Gene: GAN

8139
GAN1|KLHL16
gigaxonin
protein-coding
16q23.2
Ensembl:ENSG00000261609 MIM:605379 Vega:OTTHUMG00000137627 UniprotKB:Q9H2C0
NG_009007.1
PubMed
0   ANCO-SNPs
CD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.968e-1 (AD)  5.260e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACOX10.825
TPP10.787
NEO10.783
MTA20.783
GPR75-ASB30.782
LPIN10.777
ZNF2750.773
MTMR30.765
SEMA4B0.762
JARID20.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.481
OR4F29-0.453
CETP-0.351
RERGL-0.317
XCL2-0.292
GZMA-0.288
CLIC3-0.275
GADL1-0.265
KRTAP1-1-0.255
FCRL1-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of GAN mRNA25088246
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of GAN mRNA"27567155
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GAN gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GAN mRNA19770486
C006780bisphenol Abisphenol A results in decreased methylation of GAN promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of GAN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GAN gene28505145
D019327Copper SulfateCopper Sulfate results in increased expression of GAN mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of GAN mRNA25562108
D018119StavudineStavudine results in decreased expression of GAN mRNA19398414
D018119StavudineStavudine results in decreased expression of GAN protein19398414
C024629dimethyl phthalatedimethyl phthalate affects the expression of GAN mRNA26924002
C544151jinfukangjinfukang results in decreased expression of GAN mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GAN mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GAN mRNA"25620056
C029938nickel sulfatenickel sulfate results in increased expression of GAN mRNA22714537
D010634PhenobarbitalPhenobarbital affects the expression of GAN mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GAN mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of GAN mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of GAN mRNA22714537
D011794QuercetinQuercetin results in increased expression of GAN mRNA21632981
C031389resorcinolresorcinol results in decreased expression of GAN mRNA22623647
D012822Silicon DioxideSilicon Dioxide results in increased expression of GAN mRNA23221170
D012834SilverSilver results in decreased expression of GAN mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of GAN mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GAN mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GAN mRNA21889950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GAN mRNA22298810
D014520UrethaneUrethane results in increased expression of GAN mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of GAN mRNA23179753
D014638VanadatesVanadates results in decreased expression of GAN mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI12147674  16227972  16303566  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0016567protein ubiquitination-IDA15983046  
GO:0016567protein ubiquitination-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19424503  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0031463Cul3-RING ubiquitin ligase complex-IDA15983046  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18405159[Acupuncture combined with auricular point sticking and pressing for smoking cessation of 53 cases in Russia]. (2008 Feb)Song LZZhongguo Zhen Jiu
28713991Pien Tze Huang Gan Bao attenuates carbon tetrachlorideinduced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress. (2017 Sep)Zhao JMol Med Rep
9666272Cocaine enhances monocyte migration across the blood-brain barrier. Cocaine's connection to AIDS dementia and vasculitis? (1998)Fiala MAdv Exp Med Biol