Gene: MIA

8190
CD-RAP
MIA SH3 domain containing
protein-coding
19q13.2
Ensembl:ENSG00000261857 MIM:601340 Vega:OTTHUMG00000182693 UniprotKB:Q16674
NC_000019.10
PubMed
0   ANCO-SNPs
ND|AD
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.480e-2 (AD)  8.351e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C7orf610.813
CCNA20.765
SLFNL10.765
TLR90.727
BNIPL0.722
NPIPB60.695
SLC7A90.671
JMJD60.663
CLDN90.643
KLK140.64

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM3-0.521
PRSS27-0.517
ZSCAN1-0.468
SPDEF-0.459
NUDT18-0.451
MPO-0.449
CCT6B-0.449
HMGB3-0.448
ZNF449-0.441
SLC35G1-0.439

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MIA mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MIA mRNA16483693
D001151ArsenicArsenic affects the methylation of MIA gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of MIA mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MIA mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MIA mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of MIA mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MIA mRNA18180321
C006780bisphenol Abisphenol A results in increased methylation of MIA gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MIA mRNA14729362
C018475butyraldehydebutyraldehyde results in increased expression of MIA mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of MIA mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIA mRNA20938992
C031180chrysenechrysene results in decreased expression of MIA mRNA26377693
D002994ClofibrateClofibrate results in decreased expression of MIA mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of MIA mRNA24386269
D003042CocaineCocaine results in increased expression of MIA mRNA27899881
D003471CuprizoneCuprizone results in increased expression of MIA mRNA26577399|2752363
C014347decitabinedecitabine results in increased expression of MIA mRNA16367923
D002945CisplatinCisplatin results in decreased expression of MIA mRNA27392435
C118739entinostatentinostat results in increased expression of MIA mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIA mRNA20938992
C039281furanfuran results in increased expression of MIA mRNA25539665|2738771
D017313FenretinideFenretinide results in increased expression of MIA mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MIA mRNA25613284
D008345ManganeseManganese results in increased expression of MIA mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of MIA mRNA17175027
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIA mRNA20938992
C523799MRK 003MIA results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MIA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MIA mRNA"25554681
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MIA mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of MIA mRNA26705709
C006253pirinixic acidpirinixic acid results in decreased expression of MIA mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of MIA mRNA12832660
D010936Plant ExtractsPlant Extracts results in decreased expression of MIA mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of MIA mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of MIA mRNA26079696
C059514resveratrolresveratrol results in decreased expression of MIA mRNA23224687
D053260SootSoot results in increased expression of MIA mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MIA mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MIA mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of MIA mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MIA mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MIA mRNA20133372
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MIA mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of MIA mRNA24383497|2627250
D014810Vitamin EVitamin E results in increased expression of MIA mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MIA mRNA"27188386
C111237vorinostatvorinostat results in increased expression of MIA mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008283cell proliferation-TAS7923218  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS7923218  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20424515beta2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFkappaB and AP-1. (2010 Jul 1)Zhang DCancer Biol Ther
28964721Malnutrition, inflamation and atherosclerosis (MIA syndrome) in patients with end stage renal disease on maintenance hemodialysis (a single centre experience). (2018 Apr - Jun)Allawi AADDiabetes Metab Syndr
22080838A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (2012 Feb 15)Cho MHHum Mol Genet
17952355[Chronic renal disease, inflammation and atherosclerosis: new concepts about an old problem]. (2007 Sep-Oct)Dummer CDRev Assoc Med Bras (1992)
29228652Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung. (2017 Nov 17)Yu ROncotarget
25361983Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth. (2015 Jan)Kobayashi YAnn Oncol
28430580Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma. (2017 Jun 6)Cai LOncotarget
8693620[Mortality and fatal risk factors in 1075 outpatients treated for asthma]. (1996 Jun 17)Ulrik CSUgeskr Laeger
7606941Mortality and markers of risk of asthma death among 1,075 outpatients with asthma. (1995 Jul)Ulrik CSChest
27393502Air bronchogram: A potential indicator of epidermal growth factor receptor mutation in pulmonary subsolid nodules. (2016 Aug)Dai JLung Cancer