Gene: APOLD1

81575
VERGE
apolipoprotein L domain containing 1
protein-coding
12p13.1
Ensembl:ENSG00000178878 MIM:612456 Vega:OTTHUMG00000153561 UniprotKB:Q96LR9
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11055041chr12:12750648 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27464065chr12:12940610APOLD11.950e-11Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTG20.771
FOXF10.758
SRGN0.754
SIK10.754
ADAMTS10.745
LRRC320.731
ZFP360.726
MCL10.722
CLDN50.718
SLC2A10.713

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC32A1-0.408
KNCN-0.39
SP9-0.388
HCRTR2-0.385
SMIM18-0.379
HAS1-0.376
HNF1A-0.372
CALHM1-0.369
PRLHR-0.367
VAX1-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of APOLD1 mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOLD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOLD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of APOLD1 mRNA21420995
D001151ArsenicArsenic affects the methylation of APOLD1 gene25304211
C006780bisphenol Abisphenol A results in increased expression of APOLD1 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of APOLD1 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of APOLD1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of APOLD1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of APOLD1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of APOLD1 promoter22457795
D002509CephaloridineCephaloridine results in decreased expression of APOLD1 mRNA18500788
D002737ChloropreneChloroprene results in decreased expression of APOLD1 mRNA23125180
D003042CocaineCocaine affects the expression of APOLD1 mRNA20187946
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of APOLD1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of APOLD1 mRNA27392435
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of APOLD1 mRNA17490981
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of APOLD1 mRNA28433925
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of APOLD1 mRNA28433925
C118739entinostatentinostat results in decreased expression of APOLD1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOLD1 mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of APOLD1 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of APOLD1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of APOLD1 mRNA19167457
C004312glycidolglycidol results in decreased expression of APOLD1 mRNA24915197
D017313FenretinideFenretinide results in increased expression of APOLD1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of APOLD1 mRNA26846883
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of APOLD1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of APOLD1 mRNA21889194
C045463leflunomideleflunomide results in increased expression of APOLD1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of APOLD1 mRNA"24972896
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of APOLD1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of APOLD1 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of APOLD1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of APOLD1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of APOLD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of APOLD1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of APOLD1 mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of APOLD1 mRNA17616710
D010100OxygenOxygen deficiency results in increased expression of APOLD1 mRNA20880076
D010126OzoneOzone results in increased expression of APOLD1 mRNA28623178
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of APOLD1 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOLD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of APOLD1 mRNA26272509
C005556propionaldehydepropionaldehyde results in increased expression of APOLD1 mRNA26079696
D011794QuercetinQuercetin results in increased expression of APOLD1 mRNA21632981
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of APOLD1 mRNA19564919
D012822Silicon DioxideSilicon Dioxide results in decreased expression of APOLD1 mRNA25351596
D012834SilverSilver results in decreased expression of APOLD1 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of APOLD1 mRNA21795629
D053260SootSoot results in increased expression of APOLD1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APOLD1 mRNA19933214
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of APOLD1 mRNA28065790
D014212TretinoinTretinoin results in increased expression of APOLD1 mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of APOLD1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of APOLD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of APOLD1 mRNA23179753|2718838
D014750VincristineVincristine results in increased expression of APOLD1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IBA21873635  
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IBA21873635  
GO:0001525angiogenesis-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0006869lipid transport-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0042118endothelial cell activation-IEA-  
GO:0042157lipoprotein metabolic process-IEA-  
GO:0045601regulation of endothelial cell differentiation-IBA21873635  
GO:0045601regulation of endothelial cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal