Gene info: ID 815

Gene: CAMK2A

GENE ID: 815

Synonyms: CAMKA|MRD53

Description: calcium/calmodulin dependent protein kinase II alpha

Gene type: protein-coding

Location: 5q32

dbXrefs: Ensembl:ENSG00000070808 MIM:114078 Vega:OTTHUMG00000134281 UniprotKB:Q9UQM7

RefSeq: NG_047040.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.331e-3 (AD) 9.152e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNAB2	0.967
PACSIN1	0.965
SEPT5	0.965
JPH4	0.959
CPLX2	0.958
SNPH	0.956
JPH3	0.952
CBX6	0.952
FBXO41	0.952
DLG4	0.95

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.685
OR4F29	-0.636
TFPI2	-0.491
C9orf135	-0.485
IGF2BP2	-0.458
SGMS2	-0.451
ANXA13	-0.449
SNHG18	-0.446
SLC51B	-0.437
C1orf87	-0.434

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04119	Hexatantalum Dodecabromide	Small Molecule		Experimental	Target
DB04447	1,4-Dithiothreitol	Small Molecule	3483-12-3	Experimental	Target
DB07766	(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]"	28025122
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of CAMK2A protein]"	21933187
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]"	19217379
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK2A mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CAMK2A protein modified form"	17589592
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK2A mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK2A mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK2A mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK2A mRNA"	25510870
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]	21933187
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CAMK2A mRNA	16788091
C057013	7-chlorokynurenic acid	7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]	17609678
D000082	Acetaminophen	Acetaminophen affects the expression of CAMK2A mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of CAMK2A mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of CAMK2A mRNA	28959563
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of CAMK2A mRNA	21298039
D000638	Amiodarone	Amiodarone affects the expression of CAMK2A mRNA	25064622
D000638	Amiodarone	Amiodarone results in increased expression of CAMK2A mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CAMK2A mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of CAMK2A gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CAMK2A protein	24831965
D001280	Atrazine	Atrazine results in decreased expression of CAMK2A mRNA	25929836
C072763	azamethiphos	azamethiphos promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]	28385489
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CAMK2A mRNA	21839799
D004958	Estradiol	Estradiol results in increased expression of CAMK2A mRNA	20068009
D001688	Biological Products	Biological Products results in increased phosphorylation of CAMK2A protein	23266269
C006780	bisphenol A	bisphenol A results in decreased expression of CAMK2A protein	22981971
C006780	bisphenol A	bisphenol A results in increased expression of CAMK2A mRNA	25103225
C006780	bisphenol A	bisphenol A results in increased phosphorylation of CAMK2A protein	25103225
C006780	bisphenol A	[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]	25103225
C006780	bisphenol A	KN 93 inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]	25103225
C006780	bisphenol A	Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]	25103225
C006780	bisphenol A	bisphenol A results in decreased expression of CAMK2A mRNA	24066056\|2518105
C006780	bisphenol A	bisphenol A results in increased expression of CAMK2A mRNA	29097150
D002104	Cadmium	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of CAMK2A protein]"	21933187
D019256	Cadmium Chloride	2-aminoethoxydiphenyl borate inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]	21933187
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein	21933187
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of CAMK2A protein	19233221
D019256	Cadmium Chloride	CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]	21933187
D019256	Cadmium Chloride	CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]	21933187
D019256	Cadmium Chloride	CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein]	21933187
D019256	Cadmium Chloride	CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]	21933187
D019256	Cadmium Chloride	CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]	21933187
D019256	Cadmium Chloride	CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]	21933187
D019256	Cadmium Chloride	CAMK2A mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]	21933187
D019256	Cadmium Chloride	KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]	21933187
D019256	Cadmium Chloride	pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	21933187
D019256	Cadmium Chloride	Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	21933187
D019256	Cadmium Chloride	Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	19233221
D019256	Cadmium Chloride	U 0126 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	21933187
D002211	Capsaicin	Capsaicin results in increased phosphorylation of and results in increased expression of CAMK2A protein	12019337
D002746	Chlorpromazine	Chlorpromazine affects the expression of CAMK2A mRNA	25064622
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CAMK2A mRNA	20350560
D004390	Chlorpyrifos	Chlorpyrifos promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]	28385489
D003024	Clozapine	Clozapine results in decreased expression of CAMK2A mRNA	17266109
D003024	Clozapine	Clozapine results in increased expression of CAMK2A mRNA	17266109
D003024	Clozapine	Clozapine results in decreased expression of CAMK2A protein	19289156
D003024	Clozapine	Clozapine results in increased expression of CAMK2A mRNA	15860345
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CAMK2A mRNA	19376846
D003042	Cocaine	CAMK2A affects the susceptibility to Cocaine	14725635
D003042	Cocaine	Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein	28194001
D003042	Cocaine	Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]	28194001
D003042	Cocaine	7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]	17609678
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]	19217379
D003042	Cocaine	Cocaine results in increased expression of CAMK2A protein	14725635
D003042	Cocaine	Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein	17609678
D003042	Cocaine	KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]	19217379
D003042	Cocaine	Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]	17609678
D003300	Copper	Copper deficiency results in increased expression of CAMK2A mRNA	26033743
D003471	Cuprizone	Cuprizone results in decreased expression of CAMK2A mRNA	26577399
D003474	Curcumin	[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA	22911773
D016572	Cyclosporine	Cyclosporine affects the expression of CAMK2A mRNA	25064622
D016572	Cyclosporine	Cyclosporine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]	11073891
C037304	cyhalothrin	cyhalothrin promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]	28385489
C037304	cyhalothrin	cyhalothrin results in decreased expression of CAMK2A protein	28487251
C010902	decabromobiphenyl ether	decabromobiphenyl ether metabolite results in increased expression of CAMK2A protein	19380496
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CAMK2A protein	25194327
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CAMK2A mRNA	23640034
D013759	Dronabinol	Dronabinol results in decreased expression of CAMK2A mRNA	21955143
D002945	Cisplatin	Cisplatin results in decreased expression of CAMK2A mRNA	23558232
D002945	Cisplatin	trichostatin A inhibits the reaction [Cisplatin results in decreased expression of CAMK2A mRNA]	23558232
D004026	Dieldrin	Dieldrin affects the expression of CAMK2A mRNA	22546817
D004041	Dietary Fats	Dietary Fats results in increased expression of CAMK2A mRNA	25016146
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of CAMK2A mRNA	26033743
C058705	diethyl malate	diethyl malate affects the expression of CAMK2A mRNA	24814887
C058705	diethyl malate	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA]	24814887
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of CAMK2A gene	23968726
D004054	Diethylstilbestrol	Diethylstilbestrol promotes the reaction [CAMK2A protein results in increased phosphorylation of CAMK2A protein]	17184923
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased activity of CAMK2A protein	17184923
D008559	Memantine	Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]	24333387
D008559	Memantine	Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]	24333387
D004221	Disulfiram	Disulfiram results in decreased expression of CAMK2A mRNA	20530235
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D004281	Docosahexaenoic Acids	[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA	22911773
D004298	Dopamine	[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]	19217379
D004533	Egtazic Acid	Egtazic Acid inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]	11073891
C508214	(E)-N1-((6-chloro-3-pyridyl)methyl)-N2-cyano-N1-methylacetamidine	(E)-N1-((6-chloro-3-pyridyl)methyl)-N2-cyano-N1-methylacetamidine promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]	28385489
D000431	Ethanol	Ethanol results in increased expression of CAMK2A mRNA	21955143
D000431	Ethanol	Ethanol results in decreased expression of CAMK2A mRNA	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CAMK2A mRNA	25064622
D018683	Excitatory Amino Acid Agents	Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D018683	Excitatory Amino Acid Agents	Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
D018683	Excitatory Amino Acid Agents	KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D005411	Flame Retardants	Flame Retardants results in decreased expression of CAMK2A protein modified form	17589592
D005481	Flurothyl	Flurothyl results in decreased expression of CAMK2A mRNA	19059322
