175
D014810Vitamin EVitamin E results in increased expression of CALU mRNA19244175
D014859WarfarinCALU gene SNP affects the susceptibility to Warfarin27632229
D014859WarfarinCALU polymorphism affects the susceptibility to Warfarin20200517
D014859WarfarinCALU protein results in decreased susceptibility to Warfarin11641264
D015016YohimbineYohimbine results in increased expression of CALU mRNA21983523

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IDA10094503  
GO:0005515protein binding-IPI18688696  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0016020membrane-HDA19946888  
GO:0033018sarcoplasmic reticulum lumen-IEA-  
GO:0042470melanosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-114608Platelet degranulation IEA
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-76005Response to elevated platelet cytosolic Ca2+IEA
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21110013Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. (2011 Apr)Geisen CEur J Clin Pharmacol
28049362Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients. (2018 Mar)Gaikwad TClin Appl Thromb Hemost
25769181Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells. (2015 Mar)Wang BYMutat Res
15714438Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines. (2005 Jul)Weng MWEnviron Mol Mutagen
21228733Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients. (2011 Mar)Shahin MHPharmacogenet Genomics
25402559IGF2R expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. (2014)Tian ZCell Physiol Biochem
29615835The effect of electronic cigarette and tobacco smoke exposure on COPD bronchial epithelial cell inflammatory responses. (2018)Higham AInt J Chron Obstruct Pulmon Dis
24106801Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis. (2014 Mar)Lambert JAAm J Respir Cell Mol Biol