Gene: GDF5

8200
BDA1C|BMP-14|BMP14|CDMP1|LAP-4|LAP4|OS5|SYM1B|SYNS2
growth differentiation factor 5
protein-coding
20q11.22
Ensembl:ENSG00000125965 MIM:601146 Vega:OTTHUMG00000032341 UniprotKB:P43026
NG_008076.3
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.235e-1 (AD)  7.236e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GMIP0.539
ABRA0.538
LPAR20.518
ARID3A0.5
OSCAR0.499
GYPA0.494
SYTL10.487
SIRPG0.485
ORC10.483
JAK30.477

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RERGL-0.277
MUSTN1-0.268
AKR7A3-0.26
BTBD17-0.252
GPR17-0.251
SLC22A6-0.249
SOX21-0.247
DIO2-0.245
RFTN2-0.242
MMD2-0.242

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02325Isopropyl AlcoholSmall Molecule67-63-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GDF5 mRNA"18648102
D000638AmiodaroneAmiodarone results in increased expression of GDF5 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GDF5 mRNA18830904
C015001arsenitearsenite results in increased methylation of GDF5 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GDF5 mRNA26001963
D001599BerberineBerberine results in decreased expression of GDF5 mRNA26478571
C006780bisphenol Abisphenol A results in increased methylation of GDF5 promoter27312807
C006780bisphenol Abisphenol A affects the expression of GDF5 mRNA25181051
C014347decitabinedecitabine results in increased expression of GDF5 mRNA27915011
D003976DiazinonDiazinon affects the expression of GDF5 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of GDF5 mRNA25016146
C069837fullerene C60fullerene C60 results in decreased expression of GDF5 mRNA19167457
D005938GlucocorticoidsGlucocorticoids results in decreased expression of GDF5 mRNA18830904
C008261lead acetatelead acetate results in increased expression of GDF5 mRNA22609695
D008070LipopolysaccharidesTriclosan inhibits the reaction [Lipopolysaccharides results in increased expression of GDF5 mRNA]20507366
C022838nickel chloridenickel chloride affects the expression of GDF5 mRNA22546817
C028007nickel monoxidenickel monoxide results in decreased expression of GDF5 mRNA19167457
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GDF5 mRNA26705709
D011239PrednisolonePrednisolone results in decreased expression of GDF5 mRNA18830904
D011374ProgesteroneProgesterone results in increased expression of GDF5 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of GDF5 mRNA24780913
D053260SootSoot results in increased expression of GDF5 mRNA26551751
D013739TestosteroneTestosterone results in decreased expression of GDF5 mRNA22138414
D014260TriclosanTriclosan inhibits the reaction [Lipopolysaccharides results in increased expression of GDF5 mRNA]20507366
C057693troglitazonetroglitazone results in increased expression of GDF5 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of GDF5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of GDF5 gene29154799
D015034Zinc OxideZinc Oxide affects the expression of GDF5 mRNA28648595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0005515protein binding-IPI16127465  18339631  19229295  21976273  24098149  
GO:0008083growth factor activity-IEA-  
GO:0036122BMP binding-IPI21976273  
GO:0042802identical protein binding-IPI25174448  
GO ID GO Term Qualifier Evidence PubMed
GO:0002062chondrocyte differentiation-IEA-  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS7961761  
GO:0007267cell-cell signaling-TAS8589725  
GO:0009612response to mechanical stimulus-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0030509BMP signaling pathway-IBA21873635  
GO:0030513positive regulation of BMP signaling pathway-IDA21976273  24098149  
GO:0032331negative regulation of chondrocyte differentiation-IDA21976273  
GO:0032332positive regulation of chondrocyte differentiation-IDA21976273  24098149  
GO:0035136forelimb morphogenesis-IEA-  
GO:0035137hindlimb morphogenesis-IEA-  
GO:0040014regulation of multicellular organism growth-IEA-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043932ossification involved in bone remodeling-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0048468cell development-IBA21873635  
GO:0050680negative regulation of epithelial cell proliferation-IDA9950587  
GO:0060390regulation of SMAD protein signal transduction-IDA21976273  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO:0060395SMAD protein signal transduction-IDA21976273  25092592  
GO:0060591chondroblast differentiation-IDA25092592  
GO:2001054negative regulation of mesenchymal cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21936909A genetic association study between growth differentiation factor 5 (GDF 5) polymorphism and knee osteoarthritis in Thai population. (2011 Sep 21)Tawonsawatruk TJ Orthop Surg Res
27207942Prospective cohort study of the risk factors for stress fractures in Chinese male infantry recruits. (2016 Aug)Zhao LJ Int Med Res