Gene: CAMP

820
CAP-18|CAP18|CRAMP|FALL-39|FALL39|HSD26|LL37
cathelicidin antimicrobial peptide
protein-coding
3p21.31
Ensembl:ENSG00000164047 MIM:600474 Vega:OTTHUMG00000133526 UniprotKB:P49913
NC_000003.12
PubMed
CD|OD|ND|AD
180   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.344e-1 (AD)  3.306e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRG30.682
DEFA40.667
CTSG0.636
CEACAM80.628
LTF0.628
CRISP30.606
PGLYRP10.605
MSMB0.6
KLK20.593
DEFA30.591

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AFF3-0.299
SLC10A5-0.281
TRIM72-0.274
TUBA8-0.267
TRIP13-0.258
CEP72-0.254
SSTR3-0.253
ETNK1-0.252
TOM1L1-0.252
PDS5B-0.252

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02345SelenocysteineSmall Molecule10236-58-5ExperimentalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Calcitriol affects the localization of CAMP protein]"19748465
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CAMP mRNA]24039193
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of CAMP mRNA18544908
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Calcitriol affects the localization of CAMP protein]"19748465
D000082AcetaminophenAcetaminophen results in decreased expression of CAMP mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of CAMP mRNA18544908
D000447AldehydesAldehydes results in decreased expression of CAMP mRNA25014914
D000537Aluminum Oxide"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of CAMP protein"25598225
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CAMP mRNA24449571
D001151ArsenicArsenic affects the methylation of CAMP gene25304211
D001151ArsenicArsenic affects the expression of CAMP mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of CAMP mRNA19128835
C517975AZD 6244AZD 6244 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
C517975AZD 6244AZD 6244 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CAMP mRNA22316170
D004958EstradiolEstradiol results in decreased expression of CAMP mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of CAMP mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CAMP mRNA22659508
C018475butyraldehydebutyraldehyde results in decreased expression of CAMP mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CAMP promoter22457795
C055085calcipotrienecalcipotriene promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]24039193
C055085calcipotrienecalcipotriene promotes the reaction [resveratrol results in increased expression of CAMP mRNA]24039193
C026690cerous chloridecerous chloride results in increased expression of CAMP mRNA23573234
D003907Dexamethasone[Dexamethasone co-treated with Genistein] results in increased expression of CAMP mRNA25136773
D004008DiclofenacDiclofenac results in increased expression of CAMP mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of CAMP mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of CAMP mRNA]21852083
D002117Calcitriol"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Calcitriol affects the localization of CAMP protein]"19748465
D002117Calcitriol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
D002117Calcitriol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CAMP mRNA]24039193
D002117Calcitriol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
D002117Calcitriol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Calcitriol affects the localization of CAMP protein]"19748465
D002117CalcitriolAZD 6244 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
D002117CalcitriolAZD 6244 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
D002117CalcitriolCalcitriol affects the localization of CAMP protein19748465
D002117CalcitriolCalcitriol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]24039193
D002117CalcitriolCalcitriol promotes the reaction [pterostilbene results in increased expression of CAMP protein]24039193
D002117CalcitriolCalcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]24039193
D002117CalcitriolCalcitriol promotes the reaction [resveratrol results in increased expression of CAMP protein]24039193
D002117CalcitriolCalcitriol promotes the reaction [VDR protein binds to CAMP promoter]15985530
D002117CalcitriolCalcitriol results in increased expression of CAMP mRNA15985530|1818026
D002117CalcitriolCalcitriol results in increased expression of CAMP protein24039193
D002117CalcitriolCAMKK2 mutant form inhibits the reaction [Calcitriol affects the localization of CAMP protein]19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased activity of MAPK14 protein]19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased activity of MAPK1 protein]19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased activity of MAPK3 protein]19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK1] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK1] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK3] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK3] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]19748465
D002117CalcitriolCAMP results in increased susceptibility to Calcitriol19748465
D002117CalcitriolHR protein promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]22466564
D002117CalcitriolPRKAA1 mutant form inhibits the reaction [Calcitriol affects the localization of CAMP protein]19748465
D002117Calcitriolpterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]24039193
D002117Calcitriolpterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP protein]24039193
D002117Calcitriolresveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]24039193
D002117Calcitriolresveratrol promotes the reaction [Calcitriol results in increased expression of CAMP protein]24039193
D002117CalcitriolSB 203580 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
D002117CalcitriolSB 203580 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
D002117CalcitriolSTO 609 inhibits the reaction [Calcitriol affects the localization of CAMP protein]19748465
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMP mRNA17942748
D019833Genistein[Dexamethasone co-treated with Genistein] results in increased expression of CAMP mRNA25136773
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAMP mRNA25613284
D007530IsofluraneIsoflurane results in decreased expression of CAMP protein18382663
C074279KH 1060KH 1060 results in increased expression of CAMP mRNA15985530
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CAMP mRNA25613284
D008095Lithocholic AcidHR protein promotes the reaction [Lithocholic Acid results in increased expression of CAMP mRNA]22466564
D008095Lithocholic AcidLithocholic Acid analog results in increased expression of CAMP mRNA18180267
D008095Lithocholic Acid[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CAMP mRNA19733911
D008095Lithocholic AcidLithocholic Acid results in increased expression of CAMP mRNA19733911|2246656
D008095Lithocholic AcidLithocholic Acid results in increased expression of CAMP protein19733911
C502354lithocholic acid acetatelithocholic acid acetate results in increased expression of CAMP mRNA18180267
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of CAMP mRNA22563483
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA27460631
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CAMP mRNA"20188158
D015735MifepristoneMifepristone results in decreased expression of CAMP protein17701593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CAMP mRNA"25554681
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of CAMP protein"25598225
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CAMP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of CAMP protein"25598225
C031721naphthalenenaphthalene results in increased expression of CAMP mRNA18978301
D009538NicotineNicotine results in increased expression of CAMP mRNA23825647
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of CAMP mRNA22563483
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA27460631
C084656paricalcitolparicalcitol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]24039193
C084656paricalcitolparicalcitol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]24039193
C046012pentanalpentanal results in decreased expression of CAMP mRNA26079696
D011374ProgesteroneProgesterone results in increased expression of CAMP mRNA17701593
D011374ProgesteroneProgesterone results in increased expression of CAMP protein17701593
C005556propionaldehydepropionaldehyde results in decreased expression of CAMP mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CAMP mRNA24780913
C107773pterostilbenecalcipotriene promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]24039193
C107773pterostilbeneCalcitriol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]24039193
C107773pterostilbeneCalcitriol promotes the reaction [pterostilbene results in increased expression of CAMP protein]24039193
C107773pterostilbeneparicalcitol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]24039193
C107773pterostilbenepterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]24039193
C107773pterostilbenepterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP protein]24039193
C107773pterostilbenepterostilbene results in increased expression of CAMP mRNA24039193
C107773pterostilbenepterostilbene results in increased expression of CAMP protein24039193
C428725pyridabenpyridaben results in increased expression of CAMP mRNA22563483
C059514resveratrol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
C059514resveratrol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
C059514resveratrolAZD 6244 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
C059514resveratrolAZD 6244 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
C059514resveratrolcalcipotriene promotes the reaction [resveratrol results in increased expression of CAMP mRNA]24039193
C059514resveratrolCalcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]24039193
C059514resveratrolCalcitriol promotes the reaction [resveratrol results in increased expression of CAMP protein]24039193
C059514resveratrolparicalcitol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]24039193
C059514resveratrolresveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]24039193
C059514resveratrolresveratrol promotes the reaction [Calcitriol results in increased expression of CAMP protein]24039193
C059514resveratrolresveratrol results in increased expression of CAMP mRNA24039193
C059514resveratrolresveratrol results in increased expression of CAMP protein24039193
C059514resveratrolSB 203580 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
C059514resveratrolSB 203580 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of CAMP mRNA]21852083
C093642SB 203580SB 203580 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]24039193
C093642SB 203580SB 203580 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]24039193
C078903seocalcitolseocalcitol results in increased expression of CAMP mRNA15985530
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CAMP mRNA23806026
D018038Sodium SeleniteSodium Selenite results in increased expression of CAMP mRNA18175754
C458525STO 609STO 609 inhibits the reaction [Calcitriol affects the localization of CAMP protein]19748465
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAMP mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMP mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAMP mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CAMP mRNA"24407104
D014635Valproic AcidValproic Acid results in increased methylation of CAMP gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CAMP gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002227innate immune response in mucosa-IDA12860195  
GO:0019730antimicrobial humoral response-TAS-  
GO:0019731antibacterial humoral response-IDA12860195  
GO:0042742defense response to bacterium-IMP21115716  
GO:0043312neutrophil degranulation-TAS-  
GO:0044140negative regulation of growth of symbiont on or near host surface-IDA16177355  
GO:0045087innate immune response-IBA21873635  
GO:0050829defense response to Gram-negative bacterium-IBA21873635  
GO:0050830defense response to Gram-positive bacterium-IBA21873635  
GO:0050830defense response to Gram-positive bacterium-IDA12860195  
GO:0051873killing by host of symbiont cells-IDA16177355  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IBA21873635  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA12860195  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA12759353  12860195  18714013  21115716  
GO:0035580specific granule lumen-TAS-  
GO:0042581specific granule-IBA21873635  
GO:0042581specific granule-IDA12759353  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
hsa04970Salivary secretion
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20203187micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. (2010 Mar 3)Madhavan AJ Neurosci
11331423Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain. (2001 May)Pandey SCJ Neurochem
20424515beta2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFkappaB and AP-1. (2010 Jul 1)Zhang DCancer Biol Ther
28260499Regulatory role of G protein-coupled receptors in pancreatic cancer development and progression. (2017 Mar 3)Schuller HMCurr Med Chem
15196729Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. (2004 Jul)Schuller HMLung Cancer
15665076Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. (2005 Feb 1)Takahashi SProc Natl Acad Sci U S A
15198681Long-term regulation of signalling components of adenylyl cyclase and mitogen-activated protein kinase in the pre-frontal cortex of human opiate addicts. (2004 Jul)Ferrer-Alcon MJ Neurochem
28818835Src-dependent phosphorylation of mu-opioid receptor at Tyr(336) modulates opiate withdrawal. (2017 Nov)Zhang LEMBO Mol Med
17171661Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (2007 Apr 5)Beuten JAm J Med Genet B Neuropsychiatr Genet
22403532Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. (2012)El Rawas RFront Behav Neurosci
16825591Polymorphisms of the phosphodiesterase 4D, cAMP-specific (PDE4D) gene and risk of ischemic stroke: a prospective, nested case-control evaluation. (2006 Aug)Zee RYStroke
11978842Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal. (2002 May 1)Shaw-Lutchman TZJ Neurosci
12791581Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness. (2003 Aug 1)Singh SPAm J Respir Crit Care Med
11093800Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. (2000 Dec)Thibault CMol Pharmacol
24964093Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (2014)Breton CVPLoS One
18322102Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. (2008 Mar 5)Pandey SCJ Neurosci
22165966Gamma-amino butyric acid inhibits the nicotine-imposed stimulatory challenge in xenograft models of non-small cell lung carcinoma. (2012 Feb)Al-Wadei HACurr Cancer Drug Targets
19897079Therapeutic targeting of "DARPP-32": a key signaling molecule in the dopiminergic pathway for the treatment of opiate addiction. (2009)Mahajan SDInt Rev Neurobiol
11549750Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. (2001 Sep 15)Pliakas AMJ Neurosci
3036576Enhanced prostaglandin E2 and thromboxane B2 release from resident peritoneal macrophages isolated from morphine-dependent rats. (1987 Jun 8)Elliott GRFEBS Lett
14566342Regulation of gene expression and cocaine reward by CREB and DeltaFosB. (2003 Nov)McClung CANat Neurosci
29192123Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. (2018 Feb)Lin XMol Pharmacol
2632033[Effects of smoking on human health]. (1989 Oct)Du BYZhonghua Jie He He Hu Xi Za Zhi
21813678Identification of a dopamine receptor-mediated opiate reward memory switch in the basolateral amygdala-nucleus accumbens circuit. (2011 Aug 3)Lintas AJ Neurosci
2906541Disturbances in regulation of catecholamine neuromediation in alcoholism. (1988)Anokhina IPAlcohol Alcohol
11880521Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. (2002 Mar 1)Pu LJ Neurosci
19332462Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. (2009 Apr 14)Doser TACirculation
17180335Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats. (2007 Apr)Lynch WJPsychopharmacology (Berl)
19387337Prevention of pancreatic cancer by the beta-blocker propranolol. (2009 Jul)Al-Wadei HAAnticancer Drugs
26150803Intra-ventral tegmental area HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats. (2015)Zhu JFront Microbiol
23399681Pioglitazone potentiates development of morphine-dependence in mice: possible role of NO/cGMP pathway. (2013 May 13)Javadi SBrain Res
2164474Reduction of lymphocytic beta-adrenoceptor level in chronic alcoholics and rapid reversal after ethanol withdrawal. (1990 Jun)Maki TEur J Clin Invest
15029152Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. (2004 Jun)Valverde ONeuropsychopharmacology
2552861Human neutrophils are not severely injured in conditions mimicking social drinking. (1989 Aug)Corberand JXAlcohol Clin Exp Res
24874279Mechanism of antiplatelet action of hypolipidemic, antidiabetic and antihypertensive drugs by PPAR activation: PPAR agonists: new antiplatelet agents. (2014 Sep)Fuentes EVascul Pharmacol
16509757Clinical pharmacology of Cilomilast. (2006)Down GClin Pharmacokinet
22243740Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction. (2012 Jan 12)West AENeuron
28477089The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice. (2017 Aug)Liu XPsychopharmacology (Berl)
27921038The Clinical Manifestation and Management of Autosomal Dominant Polycystic Kidney Disease in China. (2016 Oct)Xue CKidney Dis (Basel)
23807873Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma. (2012 May 1)Schuller HMCurr Cancer Ther Rev
23778547[Comparison of prevalence estimates for health indicators in Campinas, Sao Paulo State, Brazil, in 2001-2002 (ISA-SP) and 2008-2009 (ISA-Camp)]. (2013 Jun)Francisco PMCad Saude Publica
28457032Prevalence of Cardiovascular Risk Factors among Diabetic Population and Awareness of Diabetes among Diabetic Patients: A Population Based Himalayan Study. (2017 Feb)Mokta JJ Assoc Physicians India
16775132Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. (2006 Jun 14)Chartoff EHJ Neurosci
23121078Phosphodiesterase-4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress. (2013 Jan)Ortiz JLAllergy
8662559Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. (1996 Aug 2)Maldonado RScience
23018909Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition. (2013 Jun)Milara JEur Respir J
19756388Neuroscience of alcoholism: molecular and cellular mechanisms. (2010 Jan)Moonat SCell Mol Life Sci
12847556BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. (2003 Summer)Garcia-Ladona FJCNS Drug Rev
15901846Long-term morphine treatment enhances proteasome-dependent degradation of G beta in human neuroblastoma SH-SY5Y cells: correlation with onset of adenylate cyclase sensitization. (2005 Aug)Mouledous LMol Pharmacol
18098271GABA B receptor is a novel drug target for pancreatic cancer. (2008 Feb 15)Schuller HMCancer
12614343In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice. (2003 Mar)Brunzell DHJ Neurochem
26805384Investigating the structural impact of S311C mutation in DRD2 receptor by molecular dynamics & docking studies. (2016 Apr)Podder ABiochimie
16846840HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells. (2006 Sep)Beltran JAInt Immunopharmacol
24682499The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice. (2014 Aug)Roni MAPsychopharmacology (Berl)
21232579Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. (2011 Mar 17)Kivinummi TNeurosci Lett
27709636PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma. (2017 May)Nieuwenhuis MAAllergy
25260978Differential modulation of nicotine-induced gemcitabine resistance by GABA receptor agonists in pancreatic cancer cell xenografts and in vitro. (2014 Sep 27)Banerjee JBMC Cancer
26740398Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function". (2016 Aug 15)Nestler EJBrain Res
20943775alpha4beta2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling. (2011 Jan)Hosur VMol Pharmacol
27766083Behavioral Neuroadaptation to Alcohol: From Glucocorticoids to Histone Acetylation. (2016)Mons NFront Psychiatry
21925237Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats. (2011 Nov 24)Alvaro-Bartolome MNeuroscience
19341783Protein receptor for activated C kinase 1 is involved in morphine reward in mice. (2009 Jul 7)Wan LNeuroscience
23237535Phosphodiesterase 8B gene polymorphism in women with recurrent miscarriage: a retrospective case control study. (2012 Dec 13)Granfors MBMC Med Genet
22453546Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats. (2012 Jul)Yoon SSPsychopharmacology (Berl)
20395237Effects of tadalafil on platelets and endothelium in patients with erectile dysfunction and cardiovascular risk factors: a pilot study. (2010 Aug)De Bon EAngiology
15475572Receptor endocytosis counteracts the development of opioid tolerance. (2005 Jan)Koch TMol Pharmacol
24452374A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. (2014 Mar 15)Oldenburger AAm J Physiol Cell Physiol
24905583beta2-Adrenoceptor involved in smoking-induced airway mucus hypersecretion through beta-arrestin-dependent signaling. (2014)Zhou YPLoS One
11907158Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase. (2002 Apr)Asher OJ Pharmacol Exp Ther
29031903Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats. (2018 Jan 5)Liu YEur J Pharmacol
23903008Acamprosate suppresses ethanol-induced place preference in mice with ethanol physical dependence. (2013)Kurokawa KJ Pharmacol Sci
15987941Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. (2005 Jun 29)Hucho TBJ Neurosci
2006395Alcohol and the small intestine. (1991 Jan)Persson JScand J Gastroenterol
23431157Contribution of alpha7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. (2013 Mar 5)Maouche KProc Natl Acad Sci U S A
24704371Epigenetic upregulation of PSD-95 contributes to the rewarding behavior by morphine conditioning. (2014 Jun 5)Wang ZEur J Pharmacol
17760784Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols. (2007 Sep)Kou JAlcohol Clin Exp Res
9465009Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. (1998 Mar 1)Self DWJ Neurosci
8702909Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma. (1996 Aug 30)Avidor-Reiss TJ Biol Chem
27567586Guduchi Sawras (Tinospora cordifolia): An Ayurvedic drug treatment modulates the impaired lipid metabolism in alcoholics through dopaminergic neurotransmission and anti-oxidant defense system. (2016 Oct)Shirolkar ABiomed Pharmacother
12715102[Changes in the phosphorylation of cAMP response element binding protein in the rat nucleus accumbens after acute and chronic ethanol administration]. (2003 Apr 25)Li JSheng Li Xue Bao
21193983Mice lacking adenylyl cyclase type 5 (AC5) show increased ethanol consumption and reduced ethanol sensitivity. (2011 May)Kim KSPsychopharmacology (Berl)
21671256Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release. (2011 Oct)Harashima SJ Neurosci Res
25051446Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. (2014 Oct)Vu CUEndocrinology
15353357Molecular and biological effects of hemodynamics on vascular cells. (2004 Sep 1)Pradhan SFront Biosci
24080315L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors. (2013 Dec 1)Xu WDrug Alcohol Depend
12605064Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. (2003 Feb)Pandey SCAlcohol Clin Exp Res
25939814CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. (2015 Aug)Chen JHum Brain Mapp
21481845Sex-specific role for adenylyl cyclase type 7 in alcohol dependence. (2011 Jun 1)Desrivieres SBiol Psychiatry
26861675D-Serine in the nucleus accumbens region modulates behavioral sensitization and extinction of conditioned place preference. (2016 Apr)Liu ZQPharmacol Biochem Behav
12090746An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. A WOSCOPS substudy. (2002 Jul)White HLEur Heart J
19914404Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model. (2010 Feb)Wang YJInt Immunopharmacol
20028368Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. (2010 Mar 1)Zhang HAlcohol Clin Exp Res
19890259Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. (2010 Feb)Wang JNeuropsychopharmacology
10235294Platelet adenylyl cyclase activity as a biochemical trait marker for predisposition to alcoholism. (1999 Apr)Ratsma JEAlcohol Clin Exp Res
8996236Chronic morphine treatment increases stimulatory beta-2 adrenoceptor signaling in A431 cells stably expressing the mu opioid receptor. (1997 Jan)Ammer HJ Pharmacol Exp Ther
17630319Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease. (2007 Dec)Hodge SAm J Respir Cell Mol Biol
16112088IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence. (2005 Oct 1)Wu NBiochem Pharmacol
21967557Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence. (2012 Mar)Li FAddict Biol
1306754[The biological mechanisms of a congenital predisposition to alcoholism]. (1992 Dec)Anokhina IPFiziol Zh Im I M Sechenova
7627955Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease. (1995 Aug 15)Park PGCancer Res
12853567The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. (2003 Jul 22)Zachariou VProc Natl Acad Sci U S A
19435931Beta 2 subunit-containing nicotinic receptors mediate acute nicotine-induced activation of calcium/calmodulin-dependent protein kinase II-dependent pathways in vivo. (2009 Aug)Jackson KJJ Pharmacol Exp Ther
8558448Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. (1996 Jan)Widnell KLJ Pharmacol Exp Ther
24755862Cigarette smoke and calcium conspire to impair CFTR function in airway epithelia. (2014)Braun APChannels (Austin)
8519505Molecular pharmacology of alpha 2-adrenoceptor subtypes. (1995 Aug)Aantaa RAnn Med
19054295Nicotine suppresses bone sialoprotein gene expression. (2009 Oct)Nakayama YJ Periodontal Res
27986643Cigarette smoke extracts induce overexpression of the proto-oncogenic gene interleukin-13 receptor alpha2 through activation of the PKA-CREB signaling pathway to trigger malignant transformation of lung vascular endothelial cells and angiogenesis. (2017 Feb)Meng MCell Signal
16684876Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats. (2006 May 16)Yao LProc Natl Acad Sci U S A
23999525Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence. (2014 Jul)Turner JRMol Psychiatry
18772347EphB receptor signaling in mouse spinal cord contributes to physical dependence on morphine. (2009 Jan)Liu WTFASEB J
10483516New insights in the bronchodilatory and anti-inflammatory mechanisms of action of theophylline. (1999 Aug)Juergens URArzneimittelforschung
8942401Lymphocyte cAMP and ageing: significance of subset composition, plasma noradrenaline, regular physical training and long-term smoking. (1996 Nov)Knudsen JHClin Sci (Lond)
27744406Long-Lasting Impairment of mGluR5-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration. (2017 Jan 1)Hoffmann HMInt J Neuropsychopharmacol
26521141Roflumilast partially reverses smoke-induced mucociliary dysfunction. (2015 Oct 31)Schmid ARespir Res
23682813Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase/cAMP pathway. (2014 Jan 1)Yang HYAntioxid Redox Signal
17008016Divergent anatomical pattern of D1 and D3 binding and dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa mRNA expression in the Roman rat strains: Implications for drug addiction. (2006 Nov 3)Guitart-Masip MNeuroscience
19001277Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. (2008 Nov 11)Bilbao AProc Natl Acad Sci U S A
8794897Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. (1996 Sep)Alvaro JDMol Pharmacol
29217682Overexpression of the Histone Dimethyltransferase G9a in Nucleus Accumbens Shell Increases Cocaine Self-Administration, Stress-Induced Reinstatement, and Anxiety. (2018 Jan 24)Anderson EMJ Neurosci
25392083Elevation of BDNF exon I-specific transcripts in the frontal cortex and midbrain of rat during spontaneous morphine withdrawal is accompanied by enhanced pCreb1 occupancy at the corresponding promoter. (2015 Jan)Peregud DINeurochem Res
15274052Association study of the Epac gene and tobacco smoking and nicotine dependence. (2004 Aug 15)Chen XAm J Med Genet B Neuropsychiatr Genet
28223412Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. (2017 Feb 21)Brust TFSci Signal
17147010Histone deacetylation: an important mechanism in inflammatory lung diseases. (2005 Dec)Adcock IMCOPD
16641242Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. (2006 Apr 26)Han MHJ Neurosci
15096214Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide attenuate the cigarette smoke extract-induced apoptotic death of rat alveolar L2 cells. (2004 May)Onoue SEur J Biochem
26113109Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle. (2015)Sathish VCell Physiol Biochem
18202306Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways. (2008 Apr)Yao LMol Pharmacol
16200210Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. (2005 Oct)Pandey SCJ Clin Invest
20613834Striatal microRNA controls cocaine intake through CREB signalling. (2010 Jul 8)Hollander JANature
23213073Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia. (2013 Feb)Al-Wadei MHCancer Prev Res (Phila)
18385331Brain chromatin remodeling: a novel mechanism of alcoholism. (2008 Apr 2)Pandey SCJ Neurosci
7969881Some biological mechanisms of the inborn predisposition to alcoholism. (1994 May-Jun)Anokhina IPNeurosci Behav Physiol
26680667Genetic predisposition of human plasma triglyceride concentrations. (2015)Schwarzova LPhysiol Res
12711604Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. (2003 Jul 11)Le Poul EJ Biol Chem
20519536Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice. (2010 Jun 2)Liu WTJ Neurosci
17147806Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum. (2006 Dec 5)Acquaah-Mensah GKBMC Genomics
14975676Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration. (2004 Mar)Garcia-Sevilla JANeuropharmacology
14729391Recent advances in the neurobiology of alcoholism: the role of adenosine. (2004 Jan)Mailliard WSPharmacol Ther
7971989Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. (1994 Nov 8)Widnell KLProc Natl Acad Sci U S A
22580231Downregulation of cAMP response element-binding protein by lentiviral vector-mediated RNAi attenuates morphine withdrawal syndromes in rats. (2012 Jul 15)Wu QBehav Brain Res
19549762Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons. (2009 Sep)Fan PMol Pharmacol
9694942Adenylyl cyclase supersensitivity in opioid-withdrawn NG108-15 hybrid cells requires Gs but is not mediated by the Gsalpha subunit. (1998 Aug)Ammer HJ Pharmacol Exp Ther
23653680Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: an in-vitro study. (2013)Pilakka-Kanthikeel SPLoS One
8519440Effect of S(-)- and R(+)-salsolinol on the POMC gene expression and ACTH release of an anterior pituitary cell line. (1995 Sep-Oct)Putscher IAlcohol
10907785Effects of passive smoking on the regulation of rat aortic cholesteryl ester hydrolases by signal transduction. (2000 May)Maehira FLipids
11259782Increased levels of calcium-sensitive adenylyl cyclase subtypes in the limbic system of alcoholics: evidence for a specific role of cAMP signaling in the human addictive brain. (2001 Mar 23)Yamamoto MBrain Res