C071658	FPL 64176	FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
C071658	FPL 64176	Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D006220	Haloperidol	Haloperidol results in decreased expression of and results in decreased phosphorylation of CAMK2A protein	18061412
D006220	Haloperidol	Haloperidol results in decreased expression of CAMK2A protein	19289156
D006220	Haloperidol	Haloperidol results in increased expression of CAMK2A mRNA	15860345
D006533	Heptachlor	Heptachlor promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]	28385489
D007052	Ibuprofen	Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]	24333387
D007052	Ibuprofen	Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]	24333387
D007213	Indomethacin	Indomethacin results in decreased expression of CAMK2A mRNA	28201806
D015759	Ionomycin	[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]	19217379
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein binds to ACTN1 protein]	19217379
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein binds to CDK5R1 protein]	19217379
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein binds to GRIN2B protein]	19217379
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]	19217379
D015759	Ionomycin	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D015759	Ionomycin	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]	19217379
D007657	Ketone Bodies	Ketone Bodies results in increased expression of CAMK2A mRNA	16807920
C063302	KN 62	KN 62 inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]	11073891
C072105	KN 93	KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]	28025122
C072105	KN 93	[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]	25103225
C072105	KN 93	KN 93 inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]	25103225
C072105	KN 93	KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]	21933187
C072105	KN 93	KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]	19217379
C072105	KN 93	KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C072105	KN 93	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C072105	KN 93	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]	19217379
C008261	lead acetate	lead acetate results in decreased phosphorylation of CAMK2A protein	23855546
C008261	lead acetate	Quercetin inhibits the reaction [lead acetate results in decreased phosphorylation of CAMK2A protein]	23855546
C008261	lead acetate	lead acetate results in decreased expression of CAMK2A mRNA	22160880
D019808	Losartan	[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]	25103225
D019808	Losartan	Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]	25103225
D008294	Malathion	Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]	28385489
D008345	Manganese	Manganese results in decreased phosphorylation of CAMK2A protein	26616912
D008713	Methimazole	Methimazole results in increased expression of CAMK2A mRNA	22504374
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CAMK2A protein	25809596
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CAMK2A mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CAMK2A mRNA"	20188158
D009020	Morphine	CAMK2A protein affects the susceptibility to Morphine	20053885
D009020	Morphine	Morphine results in increased expression of CAMK2A mRNA	21955143
C489863	myristoylated autocamtide-2-related inhibitory peptide	myristoylated autocamtide-2-related inhibitory peptide inhibits the reaction [Streptozocin results in increased phosphorylation of CAMK2A protein]	20424226
C477659	N-(3-methoxyphenyl)-4-chlorocinnamanilide	N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]	28025122
D009529	Nicardipine	Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]	11073891
D009529	Nicardipine	Nicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]	11073891
D009538	Nicotine	Nicotine results in increased expression of CAMK2A mRNA	21955143
D009543	Nifedipine	Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]	28194001
D009543	Nifedipine	Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C025589	ochratoxin A	ochratoxin A results in increased expression of CAMK2A mRNA	19237604
C076029	olanzapine	olanzapine results in decreased expression of and results in decreased phosphorylation of CAMK2A protein	18061412
D010269	Paraquat	Paraquat affects the expression of CAMK2A mRNA	25064622
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMK2A mRNA"	25510870
D010406	Penicillins	Penicillins results in decreased expression of CAMK2A mRNA	19446251
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CAMK2A protein	21820030
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CAMK2A mRNA	19756518
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CAMK2A protein	20127074
D010622	Phencyclidine	Phencyclidine results in decreased expression of CAMK2A mRNA	17266109
D010622	Phencyclidine	Phencyclidine results in increased expression of CAMK2A mRNA	17266109
D010656	Phenylephrine	Phenylephrine results in decreased expression of CAMK2A mRNA	18158353
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of CAMK2A gene	23968726
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CAMK2A mRNA	19710929
C006253	pirinixic acid	NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of CAMK2A mRNA]	17950772
C006253	pirinixic acid	pirinixic acid results in decreased expression of CAMK2A mRNA	17950772
C108953	platycodin D	platycodin D results in increased phosphorylation of CAMK2A protein	23319015
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CAMK2A mRNA	22504374
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	21933187
D001498	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of CAMK2A protein"	28194001
D011794	Quercetin	Quercetin inhibits the reaction [lead acetate results in decreased phosphorylation of CAMK2A protein]	23855546
C059514	resveratrol	resveratrol inhibits the reaction [Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A protein]	20424226
D018967	Risperidone	Risperidone results in decreased expression of CAMK2A protein	19289156
D012402	Rotenone	Rotenone results in decreased expression of CAMK2A mRNA	23186747
D012402	Rotenone	Rotenone results in increased expression of CAMK2A mRNA	22526376
C560377	rutacarpine	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]"	28025122
C560377	rutacarpine	KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]	28025122
C560377	rutacarpine	N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]	28025122
C560377	rutacarpine	rutacarpine results in increased phosphorylation of CAMK2A protein	28025122
C560377	rutacarpine	W 7 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]	28025122
C065299	S-allylcysteine	S-allylcysteine results in increased phosphorylation of CAMK2A protein	23465592
C534628	SCH 23390	SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA]	24814887
D020123	Sirolimus	Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	21933187
C080703	SK&F 83959	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]"	19217379
C080703	SK&F 83959	SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C080703	SK&F 83959	SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
C017947	sodium arsenite	sodium arsenite affects the methylation of CAMK2A gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased phosphorylation of CAMK2A protein	22421273
D020160	Sodium Benzoate	Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]	17609678
D013311	Streptozocin	myristoylated autocamtide-2-related inhibitory peptide inhibits the reaction [Streptozocin results in increased phosphorylation of CAMK2A protein]	20424226
D013311	Streptozocin	resveratrol inhibits the reaction [Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A protein]	20424226
D013311	Streptozocin	Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A protein	20424226
D013311	Streptozocin	Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]	24333387
D013311	Streptozocin	Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]	24333387
D013311	Streptozocin	Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]	24333387
D013311	Streptozocin	Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]	24333387
D013311	Streptozocin	Streptozocin results in decreased expression of CAMK2A mRNA	24333387
D013311	Streptozocin	Streptozocin results in decreased expression of CAMK2A protein	24333387
D013458	Sulfur Dioxide	Sulfur Dioxide results in decreased expression of CAMK2A protein modified form	25534910
D013752	Tetracycline	Tetracycline affects the expression of CAMK2A mRNA	25064622
D013853	Thioacetamide	Thioacetamide affects the expression of CAMK2A mRNA	25064622
D013893	Thiram	Thiram results in decreased expression of CAMK2A mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of CAMK2A mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CAMK2A mRNA	28111298
C012589	trichostatin A	trichostatin A inhibits the reaction [Cisplatin results in decreased expression of CAMK2A mRNA]	23558232
C012589	trichostatin A	trichostatin A results in decreased expression of CAMK2A mRNA	23558232
D014268	Trifluoperazine	Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	19233221
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CAMK2A protein"	24717766
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CAMK2A mRNA"	24717766
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of CAMK2A mRNA	24717766
C113580	U 0126	U 0126 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]	21933187
D014635	Valproic Acid	Valproic Acid affects the expression of CAMK2A mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in increased methylation of CAMK2A gene	29154799
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride results in increased expression of CAMK2A mRNA	25423262
D014700	Verapamil	Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]	11073891
D014700	Verapamil	Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]	11073891
C025643	vinclozolin	vinclozolin affects the expression of CAMK2A mRNA	19015723
C017967	W 7	W 7 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]	28025122

