Gene: SLC14A2

8170
HUT2|UT-A2|UT2|UTA|UTR|hUT-A6
solute carrier family 14 member 2
protein-coding
18q12.3
Ensembl:ENSG00000132874 MIM:601611 Vega:OTTHUMG00000132616 UniprotKB:Q15849
NC_000018.10
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.134e-1 (AD)  2.020e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7243707chr18:45652309 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs8099273chr18:45524247 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs8099211chr18:45523993 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1A20.603
PMM20.601
TNFRSF11A0.561
FSIP10.539
ZNF7780.539
ENTPD70.535
DNAH50.533
MTHFD1L0.53
ZNF6970.528
ARSB0.527

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAIP2B-0.326
BCAS1-0.317
FXYD3-0.315
NPIPB6-0.301
LPAR1-0.3
CTNNA3-0.292
NRN1L-0.29
HBA2-0.29
KIF1C-0.29
ROM1-0.287

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03904UreaSmall Molecule57-13-6Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC14A2 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SLC14A2 mRNA"27291303
C4687863-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one inhibits the reaction [SB 657510 inhibits the reaction [Acetaminophen results in increased expression of SLC14A2 mRNA]]26176337
D000082Acetaminophen3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one inhibits the reaction [SB 657510 inhibits the reaction [Acetaminophen results in increased expression of SLC14A2 mRNA]]26176337
D000082AcetaminophenAcetaminophen affects the expression of SLC14A2 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of SLC14A2 mRNA26176337
D000082AcetaminophenSB 657510 inhibits the reaction [Acetaminophen results in increased expression of SLC14A2 mRNA]26176337
D000111AcetylcysteineAcetylcysteine results in increased expression of SLC14A2 protein23183129
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC14A2 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC14A2 gene27153756
D000499AllylamineAllylamine affects the expression of SLC14A2 mRNA15910882
D000638AmiodaroneAmiodarone results in increased expression of SLC14A2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC14A2 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of SLC14A2 mRNA15761015
D001280AtrazineAtrazine results in increased expression of SLC14A2 mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of SLC14A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC14A2 gene28505145
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC14A2 mRNA20360939
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC14A2 mRNA16644059
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SLC14A2 mRNA18636392
D060729Coal AshCoal Ash results in decreased expression of SLC14A2 mRNA19000753
D003042CocaineCocaine affects the expression of SLC14A2 mRNA20187946
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SLC14A2 mRNA23640034
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC14A2 mRNA20360939
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC14A2 mRNA22129741
D004317DoxorubicinDoxorubicin results in decreased expression of SLC14A2 protein9573539
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC14A2 mRNA17555576
D005419FlavonoidsFlavonoids results in increased expression of SLC14A2 mRNA18035473
D017313FenretinideFenretinide results in increased expression of SLC14A2 mRNA28973697
D006918HydroxyureaSLC14A2 protein results in increased uptake of Hydroxyurea21256917
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC14A2 mRNA22129741
D007657Ketone BodiesKetone Bodies results in decreased expression of SLC14A2 mRNA16807920
D008094LithiumLithium results in decreased expression of SLC14A2 protein25006961
D008094LithiumPRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of SLC14A2 protein]25006961
D008694MethamphetamineMethamphetamine results in decreased expression of SLC14A2 mRNA26307267
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SLC14A2 protein"21135415
D009638NorepinephrineNorepinephrine results in decreased expression of SLC14A2 protein16788141
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SLC14A2 mRNA18636392
D010416PentachlorophenolPentachlorophenol results in decreased expression of SLC14A2 mRNA24642059
D010693PhloretinPhloretin inhibits the reaction [SLC14A2 protein results in increased transport of Urea]9019665
D010693PhloretinPhloretin inhibits the reaction [SLC14A2 protein results in increased transport of Urea]11181411
C006253pirinixic acidpirinixic acid results in increased expression of SLC14A2 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC14A2 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC14A2 mRNA24780913
C553589SB 6575103-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one inhibits the reaction [SB 657510 inhibits the reaction [Acetaminophen results in increased expression of SLC14A2 mRNA]]26176337
C553589SB 657510SB 657510 inhibits the reaction [Acetaminophen results in increased expression of SLC14A2 mRNA]26176337
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC14A2 mRNA25895662
D012834SilverSilver results in increased expression of SLC14A2 mRNA27131904
D013629TamoxifenTamoxifen affects the expression of SLC14A2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC14A2 mRNA22298810
D013890ThioureaThiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea]11181411
C009495titanium dioxidetitanium dioxide results in decreased expression of SLC14A2 mRNA23557971
D014050TolueneToluene affects the expression of SLC14A2 mRNA18653662
D014508UreaPhloretin inhibits the reaction [SLC14A2 protein results in increased transport of Urea]9019665
D014508UreaSLC14A2 protein results in increased transport of Urea9019665
D014508UreaSLC14A2 protein results in increased uptake of Urea16380458
D014508UreaPhloretin inhibits the reaction [SLC14A2 protein results in increased transport of Urea]11181411
D014508UreaSLC14A2 protein results in increased transport of Urea11181411
D014508UreaThiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea]11181411
D014635Valproic AcidValproic Acid results in increased methylation of SLC14A2 gene29154799
D014639VanadiumVanadium results in increased expression of SLC14A2 mRNA19000753
D014640VancomycinVancomycin results in decreased expression of SLC14A2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC14A2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC14A2 mRNA26682919
D015032ZincZinc results in increased expression of SLC14A2 mRNA18316168

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015204urea transmembrane transporter activity-TAS-  
GO:0050839cell adhesion molecule binding-IDA23620790  
GO ID GO Term Qualifier Evidence PubMed
GO:0015840urea transport-TAS8647271  
GO:0055085transmembrane transport-TAS-  
GO:0071918urea transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-TAS8647271  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal