Gene info: ID 814

Gene: CAMK4

GENE ID: 814

Synonyms: CaMK IV|CaMK-GR|caMK

Description: calcium/calmodulin dependent protein kinase IV

Gene type: protein-coding

Location: 5q22.1

dbXrefs: Ensembl:ENSG00000152495 MIM:114080 Vega:OTTHUMG00000128792 UniprotKB:Q16566

RefSeq: NC_000005.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.901e-1 (AD) 7.662e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DGKB	0.952
AKAP5	0.946
GABRA4	0.941
NDST3	0.94
C11orf87	0.936
MAL2	0.934
EPB41L4B	0.933
CDH8	0.933
ST8SIA3	0.932
STYK1	0.932

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYL3	-0.603
CSAG1	-0.597
ROM1	-0.571
RAB13	-0.569
RNF135	-0.548
CNN2	-0.547
EMP3	-0.542
HEBP2	-0.54
WWTR1	-0.539
HEY2	-0.539

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB07664	5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE	Small Molecule		Experimental	Target
DB07676	3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CAMK4 mRNA	19933214
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK4 mRNA"	25510870
C104006	2',3',4',5'-tetrachloro-4-biphenylol	"2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Diethylstilbestrol results in increased activity of CAMK4 protein]"	16413991
C104006	2',3',4',5'-tetrachloro-4-biphenylol	"2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol results in increased activity of CAMK4 protein]"	16413991
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK4 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK4 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK4 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK4 mRNA"	25510870
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CAMK4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CAMK4 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of CAMK4 mRNA	25458485
C103303	alitretinoin	CAMK4 protein promotes the reaction [alitretinoin results in increased activity of RARA protein]	15773917
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of CAMK4 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CAMK4 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of CAMK4 protein	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CAMK4 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CAMK4 mRNA	19410645\|2483196
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CAMK4 protein	19410645\|2682102
C015001	arsenite	arsenite results in decreased expression of CAMK4 mRNA	23974009
D004958	Estradiol	"2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol results in increased activity of CAMK4 protein]"	16413991
D004958	Estradiol	Estradiol results in increased activity of CAMK4 protein	16413991
C006780	bisphenol A	bisphenol A results in decreased expression of CAMK4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of CAMK4 mRNA	29097150
C054133	casticin	casticin results in decreased expression of CAMK4 mRNA	27862857
D003024	Clozapine	Clozapine results in decreased expression of CAMK4 protein	19289156
D003024	Clozapine	Clozapine results in increased expression of CAMK4 mRNA	15860345
D003042	Cocaine	CAMK4 promoter SNP results in increased susceptibility to Cocaine	19001277
D003042	Cocaine	CAMK4 protein results in decreased susceptibility to Cocaine	19001277
D016572	Cyclosporine	Cyclosporine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]	11073891
D003907	Dexamethasone	Dexamethasone results in decreased expression of CAMK4 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CAMK4 mRNA]	20032058
D003976	Diazinon	Diazinon results in decreased expression of CAMK4 mRNA	23212306
D004054	Diethylstilbestrol	"2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Diethylstilbestrol results in increased activity of CAMK4 protein]"	16413991
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased activity of CAMK4 protein	16413991
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]	17973980
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CAMK4 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMK4 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CAMK4 mRNA	29097150
C540355	fenamidone	fenamidone results in decreased expression of CAMK4 mRNA	27029645
D005473	Fluoxetine	Fluoxetine results in decreased expression of CAMK4 mRNA	17033635
D005473	Fluoxetine	Fluoxetine results in increased phosphorylation of and results in increased activity of CAMK4 protein	15138445
C069837	fullerene C60	fullerene C60 results in decreased expression of CAMK4 mRNA	19167457
C039281	furan	furan results in increased methylation of CAMK4 gene	22079235
D005839	Gentamicins	Gentamicins results in increased expression of CAMK4 mRNA	22061828
C004312	glycidol	glycidol results in decreased expression of CAMK4 mRNA	24915197
D006220	Haloperidol	Haloperidol results in decreased expression of CAMK4 protein	19289156
D006220	Haloperidol	Haloperidol results in increased expression of CAMK4 mRNA	15860345
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CAMK4 protein	21179406
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAMK4 mRNA	25613284
D007608	Kainic Acid	Kainic Acid results in decreased expression of CAMK4 mRNA	17997037
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of CAMK4 mRNA	16807920
C063302	KN 62	KN 62 inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]	11073891
C063302	KN 62	KN 62 results in decreased activity of CAMK4 protein	23435869
C063302	KN 62	[KN 62 results in decreased activity of CAMK4 protein] which results in decreased susceptibility to resveratrol	23435869
C072105	KN 93	KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]	17973980
D007811	Lanthanum	Lanthanum results in decreased phosphorylation of CAMK4 protein	21695898
C028521	lanthanum chloride	lanthanum chloride results in decreased phosphorylation of CAMK4 protein	19643171
D008094	Lithium	Lithium results in increased expression of CAMK4 mRNA	19711354
D008094	Lithium	Lithium results in increased expression of CAMK4 protein	19711354
C008493	methylselenic acid	methylselenic acid results in increased expression of CAMK4 mRNA	12517777
