Gene: CAMK2D

817
CAMKD
calcium/calmodulin dependent protein kinase II delta
protein-coding
4q26
Ensembl:ENSG00000145349 MIM:607708 Vega:OTTHUMG00000132910 UniprotKB:Q13557
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.559e-1 (AD)  2.881e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6533710chr4:113668110 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRAS0.931
ARMC80.931
FEM1B0.931
CDC270.929
STAM0.929
DYNC1LI10.929
ACSL40.928
SLC9B20.925
JAZF10.925
SLC25A460.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.49
OR4F29-0.451
ASB4-0.441
ACOX2-0.431
MYOM1-0.425
RHOD-0.409
EYA2-0.402
C22orf31-0.389
OLAH-0.386
HEY2-0.386

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB07853[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILESmall MoleculeExperimentalTarget
DB08039(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of CAMK2D mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of CAMK2D protein"24680724
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CAMK2D mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CAMK2D mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CAMK2D mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of CAMK2D mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CAMK2D gene27153756
C430898AGN 194204AGN 194204 results in increased expression of CAMK2D mRNA16339527
D000393Air PollutantsAir Pollutants analog results in decreased expression of CAMK2D mRNA21757418
D003913DextroamphetamineDextroamphetamine affects the expression of CAMK2D mRNA12558987
C006632arsenic trioxidearsenic trioxide results in decreased expression of CAMK2D mRNA24831965
D016589AstemizoleAstemizole results in decreased expression of CAMK2D mRNA20221588
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CAMK2D mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CAMK2D mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CAMK2D mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CAMK2D mRNA20660070
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CAMK2D mRNA26496021
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CAMK2D mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CAMK2D mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CAMK2D mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CAMK2D mRNA24066056
C018475butyraldehydebutyraldehyde results in decreased expression of CAMK2D mRNA26079696
D002087ButyratesButyrates results in decreased expression of CAMK2D mRNA14674679
D002104CadmiumCadmium affects the localization of CAMK2D protein22553113
D002104CadmiumKN 93 inhibits the reaction [Cadmium affects the localization of CAMK2D protein]22553113
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CAMK2D mRNA20360939
D002118CalciumCalcium affects the expression of CAMK2D mRNA15913539
D002220CarbamazepineCarbamazepine affects the expression of CAMK2D mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CAMK2D mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CAMK2D mRNA20938992
D003024ClozapineClozapine results in decreased expression of CAMK2D mRNA15860345
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CAMK2D mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of CAMK2D mRNA19167446
D003471CuprizoneCuprizone results in increased expression of CAMK2D mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CAMK2D mRNA19770486
D003703DemecolcineDemecolcine results in decreased expression of CAMK2D mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CAMK2D mRNA28628672
D003976DiazinonDiazinon affects the expression of CAMK2D mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CAMK2D mRNA27392435
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CAMK2D mRNA23625948
D002945CisplatinCisplatin results in decreased expression of CAMK2D mRNA22023808
D019422Dietary SucroseDietary Sucrose results in increased expression of CAMK2D mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CAMK2D mRNA20360939
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CAMK2D mRNA25380136
D004237DiuronDiuron results in decreased expression of CAMK2D mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CAMK2D protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CAMK2D mRNA22079256
D000431EthanolEthanol results in increased expression of CAMK2D mRNA20655511
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CAMK2D mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CAMK2D mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CAMK2D mRNA23649840
C039281furanfuran results in increased expression of CAMK2D mRNA27387713
D019833GenisteinGenistein results in increased expression of CAMK2D mRNA21782745
D005839GentamicinsGentamicins results in increased expression of CAMK2D mRNA22061828
C401311GW 7845GW 7845 results in increased activity of CAMK2D protein20810541
D006220HaloperidolHaloperidol results in decreased expression of CAMK2D mRNA15860345
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of CAMK2D protein24680724
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CAMK2D mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAMK2D mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CAMK2D mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CAMK2D mRNA27392435
C072105KN 93KN 93 inhibits the reaction [Cadmium affects the localization of CAMK2D protein]22553113
D007854LeadLead affects the expression of CAMK2D mRNA28903495
D007854LeadLead affects the splicing of CAMK2D mRNA28903495
C008261lead acetatelead acetate results in decreased expression of CAMK2D mRNA22641619
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CAMK2D mRNA21641980
C042720mercuric bromidemercuric bromide results in increased expression of CAMK2D mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CAMK2D mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of CAMK2D mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CAMK2D mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CAMK2D mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CAMK2D mRNA"19285098
D008777MethyltestosteroneMethyltestosterone results in decreased expression of CAMK2D mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CAMK2D mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CAMK2D mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CAMK2D mRNA25380136
C022838nickel chloridenickel chloride affects the expression of CAMK2D mRNA22546817
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CAMK2D mRNA25729387
D010656PhenylephrineCAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]15629441
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAMK2D mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CAMK2D mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CAMK2D mRNA18301758|1844570
C006253pirinixic acidpirinixic acid results in increased expression of CAMK2D mRNA12832660
D010936Plant ExtractsPlant Extracts results in increased expression of CAMK2D mRNA23557933
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased expression of SYN1 mRNA]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased phosphorylation of MAPK1 protein]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased phosphorylation of MAPK3 protein]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]18004999
D011189Potassium ChlorideCAMK2D protein affects the reaction [Potassium Chloride results in increased phosphorylation of SRC protein]18004999
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CAMK2D mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CAMK2D mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CAMK2D mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of CAMK2D mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CAMK2D mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of CAMK2D mRNA21795629
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of CAMK2D mRNA16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CAMK2D mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAMK2D mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAMK2D protein24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CAMK2D mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CAMK2D mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAMK2D mRNA25613284
D013806TheophyllineTheophylline results in decreased expression of CAMK2D mRNA18951874
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CAMK2D mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CAMK2D mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of CAMK2D mRNA23228038
D014212TretinoinTretinoin results in increased expression of CAMK2D mRNA23724009|2383079
C011559tributyltintributyltin results in increased activity of CAMK2D protein20810541
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CAMK2D mRNA"26179874
D014501UraniumUranium affects the expression of CAMK2D mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of CAMK2D mRNA15672453
D014635Valproic AcidValproic Acid results in increased expression of CAMK2D protein17675408
D014638VanadatesVanadates results in increased expression of CAMK2D mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CAMK2D gene25560391
C025643vinclozolinvinclozolin affects the expression of CAMK2D mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of CAMK2D mRNA20566332
D014750VincristineVincristine results in decreased expression of CAMK2D mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of CAMK2D mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of CAMK2D mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IDA22514276  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004683calmodulin-dependent protein kinase activity-IBA21873635  
GO:0004683calmodulin-dependent protein kinase activity-IDA22514276  23283722  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI17353931  20668654  22514276  25416956  25852190  29426014  
GO:0005516calmodulin binding-IBA21873635  
GO:0005516calmodulin binding-IPI20668654  
GO:0005524ATP binding-IEA-  
GO:0019871sodium channel inhibitor activity-IDA22514276  
GO:0031432titin binding-IPI23283722  
GO:0042802identical protein binding-IPI20668654  25416956  
GO:0042803protein homodimerization activity-IPI20668654  
GO:0044325ion channel binding-IPI22514276  
GO:0044325ion channel binding-ISS12676814  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001558regulation of cell growth-NAS9060999  
GO:0002026regulation of the force of heart contraction-TAS23283722  
GO:0003254regulation of membrane depolarization-IDA22514276  
GO:0006357regulation of transcription by RNA polymerase II-TAS23283722  
GO:0006468protein phosphorylation-IDA17179159  23283722  
GO:0008016regulation of heart contraction-TAS17157285  
GO:0010613positive regulation of cardiac muscle hypertrophy-IMP17179159  
GO:0010649regulation of cell communication by electrical coupling-ISS-  
GO:0010666positive regulation of cardiac muscle cell apoptotic process-ISS-  
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-ISS-  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-IC12676813  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-TAS17157285  
GO:0018105peptidyl-serine phosphorylation-IDA22514276  23283722  
GO:0018107peptidyl-threonine phosphorylation-IDA22514276  23283722  
GO:0032469endoplasmic reticulum calcium ion homeostasis-ISS-  
GO:0046777protein autophosphorylation-IDA22514276  
GO:0051259protein complex oligomerization-IDA20668654  
GO:0055119relaxation of cardiac muscle-ISS12676814  
GO:0060314regulation of ryanodine-sensitive calcium-release channel activity-TAS12676813  19482609  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060341regulation of cellular localization-IMP17179159  
GO:0071277cellular response to calcium ion-TAS23283722  
GO:0086003cardiac muscle cell contraction-ISS12676814  
GO:0086091regulation of heart rate by cardiac conduction-IC22514276  
GO:0098901regulation of cardiac muscle cell action potential-ISS-  
GO:0098909regulation of cardiac muscle cell action potential involved in regulation of contraction-IC12676813  
GO:1901725regulation of histone deacetylase activity-TAS23283722  
GO:1901844regulation of cell communication by electrical coupling involved in cardiac conduction-IC12676813  
GO:1901897regulation of relaxation of cardiac muscle-IDA23283722  
GO:1902306negative regulation of sodium ion transmembrane transport-IDA22514276  
GO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channel-ISS-  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IDA22514276  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS12676814  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS12676814  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0033017sarcoplasmic reticulum membrane-IEA-  
GO:0042383sarcolemma-IEA-  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04114Oocyte meiosis
hsa04310Wnt signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04740Olfactory transduction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04971Gastric acid secretion
hsa05214Glioma
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-438066Unblocking of NMDA receptor, glutamate binding and activationTAS
R-HSA-442729CREB phosphorylation through the activation of CaMKIITAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-442982Ras activation upon Ca2+ influx through NMDA receptorTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal