Gene: NETO1

81832
BCTL1|BTCL1
neuropilin and tolloid like 1
protein-coding
18q22.3
Ensembl:ENSG00000166342 MIM:607973 Vega:OTTHUMG00000132834 UniprotKB:Q8TDF5
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.007e-1 (AD)  9.181e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN2A0.947
CACNB40.947
GPR1580.946
GDA0.946
STXBP5L0.944
CREG20.942
NMNAT20.942
NRXN30.941
FRMPD40.941
PRKCE0.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.586
CSAG1-0.571
FLT3LG-0.564
EMP3-0.56
HEY2-0.559
SYDE1-0.557
RNF135-0.556
MYL3-0.551
TGIF1-0.546
ROM1-0.545

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased expression of NETO1 mRNA"25270620
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NETO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NETO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NETO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NETO1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NETO1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NETO1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NETO1 mRNA21298039
C015001arsenitearsenite results in increased methylation of NETO1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of NETO1 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of NETO1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of NETO1 exon26001963
D004958EstradiolEstradiol affects the expression of NETO1 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of NETO1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NETO1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NETO1 mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of NETO1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of NETO1 mRNA26577399
C014347decitabinedecitabine results in increased expression of NETO1 mRNA21856257
D002117CalcitriolCalcitriol results in decreased expression of NETO1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of NETO1 mRNA21592394
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of NETO1 mRNA"27840820
C540355fenamidonefenamidone results in decreased expression of NETO1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NETO1 mRNA20938992
D004397FonofosFonofos results in increased methylation of NETO1 promoter22847954
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NETO1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NETO1 mRNA28001369
D010278ParathionParathion results in increased methylation of NETO1 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of NETO1 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NETO1 mRNA"27188386
D011441PropylthiouracilPropylthiouracil results in increased expression of NETO1 mRNA24780913
D012834SilverSilver results in decreased expression of NETO1 mRNA26551752
C012568terbufosterbufos results in increased methylation of NETO1 promoter22847954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of NETO1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of NETO1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NETO1 mRNA24680724
D014212TretinoinTretinoin results in increased expression of NETO1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of NETO1 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NETO1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NETO1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NETO1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NETO1 gene25560391
C025643vinclozolinvinclozolin affects the expression of NETO1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0035255ionotropic glutamate receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007613memory-ISS-  
GO:0008542visual learning-ISS-  
GO:0048169regulation of long-term neuronal synaptic plasticity-ISS-  
GO:0097120receptor localization to synapse-IEA-  
GO:2000312regulation of kainate selective glutamate receptor activity-IDA26277340  
GO:2000463positive regulation of excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0014069postsynaptic density-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0060076excitatory synapse-ISS-  
GO:0098839postsynaptic density membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26174813New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. (2015 Sep)Alemany SAm J Med Genet B Neuropsychiatr Genet