Gene: CLPB

81570
ANKCLB|HSP78|MEGCANN|MGCA7|SKD3
ClpB homolog, mitochondrial AAA ATPase chaperonin
protein-coding
11q13.4
Ensembl:ENSG00000162129 MIM:616254 Vega:OTTHUMG00000167902 UniprotKB:Q9H078
NG_042130.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.703e-1 (AD)  6.432e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53BP10.884
PDP20.864
TNPO30.858
PCDH10.856
KIAA01000.849
HYOU10.845
CANT10.841
AP5B10.841
POM1210.839
CIAO10.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.437
CTNNA3-0.403
APOM-0.398
KLRK1-0.392
OR4F29-0.39
C19orf18-0.373
SH2D1A-0.371
ASB4-0.369
C22orf31-0.361
FGFBP2-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CLPB mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CLPB mRNA"21346803
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLPB mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLPB mRNA26238291
C006780bisphenol Abisphenol A results in decreased expression of CLPB mRNA23798566
C006780bisphenol Abisphenol A results in decreased expression of CLPB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CLPB gene28505145
D002065BuspironeBuspirone results in decreased expression of CLPB mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CLPB promoter22457795
C018021cobaltous chloridecobaltous chloride results in increased expression of CLPB mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of CLPB mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of CLPB mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CLPB mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CLPB mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of CLPB mRNA28302478
C118739entinostatentinostat results in increased expression of CLPB mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CLPB mRNA22079256
D018120FinasterideFinasteride results in increased expression of CLPB mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of CLPB mRNA18035473
D005485FlutamideFlutamide results in increased expression of CLPB mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of CLPB mRNA22634610
D017313FenretinideFenretinide results in decreased expression of CLPB mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CLPB protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CLPB mRNA18951874
D007545IsoproterenolIsoproterenol results in decreased expression of CLPB mRNA20003209
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CLPB mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CLPB mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CLPB mRNA"25554681
D009532NickelNickel results in increased expression of CLPB mRNA24768652|2558310
D010100OxygenOxygen deficiency results in decreased expression of CLPB mRNA26516004
C006253pirinixic acidpirinixic acid results in increased expression of CLPB mRNA18301758
C006253pirinixic acidpirinixic acid results in increased expression of CLPB mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CLPB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CLPB mRNA22079256
D012969Sodium FluorideSodium Fluoride results in increased expression of CLPB protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLPB mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CLPB protein18951874
D013806TheophyllineTheophylline results in increased expression of CLPB mRNA18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CLPB mRNA28065790
D014635Valproic AcidValproic Acid results in increased expression of CLPB mRNA28001369
C025643vinclozolinvinclozolin results in increased expression of CLPB mRNA20566332
D014800VitalliumVitallium analog results in increased expression of CLPB mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of CLPB mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0034605cellular response to heat-IDA2745427  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005739mitochondrion-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
1831555Prevalence, onset, and risk of psychiatric disorders in men with chronic low back pain: a controlled study. (1991 May)Atkinson JHPain