Gene: CFHR5

81494
CFHL5|CFHR5D|FHR-5|FHR5
complement factor H related 5
protein-coding
1q31.3
Ensembl:ENSG00000134389 MIM:608593 Vega:OTTHUMG00000036517 UniprotKB:Q9BXR6
NG_016365.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.171e-2 (AD)  8.712e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL12A10.495
CPZ0.469
TECTA0.46
ST8SIA50.448
SLC44A50.442
SCLT10.441
PP2D10.438
AKR1E20.436
SPAG60.432
IL17REL0.429

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOD-0.366
CCDC102A-0.341
EYA2-0.32
FGF11-0.316
SH2D4A-0.309
NQO1-0.309
LRP5-0.309
RAB13-0.308
DLEU1-0.308
TBL1X-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CFHR5 mRNA"19692669
D000082AcetaminophenAcetaminophen results in decreased expression of CFHR5 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CFHR5 mRNA27153756
D016572CyclosporineCyclosporine results in decreased expression of CFHR5 mRNA27989131
D008727MethotrexateMethotrexate results in decreased expression of CFHR5 mRNA24449571
C568376MT19c compoundMT19c compound results in decreased expression of CFHR5 mRNA21781307
D014635Valproic AcidValproic Acid results in decreased expression of CFHR5 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of CFHR5 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23487775  25910212  
GO:0042803protein homodimerization activity-IMP23487775  
GO:0046982protein heterodimerization activity-IDA23487775  
GO ID GO Term Qualifier Evidence PubMed
GO:0006957complement activation, alternative pathway-NAS11058592  
GO:0030449regulation of complement activation-TAS-  
GO:0032091negative regulation of protein binding-IDA23487775  
GO:0045919positive regulation of cytolysis-IMP23487775  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS11058592  
GO:0005576extracellular region-TAS-  
GO:0032991protein-containing complex-IMP23487775  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21807600Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. (2011 Jul)Hageman GSHum Genomics
18541031The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)Zhang HBMC Med Genet