Gene: RNF146

81847
-
ring finger protein 146
protein-coding
6q22.33
Ensembl:ENSG00000118518 MIM:612137 Vega:OTTHUMG00000015522 UniprotKB:Q9NTX7
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.411e-1 (AD)  3.423e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERINC10.938
FAM192A0.933
YWHAQ0.93
MATR30.926
TOP2B0.925
HNRNPDL0.923
PAPSS10.923
TMEM30A0.922
RNF140.919
UBE2G10.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.784
OR4F5-0.77
MTRNR2L10-0.264
MTRNR2L6-0.262
MTRNR2L9-0.252
C8orf74-0.244
MTRNR2L3-0.236
MTRNR2L8-0.231
MTRNR2L2-0.225
SIX1-0.222

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RNF146 mRNA"19114083
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RNF146 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RNF146 mRNA]28655636
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RNF146 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of RNF146 mRNA19774075
D001280AtrazineAtrazine results in increased expression of RNF146 mRNA25929836
C447119bazedoxifenebazedoxifene results in increased expression of RNF146 mRNA19914376
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RNF146 mRNA20498004
C006780bisphenol Abisphenol A results in increased expression of RNF146 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of RNF146 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RNF146 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of RNF146 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RNF146 mRNA21266533
D002945CisplatinCisplatin results in increased expression of RNF146 mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of RNF146 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RNF146 mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RNF146 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNF146 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of RNF146 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RNF146 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RNF146 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of RNF146 mRNA20655997
D005897GlafenineGlafenine results in decreased expression of RNF146 mRNA24136188
C016517indole-3-carbinolindole-3-carbinol affects the expression of RNF146 mRNA21396975
C410337K 7174K 7174 results in increased expression of RNF146 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of RNF146 mRNA16807920
D007854LeadLead affects the splicing of RNF146 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RNF146 gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of RNF146 mRNA21061450
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of RNF146 mRNA20020106
D015735MifepristoneMifepristone results in increased expression of RNF146 mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RNF146 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RNF146 mRNA"25554681
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RNF146 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of RNF146 mRNA28655636
D010416PentachlorophenolPentachlorophenol results in increased expression of RNF146 mRNA24642059
C046012pentanalpentanal results in decreased expression of RNF146 mRNA26079696
D010795Phthalic AcidsPhthalic Acids results in increased expression of RNF146 mRNA21061450
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of RNF146 mRNA20020106
D011441PropylthiouracilPropylthiouracil results in decreased expression of RNF146 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of RNF146 mRNA21632981
D012834SilverSilver results in decreased expression of RNF146 mRNA27131904
D013629TamoxifenTamoxifen affects the expression of RNF146 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RNF146 mRNA17942748
D014635Valproic AcidValproic Acid affects the expression of RNF146 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RNF146 mRNA23179753|2519280
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RNF146 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of RNF146 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RNF146 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of RNF146 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA21478859  
GO:0005515protein binding-IPI21478859  25327252  25416956  
GO:0008270zinc ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO:0072572poly-ADP-D-ribose binding-IDA21478859  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IMP21478859  
GO:0016055Wnt signaling pathway-IEA-  
GO:0051865protein autoubiquitination-IDA21478859  
GO:0070936protein K48-linked ubiquitination-IMP21478859  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP21478859  
GO:0090263positive regulation of canonical Wnt signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA15813938  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21791674Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. (2011 Aug 17)Campa DJ Natl Cancer Inst