Gene: NIPA2

81614
SLC57A2
NIPA magnesium transporter 2
protein-coding
15q11.2
Ensembl:ENSG00000140157 MIM:608146 Vega:OTTHUMG00000129101 UniprotKB:Q8N8Q9
NG_021303.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.930e-1 (AD)  1.568e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3764213chr15:22845401 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TIPRL0.926
YIPF50.925
FBXO110.924
UBQLN10.922
M6PR0.922
UBR10.919
POLR2B0.919
KLHL120.919
TNPO30.918
RNF1110.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
OR4F29-0.489
TNFRSF13B-0.366
CTNNA3-0.346
MTRNR2L6-0.324
HEY2-0.324
KLRK1-0.32
CSAG1-0.317
SH2D1A-0.314
MTRNR2L10-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of NIPA2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NIPA2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NIPA2 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of NIPA2 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of NIPA2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NIPA2 mRNA28196854
C006780bisphenol Abisphenol A results in increased expression of NIPA2 mRNA25181051
D003976DiazinonDiazinon results in increased methylation of NIPA2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NIPA2 mRNA21266533
D004147DioxinsDioxins affects the expression of NIPA2 mRNA20463971
D005839GentamicinsGentamicins results in increased expression of NIPA2 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of NIPA2 mRNA26846883
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NIPA2 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NIPA2 mRNA"25554681
C006253pirinixic acidpirinixic acid results in increased expression of NIPA2 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of NIPA2 mRNA23557933
C009277sodium arsenatesodium arsenate results in increased expression of NIPA2 mRNA23922661
D014635Valproic AcidValproic Acid affects the expression of NIPA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NIPA2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of NIPA2 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015095magnesium ion transmembrane transporter activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015693magnesium ion transport-IBA21873635  
GO:1903830magnesium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-5223345Miscellaneous transport and binding eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal