Gene: NUAK2

81788
SNARK
NUAK family kinase 2
protein-coding
1q32.1
Ensembl:ENSG00000163545 MIM:608131 Vega:OTTHUMG00000037196 UniprotKB:Q9H093
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.081e-1 (AD)  3.624e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFKB20.848
BAZ1A0.831
STAT5A0.813
TNFRSF10B0.81
CDK20.81
TIMP10.809
HMOX10.801
PPP1R180.799
PLAUR0.799
IL1R10.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.572
SLC7A4-0.561
SLC1A6-0.546
SLC32A1-0.539
GAD2-0.534
ABCC12-0.524
SMIM18-0.523
CHRNB2-0.522
MYOZ3-0.518
DLX1-0.516

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of NUAK2 mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NUAK2 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NUAK2 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NUAK2 mRNA"19114083
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of NUAK2 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of NUAK2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of NUAK2 mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NUAK2 mRNA22129741
D020106AcrylamideAcrylamide results in increased expression of NUAK2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NUAK2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NUAK2 mRNA21641981|2715375
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NUAK2 mRNA24449571
D001151ArsenicArsenic affects the expression of NUAK2 mRNA18414638
D001151ArsenicArsenic affects the methylation of NUAK2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of NUAK2 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NUAK2 mRNA"18687144
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NUAK2 mRNA18164116
C006780bisphenol Abisphenol A results in decreased expression of NUAK2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of NUAK2 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of NUAK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NUAK2 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of NUAK2 mRNA25979313
D002922CiguatoxinsCiguatoxins affects the expression of NUAK2 mRNA18353800
D019327Copper SulfateCopper Sulfate results in increased expression of NUAK2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of NUAK2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of NUAK2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of NUAK2 mRNA25562108
D003976DiazinonDiazinon affects the expression of NUAK2 mRNA22546817
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of NUAK2 mRNA28962523
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of NUAK2 mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of NUAK2 mRNA]27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of NUAK2 mRNA18164116
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NUAK2 mRNA22129741
C540355fenamidonefenamidone results in increased expression of NUAK2 mRNA27029645
D005485FlutamideFlutamide results in decreased expression of NUAK2 mRNA24136188
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of NUAK2 mRNA24657277
D005557FormaldehydeFormaldehyde results in decreased expression of NUAK2 mRNA20655997
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of NUAK2 mRNA22467014
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NUAK2 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUAK2 mRNA25613284
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of NUAK2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of NUAK2 mRNA]27392435
C008261lead acetatelead acetate results in increased expression of NUAK2 mRNA21829687
C045463leflunomideleflunomide results in increased expression of NUAK2 mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NUAK2 mRNA26378955
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of NUAK2 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of NUAK2 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NUAK2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NUAK2 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NUAK2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of NUAK2 mRNA25729387
C496932panobinostatpanobinostat results in decreased expression of NUAK2 mRNA26272509
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NUAK2 mRNA27153767
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUAK2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of NUAK2 mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NUAK2 mRNA22714537
D011205Povidone[Silver analog co-treated with Povidone] results in decreased expression of NUAK2 mRNA25194297
C045950propiconazolepropiconazole results in decreased expression of NUAK2 mRNA21278054
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NUAK2 mRNA27029645
C012526quercitrinquercitrin results in decreased expression of NUAK2 mRNA25193878
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of NUAK2 mRNA21427059
C010327salinomycinsalinomycin results in decreased expression of NUAK2 mRNA19682730
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NUAK2 mRNA23806026
D012834SilverSilver results in increased expression of NUAK2 mRNA26014281|2895954
D012834Silver[Silver analog co-treated with Povidone] results in decreased expression of NUAK2 mRNA25194297
D012999SomanSoman results in increased expression of NUAK2 mRNA19281266
D053260SootSoot results in increased expression of NUAK2 mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NUAK2 mRNA26378955
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of NUAK2 mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUAK2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of NUAK2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUAK2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUAK2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUAK2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of NUAK2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NUAK2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NUAK2 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of NUAK2 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NUAK2 mRNA"26743178
C057693troglitazonetroglitazone results in decreased expression of NUAK2 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of NUAK2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NUAK2 mRNA26272509|2915479
D014635Valproic AcidValproic Acid results in increased expression of NUAK2 mRNA21427059
D019287Zinc SulfateZinc Sulfate results in increased expression of NUAK2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA14976552  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA14976552  19927127  
GO:0004679AMP-activated protein kinase activity-IBA21873635  
GO:0005515protein binding-IPI19927127  
GO:0005524ATP binding-IDA14976552  
GO:0035174histone serine kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA14976552  
GO:0006915apoptotic process-IEA-  
GO:0030036actin cytoskeleton organization-IDA14575707  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0042149cellular response to glucose starvation-IDA14575707  
GO:0043066negative regulation of apoptotic process-IDA15345718  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27602492Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro. (2016 Nov 15)Goto KOncotarget