Gene: COIL

8161
CLN80|p80-coilin
coilin
protein-coding
17q22
Ensembl:ENSG00000121058 MIM:600272 Vega:OTTHUMG00000178126 UniprotKB:P38432
NC_000017.11
PubMed
CD|ND|AD
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.183e-1 (AD)  6.429e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC5L0.939
THUMPD10.937
POLR2B0.937
LEPROTL10.936
CUL30.936
JKAMP0.934
KPNA30.934
TAX1BP10.934
BTF3L40.931
USP100.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.621
OR4F29-0.561
MTRNR2L10-0.346
MTRNR2L9-0.345
MTRNR2L6-0.341
CSAG1-0.288
MTRNR2L3-0.278
MTRNR2L8-0.271
RSPO1-0.271
KLRB1-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of COIL mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of COIL mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of COIL mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of COIL mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of COIL mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of COIL mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COIL mRNA22228805
D004958EstradiolEstradiol results in decreased expression of COIL mRNA20068009
C006780bisphenol Abisphenol A affects the expression of COIL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of COIL mRNA25181051
D003024ClozapineClozapine results in increased expression of COIL mRNA16715494
D003042CocaineCocaine affects the expression of COIL mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of COIL mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of COIL mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of COIL mRNA24317228
D002945CisplatinCisplatin results in increased expression of COIL mRNA27392435
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of COIL protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of COIL mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of COIL mRNA20655997
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of COIL mRNA22634610
D006220HaloperidolHaloperidol results in increased expression of COIL mRNA16715494
C492448ICG 001ICG 001 results in decreased expression of COIL mRNA26191083
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of COIL mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of COIL mRNA23649840
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of COIL mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in increased expression of COIL protein23718831
D011794QuercetinQuercetin results in decreased expression of COIL mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of COIL mRNA21427059
D012999SomanSoman results in decreased expression of COIL mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COIL mRNA21570461
D014212TretinoinTretinoin results in decreased expression of COIL mRNA21934132
C012589trichostatin Atrichostatin A affects the expression of COIL mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of COIL mRNA24935251
D014520UrethaneUrethane results in decreased expression of COIL mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of COIL mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of COIL mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of COIL mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of COIL mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12757932  16079131  16713569  21070772  21072240  21920476  
23685356  25416956  27107012  27107014  
GO:0008022protein C-terminus binding-IPI12757932  
GO:0042802identical protein binding-IPI16713569  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA19734146  
GO:0005654nucleoplasm-IDA12757932  
GO:0005730nucleolus-IDA12757932  
GO:0015030Cajal body-IDA12757932  16687569  17577209  
GO:0016020membrane-HDA19946888  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26531241The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer. (2016 Jan)Jiang FOncol Rep
26893834Association of genetic variants with atrial fibrillation. (2016 Feb)Yamase YBiomed Rep
26493334Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. (2016 Jan)Nakagawa IJ Stroke Cerebrovasc Dis
24273408Brain volumes and neuropsychological performance are related to current smoking and alcoholism history. (2013)Luhar RBNeuropsychiatr Dis Treat
26405538Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. (2015 Sep)Ueyama CBiomed Rep
24907955Assessment of risk factors against severity of COPD in non-smokers. (2013 Jul-Sep)Panjwani AKJNMA J Nepal Med Assoc
25730614Deep TMS on alcoholics: effects on cortisolemia and dopamine pathway modulation. A pilot study. (2015 Apr)Ceccanti MCan J Physiol Pharmacol
25380619ROCK1 as a novel prognostic marker in vulvar cancer. (2014 Nov 7)Akagi EMBMC Cancer
3974683Primary tubal infertility in relation to the use of an intrauterine device. (1985 Apr 11)Daling JRN Engl J Med
11952537Expression of nicotinic receptors in the skin of patients with palmoplantar pustulosis. (2002 Mar)Hagforsen EBr J Dermatol
25607530Clinical and tumor significance of tropomyosin-1 expression levels in renal cell carcinoma. (2015 Mar)Wang JOncol Rep
10730754The distribution of choline acetyltransferase- and acetylcholinesterase-like immunoreactivity in the palmar skin of patients with palmoplantar pustulosis. (2000 Feb)Hagforsen EBr J Dermatol
3974684Tubal infertility and the intrauterine device. (1985 Apr 11)Cramer DWN Engl J Med
24568560Acquired defects in CFTR-dependent beta-adrenergic sweat secretion in chronic obstructive pulmonary disease. (2014 Feb 25)Courville CARespir Res
26762739Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (2016 Jan)Liu YJ Thorac Oncol
25637605Genetic variation associates with susceptibility for cigarette smoke-induced neutrophilia in mice. (2015 Apr 1)Pouwels SDAm J Physiol Lung Cell Mol Physiol
6889242Contraception today. (1983 May)Rowlands SPractitioner
10867693Dynamic echo planar MR imaging of lung ventilation with hyperpolarized (3)He in normal subjects and patients with severe emphysema. (2000 Jun)Gierada DSNMR Biomed
25929709Orthodontic forces add to nicotine-induced loss of periodontal bone : An in vivo and in vitro study. (2015 May)Kirschneck CJ Orofac Orthop
25469260Association of a transcription factor 21 gene polymorphism with hypertension. (2015 Jan)Fujimaki TBiomed Rep