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	ISS	-
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004683	calmodulin-dependent protein kinase activity	-	IBA	21873635
GO:0004683	calmodulin-dependent protein kinase activity	-	IMP	18305109
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005515	protein binding	-	IPI	12223541 17052756 17353931 18305109 19453375 20668654 25241761 25852190 27173435 29426014
GO:0005516	calmodulin binding	-	IBA	21873635
GO:0005516	calmodulin binding	-	IPI	20668654
GO:0005524	ATP binding	-	IEA	-
GO:0009931	calcium-dependent protein serine/threonine kinase activity	-	IMP	18305109
GO:0016301	kinase activity	-	IDA	17052756
GO:0035254	glutamate receptor binding	-	ISS	-
GO:0042802	identical protein binding	-	IPI	20668654 21884935
GO:0042803	protein homodimerization activity	-	IPI	20668654
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	ISS	-
GO:0000165	MAPK cascade	-	TAS	-
GO:0002931	response to ischemia	-	ISS	-
GO:0006468	protein phosphorylation	-	IDA	17052756
GO:0006468	protein phosphorylation	-	IMP	18305109
GO:0006816	calcium ion transport	-	ISS	-
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	-
GO:0010666	positive regulation of cardiac muscle cell apoptotic process	-	ISS	-
GO:0018105	peptidyl-serine phosphorylation	-	ISS	-
GO:0038166	angiotensin-activated signaling pathway	-	IDA	20584908
GO:0046777	protein autophosphorylation	-	ISS	-
GO:0046928	regulation of neurotransmitter secretion	-	ISS	-
GO:0048168	regulation of neuronal synaptic plasticity	-	ISS	-
GO:0048813	dendrite morphogenesis	-	IEA	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	17052756
GO:0051928	positive regulation of calcium ion transport	-	ISS	-
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	-
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005739	mitochondrion	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0014069	postsynaptic density	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0030666	endocytic vesicle membrane	-	TAS	-
GO:0042734	presynaptic membrane	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635

KEGG ID	KEGG Term
hsa04012	ErbB signaling pathway
hsa04020	Calcium signaling pathway
hsa04114	Oocyte meiosis
hsa04310	Wnt signaling pathway
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04740	Olfactory transduction
hsa04912	GnRH signaling pathway
hsa04916	Melanogenesis
hsa04971	Gastric acid secretion
hsa05214	Glioma

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-3371571	HSF1-dependent transactivation	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-397014	Muscle contraction	TAS
R-HSA-399719	Trafficking of AMPA receptors	TAS
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	TAS
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	TAS
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	TAS
R-HSA-442742	CREB phosphorylation through the activation of Ras	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	TAS
R-HSA-5576891	Cardiac conduction	TAS
R-HSA-5576892	Phase 0 - rapid depolarisation	TAS
R-HSA-5578775	Ion homeostasis	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-936837	Ion transport by P-type ATPases	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25290264	alphaCaMKII controls the establishment of cocaine's reinforcing effects in mice and humans. (2014 Oct 7)	Easton AC	Transl Psychiatry
23459588	alphaCaMKII autophosphorylation controls the establishment of alcohol drinking behavior. (2013 Aug)	Easton AC	Neuropsychopharmacology
28714806	Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex. (2017 Sep)	de Paiva Lima C	J Neurogenet
21611732	Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. (2011 Aug)	Jian XQ	J Abnorm Child Psychol