Gene: SBF2

81846
CMT4B2|DENND7B|MTMR13
SET binding factor 2
protein-coding
11p15.4
Ensembl:ENSG00000133812 MIM:607697 Vega:OTTHUMG00000165890 UniprotKB:Q86WG5
NG_008074.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.068e-1 (AD)  5.645e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DENND4C0.877
KAT6A0.856
ZKSCAN80.848
SORBS10.847
EPB41L50.844
MTM10.84
RBL20.839
PKN20.839
FER0.838
QSER10.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.51
OR4F29-0.495
NPW-0.294
LCN1-0.292
CLPSL1-0.281
KCNG2-0.275
LRRC38-0.271
GSG1-0.266
SULT2B1-0.262
CRH-0.257

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SBF2 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SBF2 protein20106945
D001151ArsenicArsenic affects the methylation of SBF2 gene25304211
D001280AtrazineAtrazine results in decreased expression of SBF2 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SBF2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SBF2 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SBF2 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SBF2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of SBF2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SBF2 mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SBF2 mRNA26272509
D003471CuprizoneCuprizone results in decreased expression of SBF2 mRNA26577399|2752363
D003703DemecolcineDemecolcine results in increased expression of SBF2 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SBF2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SBF2 mRNA27594783
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SBF2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SBF2 mRNA19467301
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of SBF2 mRNA21852083
D004237DiuronDiuron results in increased expression of SBF2 mRNA25152437
C118739entinostatentinostat results in increased expression of SBF2 mRNA26272509
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SBF2 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of SBF2 mRNA23649840
D048628KetolidesKetolides analog results in increased expression of SBF2 mRNA24967691
C042720mercuric bromidemercuric bromide results in increased expression of SBF2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SBF2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SBF2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SBF2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SBF2 mRNA"26251327
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SBF2 mRNA"29244179
C496932panobinostatpanobinostat results in increased expression of SBF2 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SBF2 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SBF2 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of SBF2 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of SBF2 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of SBF2 mRNA24780913
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of SBF2 mRNA21852083
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SBF2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SBF2 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in decreased expression of SBF2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of SBF2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SBF2 mRNA23179753|2493525
D014750VincristineVincristine results in increased expression of SBF2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15998640  25416956  
GO:0017112Rab guanyl-nucleotide exchange factor activity-IDA20937701  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO:0019208phosphatase regulator activity-IEA-  
GO:0019902phosphatase binding-IEA-  
GO:0035091phosphatidylinositol binding-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0042552myelination-NAS15998640  
GO:0043087regulation of GTPase activity-IEA-  
GO:0051262protein tetramerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005774vacuolar membrane-IEA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IDA15998640  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-1483255PI MetabolismIEA
R-HSA-1483257Phospholipid metabolismIEA
R-HSA-1660499Synthesis of PIPs at the plasma membraneIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29552140Upregulated long non-coding RNA SBF2-AS1 promotes proliferation in esophageal squamous cell carcinoma. (2018 Apr)Chen ROncol Lett