29594872Calcium/calmodulin-stimulated adenylyl cyclases 1 and 8 regulate reward-related brain activity and ethanol consumption. (2018 Mar 28)Bosse KEBrain Imaging Behav
16200206The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism. (2005 Oct)Wand GJ Clin Invest
2953749Increased bone turnover during gonadotropin-releasing hormone superagonist-induced ovulation inhibition. (1987 Jul)Gudmundsson JAJ Clin Endocrinol Metab
16804413Ethanol and the tobacco-specific carcinogen, NNK, contribute to signaling in immortalized human pancreatic duct epithelial cells. (2006 Jul)Askari MDPancreas
27056740Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates. (2016 Jun 15)Garcia-Pardo MPEur J Pharmacol
28833174Enhanced motivation to alcohol in transgenic mice expressing human alpha-synuclein. (2017 Nov)Rotermund CJ Neurochem
29530590In vitro and in vivo functional profile characterization of 17-cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(isoquinoline-3-car boxamido)morphinan (NAQ) as a low efficacy mu opioid receptor modulator. (2018 May 15)Obeng SEur J Pharmacol
23318871Repeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin-producing neurons in the lateral hypothalamus in mice. (2013 Apr 1)Rao YJ Physiol
23867772Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine? (2013 Oct 22)Villalba RMNeuroscience
3006825[Enkephalin and cyclic nucleotide content in the brain structures of rats at different stages of the formation and development of alcoholic dependence]. (1986 Mar)Balakleevskii AIBiull Eksp Biol Med
16239108PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone. (2005 Nov)Al-Wadei HAEur J Cancer
16710312GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. (2007 Feb)Lhuillier LNeuropsychopharmacology
26044620Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. (2015 Jun 5)Reyes-Gibby CCBMC Syst Biol
19274673Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. (2009 Aug)Al-Wadei HAJ Pathol
28357120GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity. (2017 Apr)Sturchler EPharmacol Res Perspect
2376435914-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats. (2013 Sep)Mandal SFood Chem Toxicol
25471815alpha-Tocopherol protects renal cells from nicotine- or oleic acid-provoked oxidative stress via inducing heme oxygenase-1. (2015 Mar)Reed DKJ Physiol Biochem
16421965Changes of CREB in rat hippocampus, prefrontal cortex and nucleus accumbens during three phases of morphine induced conditioned place preference in rats. (2006 Feb)Zhou LFJ Zhejiang Univ Sci B
21433370Probe Report for NPY-Y2 Receptor Antagonists (2010)Saldanha SA-
20077763The common aspects of pathophysiolgy of alcoholism and depression. (2009 Dec)Ukai WNihon Arukoru Yakubutsu Igakkai Zasshi
15949588NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways. (2005 Jul)Schuller HMLung Cancer
17644756Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta. (2007 Oct)Ramirez AAm J Physiol Lung Cell Mol Physiol
17439498Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. (2007 Apr)Edwards SEur J Neurosci
14580925Efficacy of the novel phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). (2003)Grootendorst DCPulm Pharmacol Ther
9315909CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. (1997 Oct 15)Lane-Ladd SBJ Neurosci
29354053Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and DeltaFosB. (2017)Hasbi AFront Pharmacol
21420997Genetically expressed HIV-1 viral proteins attenuate nicotine-induced behavioral sensitization and alter mesocorticolimbic ERK and CREB signaling in rats. (2011 Jun)Midde NMPharmacol Biochem Behav
23717324MicroRNAs and Drug Addiction. (2013)Bali PFront Genet
22904357beta1-adrenoceptor activation is required for ethanol enhancement of lateral paracapsular GABAergic synapses in the rat basolateral amygdala. (2012 Nov)Silberman YJ Pharmacol Exp Ther
17550371Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats. (2007 Aug)Thorsell AAlcohol Clin Exp Res
27187237TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation. (2016 May 17)Aurelian LTransl Psychiatry
20729865Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. (2010 Sep)Yao LNat Med
1702982Beta-adrenoceptors in human alveolar macrophages isolated by elutriation. (1990 Nov)Hjemdahl PBr J Clin Pharmacol
25388276Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. (2016 Mar)Dominguez GBrain Struct Funct