D009151	Mustard Gas	Mustard Gas results in decreased expression of CAMK4 mRNA	15674843
D009529	Nicardipine	Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]	11073891
D009532	Nickel	Nickel results in increased expression of CAMK4 mRNA	24768652\|2558310
D009538	Nicotine	Nicotine results in decreased expression of CAMK4 mRNA	17997037
D010126	Ozone	Ozone results in decreased expression of CAMK4 mRNA	16330353
D052638	Particulate Matter	Particulate Matter results in increased expression of CAMK4 mRNA	19653804
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK4 mRNA"	25510870
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CAMK4 mRNA	26300304
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CAMK4 protein	26300304
D010634	Phenobarbital	Phenobarbital results in decreased expression of CAMK4 mRNA	12807726
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CAMK4 mRNA	24780913
D020891	Raclopride	Raclopride results in decreased expression of CAMK4 protein	19289156
C059514	resveratrol	[KN 62 results in decreased activity of CAMK4 protein] which results in decreased susceptibility to resveratrol	23435869
D018967	Risperidone	Risperidone results in decreased expression of CAMK4 protein	19289156
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CAMK4 protein	28918527
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CAMK4 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMK4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]	17973980
D013749	Tetrachlorodibenzodioxin	KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]	17973980
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the localization of CAMK4 protein	17973980
D013749	Tetrachlorodibenzodioxin	Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]	17973980
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAMK4 mRNA	25613284
D013779	Tetrodotoxin	Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]	17973980
D019284	Thapsigargin	Thapsigargin inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]	11073891
D014050	Toluene	Toluene results in increased expression of CAMK4 mRNA	16737738\|1787017
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CAMK4 mRNA"	19682533
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CAMK4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of CAMK4 mRNA	26272509
C012589	trichostatin A	trichostatin A results in increased expression of CAMK4 mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CAMK4 mRNA	19042947
D014415	Tunicamycin	Tunicamycin results in decreased expression of CAMK4 mRNA	17127020
D014635	Valproic Acid	Valproic Acid results in decreased expression of CAMK4 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of CAMK4 mRNA	24383497\|2493525
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of CAMK4 mRNA	23940539
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of CAMK4 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CAMK4 mRNA	19653804
D014700	Verapamil	Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]	11073891
C111237	vorinostat	vorinostat results in decreased expression of CAMK4 mRNA	27188386
C088658	zoledronic acid	zoledronic acid results in decreased expression of CAMK4 protein	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004683	calmodulin-dependent protein kinase activity	-	IBA	21873635
GO:0004683	calmodulin-dependent protein kinase activity	-	IDA	8107230
GO:0005516	calmodulin binding	-	IBA	21873635
GO:0005524	ATP binding	-	IEA	-
GO:0009931	calcium-dependent protein serine/threonine kinase activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002250	adaptive immune response	-	IEA	-
GO:0002372	myeloid dendritic cell cytokine production	NOT	IMP	17909078
GO:0006468	protein phosphorylation	-	TAS	8089075
GO:0006954	inflammatory response	-	IEA	-
GO:0007165	signal transduction	-	TAS	8089075
GO:0007616	long-term memory	-	IGI	18829949
GO:0018105	peptidyl-serine phosphorylation	-	IBA	21873635
GO:0033081	regulation of T cell differentiation in thymus	-	TAS	18930438
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0043011	myeloid dendritic cell differentiation	-	IMP	17909078
GO:0045670	regulation of osteoclast differentiation	-	TAS	18930438
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	8855261
GO:0046777	protein autophosphorylation	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001650	fibrillar center	-	IDA	-
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04380	Osteoclast differentiation
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-111885	Opioid Signalling	IEA
R-HSA-111885	Opioid Signalling	TAS
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	IEA
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	TAS
R-HSA-111933	Calmodulin induced events	IEA
R-HSA-111933	Calmodulin induced events	TAS
R-HSA-111996	Ca-dependent events	IEA
R-HSA-111996	Ca-dependent events	TAS
R-HSA-111997	CaM pathway	IEA
R-HSA-111997	CaM pathway	TAS
R-HSA-112040	G-protein mediated events	IEA
R-HSA-112040	G-protein mediated events	TAS
R-HSA-112043	PLC beta mediated events	IEA
R-HSA-112043	PLC beta mediated events	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	IEA
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112315	Transmission across Chemical Synapses	IEA
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-1489509	DAG and IP3 signaling	IEA
R-HSA-1489509	DAG and IP3 signaling	TAS
R-HSA-1592230	Mitochondrial biogenesis	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-438064	Post NMDA receptor activation events	IEA
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	TAS
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	IEA
R-HSA-442745	Activation of CaMK IV	TAS
R-HSA-442745	Activation of CaMK IV	IEA
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	IEA
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19001277	Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. (2008 Nov 11)	Bilbao A	Proc Natl Acad Sci U S A
18606955	Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. (2008 Jul)	Schumann G	Arch Gen Psychiatry