Gene: NDEL1

81565
EOPA|MITAP1|NDE1L1|NDE2|NUDEL
nudE neurodevelopment protein 1 like 1
protein-coding
17p13.1
Ensembl:ENSG00000166579 MIM:607538 Vega:OTTHUMG00000108193 UniprotKB:Q9GZM8
NG_029963.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.181e-1 (AD)  3.488e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf2160.969
ATP1A10.967
YWHAG0.967
PAK10.966
GLS0.964
MOAP10.963
PPP3CB0.963
ENO20.962
GABARAPL10.961
BTBD100.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.522
OR4F29-0.493
MYL3-0.466
RNF135-0.458
CSAG1-0.457
HEY2-0.455
REST-0.437
MBNL3-0.437
CXCR2-0.432
MTRNR2L10-0.432

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NDEL1 mRNA28329830
D000082AcetaminophenAcetaminophen results in increased expression of NDEL1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of NDEL1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NDEL1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NDEL1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NDEL1 mRNA16483693
D001151ArsenicArsenic affects the methylation of NDEL1 gene25304211
C547126AZM551248AZM551248 results in decreased expression of NDEL1 mRNA22323515
C044887beta-methylcholinebeta-methylcholine affects the expression of NDEL1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of NDEL1 mRNA25047013
C006780bisphenol Abisphenol A results in increased expression of NDEL1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NDEL1 mRNA21297351
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NDEL1 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of NDEL1 mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of NDEL1 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of NDEL1 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NDEL1 mRNA21266533
D002945CisplatinCisplatin affects the expression of NDEL1 mRNA23300844
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NDEL1 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of NDEL1 mRNA26924002
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NDEL1 mRNA28329830
D005947GlucoseGlucose results in increased expression of NDEL1 mRNA17178593
D017313FenretinideFenretinide results in increased expression of NDEL1 mRNA28973697
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NDEL1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NDEL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NDEL1 mRNA"25554681
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of NDEL1 mRNA17616710
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of NDEL1 mRNA18593933
D010634PhenobarbitalPhenobarbital results in decreased expression of NDEL1 mRNA23091169
D011192Potassium DichromatePotassium Dichromate results in increased expression of NDEL1 protein23718831
D012822Silicon DioxideSilicon Dioxide results in increased expression of NDEL1 mRNA19073995
C009277sodium arsenatesodium arsenate results in decreased expression of NDEL1 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of NDEL1 mRNA21795629
D012999SomanSoman results in increased expression of NDEL1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NDEL1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of NDEL1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NDEL1 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NDEL1 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NDEL1 gene27618143
D014520UrethaneUrethane results in increased expression of NDEL1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NDEL1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of NDEL1 mRNA20546886
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NDEL1 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of NDEL1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10931877  12812986  17035248  17043677  17600710  17997972  
19492042  20360068  20880836  25416956  25910212  26496610  
27173435  
GO:0008017microtubule binding-IBA21873635  
GO:0042802identical protein binding-IPI10931877  17997972  25416956  
GO:0043014alpha-tubulin binding-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO:0048487beta-tubulin binding-IEA-  
GO:0070012oligopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000132establishment of mitotic spindle orientation-IBA21873635  
GO:0001764neuron migration-IEA-  
GO:0001833inner cell mass cell proliferation-IEA-  
GO:0006508proteolysis-IEA-  
GO:0007020microtubule nucleation-IBA21873635  
GO:0007059chromosome segregation-IBA21873635  
GO:0007059chromosome segregation-IMP17600710  
GO:0007100mitotic centrosome separation-IBA21873635  
GO:0008090retrograde axonal transport-IEA-  
GO:0008286insulin receptor signaling pathway-IEA-  
GO:0010975regulation of neuron projection development-IBA21873635  
GO:0016477cell migration-IBA21873635  
GO:0021799cerebral cortex radially oriented cell migration-IEA-  
GO:0021955central nervous system neuron axonogenesis-IEA-  
GO:0032418lysosome localization-ISS-  
GO:0033157regulation of intracellular protein transport-IMP21283621  
GO:0043547positive regulation of GTPase activity-IMP21283621  
GO:0045773positive regulation of axon extension-IEA-  
GO:0047496vesicle transport along microtubule-IBA21873635  
GO:0048680positive regulation of axon regeneration-IEA-  
GO:0051081nuclear envelope disassembly-IEA-  
GO:0051303establishment of chromosome localization-IBA21873635  
GO:0051642centrosome localization-IBA21873635  
GO:0060052neurofilament cytoskeleton organization-IEA-  
GO:0090630activation of GTPase activity-IEA-  
GO:1900029positive regulation of ruffle assembly-ISS-  
GO:1990138neuron projection extension-IEA-  
GO:2000574regulation of microtubule motor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IBA21873635  
GO:0000776kinetochore-IDA17600710  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005635nuclear envelope-IEA-  
GO:0005813centrosome-IBA21873635  
GO:0005819spindle-IEA-  
GO:0005829cytosol-TAS-  
GO:0005871kinesin complex-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0008021synaptic vesicle-IEA-  
GO:0031252cell leading edge-IEA-  
GO:0043203axon hillock-IEA-  
GO:0060053neurofilament cytoskeleton-IEA-  
GO:0090724central region of growth cone-IEA-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23388542Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia--a potential biomarker? (2013 May)Gadelha AJ Psychiatr Res