Gene: NPRL3

8131
C16orf35|CGTHBA|FFEVF3|HS-40|MARE|NPR3|RMD11
NPR3 like, GATOR1 complex subunit
protein-coding
16p13.3
Ensembl:ENSG00000103148 MIM:600928 Vega:OTTHUMG00000047792 UniprotKB:Q12980
NG_029669.1
PubMed
0   ANCO-SNPs
ND
0   
6.364e-1 (AD)  8.599e-1 (ND)   (Frontal_Cortex)
8.553e-1 (AD)  7.978e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBC1D170.899
MTA10.867
RAB11B0.865
PTPN230.864
TBC1D130.864
DTX30.86
GNAO10.858
SCAP0.857
UBE2L30.857
GGA10.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.75
OR4F29-0.715
TFPI2-0.3
SUCNR1-0.289
CLEC6A-0.289
GSDMA-0.279
CEACAM3-0.265
KCNJ15-0.265
C2orf83-0.262
CEACAM20-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPRL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPRL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPRL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPRL3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NPRL3 mRNA25064622
D000638AmiodaroneAmiodarone affects the expression of NPRL3 mRNA25064622
D001151ArsenicArsenic affects the methylation of NPRL3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPRL3 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of NPRL3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NPRL3 gene28505145
D002104CadmiumCadmium results in increased expression of NPRL3 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of NPRL3 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of NPRL3 mRNA25979313
D002746ChlorpromazineChlorpromazine affects the expression of NPRL3 mRNA25064622
C018021cobaltous chloridecobaltous chloride results in decreased expression of NPRL3 mRNA19320972
D003042CocaineCocaine affects the expression of NPRL3 mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of NPRL3 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of NPRL3 mRNA25064622
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NPRL3 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of NPRL3 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NPRL3 mRNA25064622
C492448ICG 001ICG 001 results in increased expression of NPRL3 mRNA26191083
D007657Ketone BodiesKetone Bodies results in decreased expression of NPRL3 mRNA16807920
C042720mercuric bromidemercuric bromide results in decreased expression of NPRL3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPRL3 mRNA"27188386
D009532NickelNickel results in decreased expression of NPRL3 mRNA25583101
D010269ParaquatParaquat affects the expression of NPRL3 mRNA25064622
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPRL3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NPRL3 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of NPRL3 mRNA21061450
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NPRL3 mRNA25351596
D012999SomanSoman results in decreased expression of NPRL3 mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of NPRL3 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPRL3 mRNA21570461
D013752TetracyclineTetracycline affects the expression of NPRL3 mRNA25064622
D013849ThimerosalThimerosal results in decreased expression of NPRL3 mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of NPRL3 mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NPRL3 mRNA25447457|2806579
D014635Valproic AcidValproic Acid affects the expression of NPRL3 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of NPRL3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NPRL3 mRNA28001369
C025643vinclozolinvinclozolin results in decreased expression of NPRL3 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of NPRL3 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of NPRL3 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activitycontributes_toIDA23723238  
GO ID GO Term Qualifier Evidence PubMed
GO:0003281ventricular septum development-IEA-  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0032007negative regulation of TOR signaling-IMP23723238  
GO:0034198cellular response to amino acid starvation-IBA21873635  
GO:0034198cellular response to amino acid starvation-IMP23723238  
GO:0035909aorta morphogenesis-IEA-  
GO:0038202TORC1 signaling-IBA21873635  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0048738cardiac muscle tissue development-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:2000785regulation of autophagosome assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-IDA28199306  
GO:0005773vacuole-IBA21873635  
GO:1990130GATOR1 complex-IBA21873635  
GO:1990130GATOR1 complex-IDA23723238  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal