Gene: POLR2M

81488
GCOM1|GRINL1A|Gdown|Gdown1
RNA polymerase II subunit M
protein-coding
15q21.3
Ensembl:ENSG00000255529 MIM:606485 Vega:OTTHUMG00000166486 UniprotKB:P0CAP2
NG_029676.1
SNP Mapped
0   ANCO-SNPs
CD|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.280e-2 (AD)  1.508e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2E10.911
HNRNPR0.894
PCNP0.893
PCGF50.893
UFM10.891
RAD210.89
CMPK10.884
EXOC50.876
SMAD20.874
FAM149B10.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.706
OR4F5-0.677
RNF223-0.234
MMP23B-0.231
EPPIN-0.215
SDIM1-0.207
MTRNR2L10-0.192
PTGDR2-0.182
RAX2-0.176
SLC7A9-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of POLR2M mRNA"21346803
D020106AcrylamideAcrylamide results in increased expression of POLR2M mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of POLR2M mRNA16483693
C006780bisphenol Abisphenol A affects the expression of POLR2M mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of POLR2M mRNA24763279
C018021cobaltous chloridecobaltous chloride results in increased expression of POLR2M mRNA19376846
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of POLR2M mRNA24690739
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of POLR2M mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of POLR2M mRNA28302478
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of POLR2M mRNA24690739
D004237DiuronDiuron results in increased expression of POLR2M mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of POLR2M protein23301498
D000431EthanolEthanol results in increased expression of POLR2M mRNA20655511
D018120FinasterideFinasteride results in increased expression of POLR2M mRNA24136188
D005485FlutamideFlutamide results in increased expression of POLR2M mRNA24136188
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of POLR2M mRNA24763279
C544151jinfukangjinfukang results in decreased expression of POLR2M mRNA27392435
C045463leflunomideleflunomide results in increased expression of POLR2M mRNA24136188
D008727MethotrexateMethotrexate results in decreased expression of POLR2M mRNA24449571
D010795Phthalic AcidsPhthalic Acids results in increased expression of POLR2M mRNA21061450
D059808PolyphenolsPolyphenols results in decreased expression of POLR2M mRNA16293270
D011374ProgesteroneProgesterone results in increased expression of POLR2M mRNA21770760
D015474IsotretinoinIsotretinoin results in increased expression of POLR2M mRNA20436886
D012643SeleniumSelenium results in decreased expression of POLR2M mRNA19244175
D012834SilverSilver results in decreased expression of POLR2M mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POLR2M mRNA18796159
D013853ThioacetamideThioacetamide results in increased expression of POLR2M mRNA23411599
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of POLR2M gene25560391
C025643vinclozolinvinclozolin affects the expression of POLR2M mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003899DNA-directed 5'-3' RNA polymerase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032774RNA biosynthetic process-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0051685maintenance of ER location-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IBA21873635  
GO:0005635nuclear envelope-IBA21873635  
GO:0005635nuclear envelope-IDA-  
GO:0016591DNA-directed RNA polymerase II, holoenzyme-IBA21873635  
GO:0016591DNA-directed RNA polymerase II, holoenzyme-IDA22231121  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal