Gene: VMP1

81671
EPG3|TANGO5|TMEM49
vacuole membrane protein 1
protein-coding
17q23.1
Ensembl:ENSG00000062716 MIM:611753 Vega:OTTHUMG00000179882 UniprotKB:Q96GC9
NG_051107.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.934e-1 (AD)  2.035e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAUS20.916
ABCE10.912
YME1L10.911
DAP30.91
C5orf150.91
CDC420.908
ADPGK0.907
ACTR30.907
ECD0.905
HEXB0.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.58
EYA2-0.266
SALL3-0.262
FAM151A-0.254
ADAMTSL5-0.247
NXNL1-0.243
NWD1-0.242
FOXJ1-0.239
DIAPH3-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of VMP1 mRNA"16269432
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of VMP1 mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of VMP1 mRNA"23829299
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of VMP1 mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of VMP1 mRNA"23829299
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of VMP1 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VMP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VMP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of VMP1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of VMP1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of VMP1 mRNA21641981
C412373AG 1879AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of VMP1 mRNA23052036
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VMP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of VMP1 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of VMP1 mRNA22323515
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of VMP1 mRNA17690111
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of VMP1 mRNA16269432
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of VMP1 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VMP1 mRNA16269432|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VMP1 mRNA"20018196
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of VMP1 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of VMP1 mRNA24758408
C006780bisphenol Abisphenol A affects the expression of VMP1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of VMP1 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VMP1 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of VMP1 mRNA21595052
D019327Copper SulfateCopper Sulfate results in increased expression of VMP1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of VMP1 mRNA25562108
D003609Dactinomycin[Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA23052036
D003609DactinomycinDactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D003609Dactinomycin"Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of VMP1 mRNA]"23052036
D003609DactinomycinDactinomycin results in decreased expression of VMP1 mRNA23052036
D003634DDTDDT results in increased expression of VMP1 mRNA25014179
D003687Dehydroepiandrosterone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D003687DehydroepiandrosteroneAG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D003687DehydroepiandrosteroneDactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of VMP1 mRNA25969534
D003687Dehydroepiandrosteronemethyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D003687DehydroepiandrosteronePertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of VMP1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of VMP1 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of VMP1 mRNA28302478
D004147DioxinsDioxins affects the expression of VMP1 mRNA20463971
C504383fenbuconazolefenbuconazole results in increased expression of VMP1 mRNA15942997
C108339fludioxonil[Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA23052036
C007738fluoranthenefluoranthene results in increased expression of VMP1 mRNA16269432
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VMP1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of VMP1 mRNA27664576
C001277geldanamycingeldanamycin results in increased expression of VMP1 mRNA26705709
C056507gemcitabinegemcitabine results in increased expression of VMP120299819
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of VMP1 mRNA19376150
D007213IndomethacinIndomethacin results in increased expression of VMP1 mRNA16984733
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VMP1 mRNA25613284
C410337K 7174K 7174 results in increased expression of VMP1 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of VMP1 mRNA24967691
C045463leflunomideleflunomide results in increased expression of VMP1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of VMP1 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of VMP1 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VMP1 gene20938992
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of VMP1 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of VMP1 mRNA16026605
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of VMP1 mRNA]"23052036
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of VMP1 mRNA"23052036
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of VMP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of VMP1 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of VMP1 mRNA19812364
D009532NickelNickel results in increased expression of VMP1 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of VMP1 mRNA26378417
C025256nonylphenolnonylphenol results in increased expression of VMP1 mRNA22982499
C558013NSC 689534NSC 689534 results in increased expression of VMP1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of VMP1 mRNA25729387
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]25969534
D010634PhenobarbitalPhenobarbital results in increased expression of VMP1 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of VMP1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of VMP1 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of VMP1 mRNA16293270
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of VMP1 mRNA28903501
C045950propiconazolepropiconazole results in increased expression of VMP1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of VMP1 mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of VMP1 mRNA20436886
C016104sodium bichromatesodium bichromate results in increased expression of VMP1 mRNA22561333
D053260SootSoot results in increased expression of VMP1 mRNA22461453
C025462sulindac sulfidesulindac sulfide results in increased expression of VMP1 mRNA12734198
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of VMP1 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VMP1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VMP1 mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VMP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of VMP1 mRNA16054898
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VMP1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of VMP1 mRNA23557971|2776080
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of VMP1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of VMP1 mRNA20530235
C012589trichostatin Atrichostatin A affects the expression of VMP1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of VMP1 mRNA26705709
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of VMP1 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VMP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of VMP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of VMP1 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in increased methylation of VMP1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of VMP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17724469  19056683  23316280  
GO ID GO Term Qualifier Evidence PubMed
GO:0006887exocytosis-IBA21873635  
GO:0006914autophagy-IEA-  
GO:0007029endoplasmic reticulum organization-IBA21873635  
GO:0007030Golgi organization-IBA21873635  
GO:0007566embryo implantation-IEA-  
GO:0016236macroautophagy-IBA21873635  
GO:0034329cell junction assembly-IMP17724469  
GO:0098609cell-cell adhesion-IMP17724469  
GO ID GO Term Qualifier Evidence PubMed
GO:0000407phagophore assembly site-IBA21873635  
GO:0000421autophagosome membrane-ISS-  
GO:0005730nucleolus-IDA-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA17724469  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28766461Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes. (2017 Aug 1)Ruhrmann SMult Scler
27539333[Association between genetic variants in p53 binding sites and risks of breast cancer in Chinese population]. (2016 Aug 10)Chen WZhonghua Liu Xing Bing Xue Za Zhi