Gene: CLPP

8192
DFNB81|PRLTS3
caseinolytic mitochondrial matrix peptidase proteolytic subunit
protein-coding
19p13.3
Ensembl:ENSG00000125656 MIM:601119 Vega:OTTHUMG00000180779 UniprotKB:Q16740
NG_033887.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.053e-1 (AD)  3.613e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1470.929
JTB0.909
TUFM0.908
LMAN20.908
NTMT10.907
AURKAIP10.905
EMC60.905
PSMA70.903
THAP40.902
MRPS240.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.778
OR4F29-0.745
P2RY14-0.293
FMO3-0.259
MTRNR2L6-0.252
MTRNR2L9-0.244
FCRL1-0.24
KRT73-0.239
TTLL10-AS1-0.235
PZP-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of CLPP protein23001822
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CLPP mRNA"21394737
D000082AcetaminophenAcetaminophen results in decreased expression of CLPP mRNA25704631
D000638AmiodaroneAmiodarone affects the expression of CLPP mRNA19483382
D001151ArsenicArsenic affects the methylation of CLPP gene25304211
D001553BenzbromaroneBenzbromarone affects the expression of CLPP mRNA19483382
C006780bisphenol Abisphenol A affects the expression of CLPP mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CLPP mRNA25181051
D002994ClofibrateClofibrate affects the expression of CLPP mRNA19483382
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CLPP mRNA]27941970
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of CLPP mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CLPP mRNA21266533
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CLPP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLPP mRNA17942748
D005001EthionineEthionine affects the expression of CLPP mRNA19483382
D018120FinasterideFinasteride results in increased expression of CLPP mRNA24136188
D005485FlutamideFlutamide results in increased expression of CLPP mRNA24136188
D007213IndomethacinIndomethacin results in increased expression of CLPP mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CLPP mRNA23086925|2429786
C410337K 7174K 7174 results in decreased expression of CLPP mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of CLPP mRNA24967691
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CLPP mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CLPP protein26558463
C051752nefazodonenefazodone results in increased expression of CLPP mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of CLPP mRNA19167457
C012655nimesulidenimesulide results in increased expression of CLPP mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of CLPP mRNA19483382
D010416PentachlorophenolPentachlorophenol results in increased expression of CLPP mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CLPP protein26879310
C006253pirinixic acidpirinixic acid affects the expression of CLPP mRNA19483382
D011441PropylthiouracilPropylthiouracil affects the expression of CLPP mRNA19483382
C009277sodium arsenatesodium arsenate results in increased expression of CLPP mRNA23922661
C016104sodium bichromatesodium bichromate results in increased expression of CLPP mRNA22155349
D018038Sodium SeleniteSodium Selenite results in increased expression of CLPP mRNA18175754
D013311StreptozocinStreptozocin affects the expression of CLPP mRNA18583417
D013467SulindacSulindac results in increased expression of CLPP mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLPP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLPP mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CLPP mRNA28973375
D019284ThapsigarginThapsigargin results in increased expression of CLPP mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of CLPP mRNA19483382
C012589trichostatin Atrichostatin A affects the expression of CLPP mRNA28542535
C057693troglitazonetroglitazone results in increased expression of CLPP protein18495193
D014635Valproic AcidValproic Acid results in increased methylation of CLPP gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CLPP gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CLPP mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA11923310  
GO:0005515protein binding-IPI11923310  16115876  
GO:0008233peptidase activity-TAS8543061  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0051260protein homooligomerization-IEA-  
GO:0051603proteolysis involved in cellular protein catabolic process-IDA11923310  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-IDA10525407  
GO:0009368endopeptidase Clp complex-IDA11923310  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21888706Obesity and smoking: are they modulators of cough intravesical peak pressure in stress urinary incontinence? (2011 Jul-Aug)Fuganti PEInt Braz J Urol