Gene: DOCK8

81704
HEL-205|MRD2|ZIR8
dedicator of cytokinesis 8
protein-coding
9p24.3
Ensembl:ENSG00000107099 MIM:611432 Vega:OTTHUMG00000078789 UniprotKB:Q8NF50
NG_017007.1
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.543e-1 (AD)  4.702e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12346176chr9:398673 (GRCh38.p7)A>C / A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12348944chr9:377066 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYK0.895
BTK0.886
NCKAP1L0.882
TLR60.871
IL180.87
APBB1IP0.869
PTPRC0.868
DOCK20.867
LPAR60.864
CD860.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.456
MAGIX-0.421
ASPDH-0.387
ZNF835-0.367
TMEM121-0.367
DLK2-0.363
KREMEN2-0.363
CHRNA4-0.363
KCNK4-0.362
HAGHL-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of DOCK8 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DOCK8 mRNA"22698814|2890350
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOCK8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOCK8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK8 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DOCK8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DOCK8 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of DOCK8 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DOCK8 mRNA24449571
C015001arsenitearsenite results in decreased methylation of DOCK8 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of DOCK8 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK8 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK8 mRNA19770486|2156981
D004958EstradiolEstradiol results in decreased expression of DOCK8 mRNA19167446
C006780bisphenol Abisphenol A affects the expression of DOCK8 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DOCK8 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of DOCK8 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DOCK8 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DOCK8 mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of DOCK8 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of DOCK8 mRNA19789285
D003375CoumestrolCoumestrol results in decreased expression of DOCK8 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of DOCK8 mRNA27523638
D003703DemecolcineDemecolcine results in decreased expression of DOCK8 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DOCK8 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of DOCK8 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DOCK8 mRNA27594783
D002945CisplatinCisplatin results in increased expression of DOCK8 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of DOCK8 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of DOCK8 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of DOCK8 mRNA21592394
D005485FlutamideFlutamide results in decreased expression of DOCK8 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DOCK8 mRNA20938992
C071834glycidamideglycidamide results in decreased expression of DOCK8 mRNA17822822
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DOCK8 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of DOCK8 mRNA27392435
C042720mercuric bromidemercuric bromide results in decreased expression of DOCK8 mRNA26272509
D008627Mercuric ChlorideMercuric Chloride affects the expression of DOCK8 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DOCK8 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DOCK8 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DOCK8 mRNA23179753|2627250
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DOCK8 mRNA26011545
C523799MRK 003MRK 003 results in decreased expression of DOCK8 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DOCK8 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DOCK8 mRNA"25620056
D009532NickelNickel results in decreased expression of DOCK8 mRNA23195993
D009532NickelNickel results in increased expression of DOCK8 mRNA24768652|2558310
C041747nitazoxanideDOCK8 gene SNP affects the susceptibility to nitazoxanide25622337
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of DOCK8 mRNA19074003
C016030pantogabpantogab results in decreased expression of DOCK8 mRNA17379144
D010634PhenobarbitalPhenobarbital affects the expression of DOCK8 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOCK8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DOCK8 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of DOCK8 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of DOCK8 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of DOCK8 mRNA24780913
C059514resveratrolresveratrol results in increased expression of DOCK8 mRNA23419489
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DOCK8 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of DOCK8 mRNA23221170
C009277sodium arsenatesodium arsenate results in increased expression of DOCK8 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of DOCK8 mRNA28595984
D012999SomanSoman results in increased expression of DOCK8 mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of DOCK8 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of DOCK8 mRNA21592394
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of DOCK8 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DOCK8 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DOCK8 mRNA25613284
D014212TretinoinTretinoin results in increased expression of DOCK8 mRNA23830798
C012589trichostatin Atrichostatin A results in decreased expression of DOCK8 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK8 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of DOCK8 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of DOCK8 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DOCK8 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DOCK8 gene25560391
D014750VincristineVincristine results in decreased expression of DOCK8 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of DOCK8 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IDA28028151  
GO:0005515protein binding-IPI22581261  25416956  26871637  28028151  
GO ID GO Term Qualifier Evidence PubMed
GO:0001771immunological synapse formation-IEA-  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0036336dendritic cell migration-IEA-  
GO:0043547positive regulation of GTPase activity-IDA28028151  
GO:0061485memory T cell proliferation-IMP22006977  
GO:0070233negative regulation of T cell apoptotic process-IEA-  
GO:1903905positive regulation of establishment of T cell polarity-IMP28028151  
GO:1990869cellular response to chemokine-IMP28028151  
GO:2000406positive regulation of T cell migration-IMP28028151  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA28028151  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0031256leading edge membrane-IDA28028151  
GO:0031258lamellipodium membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal