Gene: NCOA3

8202
ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP
nuclear receptor coactivator 3
protein-coding
20q13.12
Ensembl:ENSG00000124151 MIM:601937 Vega:OTTHUMG00000033061 UniprotKB:Q9Y6Q9
NG_016810.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.070e-2 (AD)  9.469e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNOT10.872
PROSER10.866
PBRM10.865
LRCH10.86
NUP1530.86
SOS10.86
CDK120.858
CCNT10.855
ZBTB380.855
NUMB0.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.454
OR4F29-0.421
S100A1-0.355
RBP1-0.311
BTBD17-0.308
HES5-0.3
SOX3-0.293
APOA1-0.285
C16orf74-0.279
PLA2G5-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"NCOA3 protein promotes the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of ESR2 protein alternative form]"27634370
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [NCOA3 protein binds to CYP1A1 promoter]"21703235
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene promotes the reaction [NCOA3 protein binds to GREB1 enhancer]"20846786
C0414773-hydroxyflavone3-hydroxyflavone promotes the reaction [NCOA3 protein binds to NR1I2 protein]26238175
C4967514-(1H-imidazol-1-yl)retinoic acid4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of NCOA3 protein17145897
C4967514-(1H-imidazol-1-yl)retinoic acid4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of NCOA3 protein17145897
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]"28751236
C5830744,4'-hexafluorisopropylidene diphenol"NCOA3 protein promotes the reaction [4,4'-hexafluorisopropylidene diphenol results in increased expression of ESR2 protein]"27634370
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NCOA3 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NCOA3 mRNA19770486
D013196DihydrotestosteroneNCOA3 protein promotes the reaction [Dihydrotestosterone results in increased expression of AR mRNA]16877366
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NCOA3 mRNA16483693
D000735AndrostenedioneAndrostenedione results in increased activity of NCOA3 protein16467117
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NCOA3 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of NCOA3 mRNA25929836
C037689benzamidebenzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]17157789
C037689benzamidebenzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]17157789
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NCOA3 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NCOA3 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOA3 mRNA"17944540|1915039
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NCOA3 mRNA"26238291
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of NCOA3 protein]16456540
D004958Estradiolbenzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]17157789
D004958EstradiolBRCA1 protein affects the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]18997820
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to H19 gene]]17962382
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to KLRC1 gene]]17962382
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to NKD1 gene]]17962382
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to SPATA13 gene]]17962382
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to TMEM121B gene]]17962382
D004958EstradiolEstradiol affects the localization of NCOA3 protein20079471
D004958EstradiolEstradiol inhibits the reaction [NCOA3 protein binds to CCNG2 promoter]22596188
D004958EstradiolEstradiol inhibits the reaction [TNF protein inhibits the reaction [NCOA3 protein binds to IL6 promoter]]24771768
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]17157789|1899782
D004958EstradiolEstradiol promotes the reaction [[ESR1 protein binds to NCOA3 protein] which binds to TFF1 promoter]17157789
D004958EstradiolEstradiol promotes the reaction [[NCOA3 protein binds to CYP2B6 promoter] which results in increased expression of CYP2B6 mRNA]20079471
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to ESR1 promoter]19620290
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]20846786
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]25721606
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to KLRC3 gene]17395694
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to PTGS2 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to TFF1 promoter]25721606
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]25721606
D004958EstradiolEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CYP1B1 promoter]]24299737
D004958EstradiolEstradiol results in decreased expression of NCOA3 mRNA16474171
D004958EstradiolEstradiol results in decreased expression of NCOA3 protein16739346
D004958EstradiolEstradiol results in increased phosphorylation of NCOA3 protein17157789
D004958Estradiol(+)-JQ1 compound affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]]25721606
D004958Estradiol(+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]]25721606
D004958EstradiolNCOA3 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]24771768
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol inhibits the reaction [NCOA3 protein binds to CCNG2 promoter]]22596188
D004958EstradiolNCOA3 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]27634370
D004958EstradiolEstradiol results in increased expression of NCOA3 mRNA20068009
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to ESR1 protein]17910454
C543008bis(4-hydroxyphenyl)sulfone[bis(4-hydroxyphenyl)sulfone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOA3 protein modified form]28751236
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]28751236
C006780bisphenol Abisphenol A results in decreased expression of NCOA3 mRNA16474171
C006780bisphenol Abisphenol A inhibits the reaction [Genistein results in decreased expression of NCOA3 protein]24884420
C006780bisphenol Abisphenol A results in decreased expression of NCOA3 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of NCOA3 protein21513798|2689883
C006780bisphenol Abisphenol A results in increased expression of NCOA3 protein19379760|1959068
C006780bisphenol AGenistein inhibits the reaction [bisphenol A results in increased expression of NCOA3 protein]24884420
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOA3 mRNA28628672
D000069286BortezomibBortezomib results in increased expression of NCOA3 mRNA20977926
C004605butambenbutamben promotes the reaction [NR1I2.L protein binds to NCOA3 protein]12198127
D002220CarbamazepineCarbamazepine affects the expression of NCOA3 mRNA24752500
C031180chrysenechrysene results in increased expression of NCOA3 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in increased expression of NCOA3 mRNA19376846
D003042CocaineCocaine affects the expression of NCOA3 mRNA20187946
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NCOA3 mRNA20971185
D003375CoumestrolCoumestrol results in decreased expression of NCOA3 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of NCOA3 mRNA20106945
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA3 protein modified form]28751236
C107676deguelindeguelin results in decreased expression of NCOA3 mRNA19365708
C107676deguelindeguelin results in decreased expression of NCOA3 protein19365708
D013759DronabinolDronabinol results in increased expression of NCOA3 mRNA16597638
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOA3 mRNA28628672
D002945CisplatinCisplatin promotes the reaction [NR1I2 protein binds to NCOA3 protein]15650019
D004008DiclofenacDiclofenac affects the expression of NCOA3 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NCOA3 mRNA26924002
D002117CalcitriolCalcitriol promotes the reaction [VDR protein binds to NCOA3 protein]15578590
D002117CalcitriolCalcitriol promotes the reaction [[VDR protein binds to NCOA3 protein] which binds to CYP24A1 promoter]15919092
D002117CalcitriolNCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRALPHA protein]]25279795
D002117CalcitriolNCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRA protein]]25279795
D002117CalcitriolNCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRB protein]]25279795
D002117CalcitriolNCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDR protein]]25279795
D002117CalcitriolNCOA3 protein results in increased susceptibility to Calcitriol25279795
D002117CalcitriolCalcitriol affects the localization of NCOA3 protein15647825
D002117CalcitriolCalcitriol promotes the reaction [NCOA3 protein binds to CYP24A1 promoter]15647825
D002117CalcitriolCalcitriol promotes the reaction [NCOA3 protein binds to SPP1 promoter]15647825
C118756dihydroxy-vitamin D3dihydroxy-vitamin D3 promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA3 protein modified form]20947021
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of NCOA3 mRNA26924002
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of NCOA3 mRNA"23811387
C547512eldecalcitoleldecalcitol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA3 protein modified form]20947021
D004970EstroneEstrone results in increased expression of NCOA3 mRNA21767602
D004970EstroneEstrone results in increased expression of NCOA3 protein21767602
C069837fullerene C60fullerene C60 results in increased expression of NCOA3 mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOA3 protein binds to IL6 promoter]]24771768
C037032galangingalangin promotes the reaction [NCOA3 protein binds to NR1I2 protein]26238175
C052659gambogic acidgambogic acid results in decreased expression of NCOA319433130
D019833GenisteinGenistein promotes the reaction [NCOA3 protein binds to ESR1 protein]27156127
D019833GenisteinGenistein results in decreased expression of NCOA3 mRNA16474171
D019833GenisteinNCOA3 protein promotes the reaction [Genistein results in increased expression of ESR2 protein]27634370
D019833GenisteinNCOA3 protein promotes the reaction [Genistein results in increased expression of ESR2 protein alternative form]27634370
D019833Genisteinbisphenol A inhibits the reaction [Genistein results in decreased expression of NCOA3 protein]24884420
D019833GenisteinGenistein inhibits the reaction [bisphenol A results in increased expression of NCOA3 protein]24884420
D019833GenisteinGenistein results in decreased expression of NCOA3 protein24884420
D005839GentamicinsGentamicins results in increased expression of NCOA3 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOA3 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of NCOA3 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOA3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]]25721606
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]]25721606
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NCOA3 mRNA24796395
C006552kaempferolkaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]20846786
C045463leflunomideleflunomide results in increased expression of NCOA3 mRNA28988120
C423914LG 268LG 268 promotes the reaction [NCOA3 protein binds to [RXRA protein binds to RXRA protein]]15310754
D008043Linseed OilLinseed Oil results in decreased expression of NCOA3 protein21138602
D008628MercuryMercury results in increased expression of NCOA3 mRNA16823088
D008727MethotrexateMethotrexate affects the expression of NCOA3 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NCOA3 mRNA28001369
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]28751236
D015741MetriboloneMetribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein]11981028
D015735MifepristoneMifepristone results in decreased expression of NCOA3 mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NCOA3 mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of NCOA3 mRNA26392148
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NCOA3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NCOA3 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of NCOA3 mRNA23811387
D009532NickelNickel results in increased expression of NCOA3 mRNA24768652
C028007nickel monoxidenickel monoxide results in increased expression of NCOA3 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NCOA3 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of NCOA3 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased acetylation of NCOA3 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of NCOA3 promoter] which results in decreased expression of NCOA3 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of NCOA3 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NCOA3 mRNA25729387
D017239PaclitaxelPaclitaxel promotes the reaction [NR1I2 protein binds to NCOA3 protein]15650019
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NCOA3 mRNA26272509
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased expression of NCOA3 mRNA16474171
D011374ProgesteroneProgesterone affects the expression of NCOA3 protein21291521
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to KLRC3 gene]17395694
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to PTGS2 promoter]17872375
C059514resveratrolfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOA3 protein binds to IL6 promoter]]24771768
C059514resveratrolNCOA3 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]24771768
C059514resveratrolresveratrol inhibits the reaction [TNF protein inhibits the reaction [NCOA3 protein binds to IL6 promoter]]24771768
C059514resveratrolresveratrol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]20846786
C059514resveratrolresveratrol results in decreased expression of NCOA3 mRNA18089832
C059514resveratrolresveratrol results in decreased expression of NCOA3 protein18089832
C059514resveratrolresveratrol inhibits the reaction [ESR1 protein binds to NCOA3 protein]24771768
D012402RotenoneRotenone results in increased expression of NCOA3 mRNA19013527
D012834SilverSilver results in decreased expression of NCOA3 mRNA27131904
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of NCOA3 mRNA"26680231
D013629Tamoxifenbenzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]17157789
D013629TamoxifenBRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]18997820
D013629TamoxifenNCOA3 results in decreased susceptibility to Tamoxifen21059860
D013629TamoxifenTamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]17157789
D013629TamoxifenTamoxifen promotes the reaction [[ESR1 protein binds to NCOA3 protein] which binds to TFF1 promoter]17157789
D013629TamoxifenTamoxifen promotes the reaction [NCOA3 protein binds to KLRC3 gene]17395694
D013629TamoxifenTamoxifen results in increased expression of NCOA3 mRNA20215421|2033231
D013629TamoxifenTamoxifen results in increased expression of NCOA3 protein20215421
D013629TamoxifenTamoxifen results in increased phosphorylation of NCOA3 protein17157789
C004648testosterone enanthatetestosterone enanthate results in increased expression of NCOA3 mRNA17440010
D013749TetrachlorodibenzodioxinEstradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CYP1B1 promoter]]24299737
D013749TetrachlorodibenzodioxinFOXA1 protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CCNG2 promoter]]22596188
D013749TetrachlorodibenzodioxinNCOA3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]12024042
D013749TetrachlorodibenzodioxinNCOA3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]12024042
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol inhibits the reaction [NCOA3 protein binds to CCNG2 promoter]]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[[AHR protein binds to NCOA3 protein binds to FOXA1 protein] which binds to CCNG2 promoter] which results in increased expression of CCNG2 mRNA]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[[AHR protein binds to NCOA3 protein binds to FOXA1 protein] which binds to CCNG2 promoter] which results in increased expression of CCNG2 protein]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CCNG2 promoter]22596188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CYP1A1 enhancer]12024042
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CYP1A1 promoter]21703235
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CYP1B1 promoter]24299737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NCOA3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NCOA3 mRNA26377647
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NCOA3 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of NCOA3 mRNA23228038
D014212Tretinoinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of NCOA3 protein]16456540
D014212Tretinoin[RARA protein binds to RXRA protein] promotes the reaction [Tretinoin results in increased degradation of NCOA3 protein]16456540
D014212TretinoinTretinoin promotes the reaction [NCOA3 protein binds to HAS2 promoter]17307735
D014212TretinoinTretinoin promotes the reaction [NCOA3 protein binds to RARA protein]16456540
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to NCOA3 protein]15578590
D014212Tretinoin[Tretinoin results in increased activity of MAPK14 protein] which results in increased phosphorylation of and results in increased degradation of NCOA3 protein16456540
D014212TretinoinTretinoin results in increased degradation of NCOA3 protein16456540
D014212TretinoinTretinoin results in increased expression of NCOA3 mRNA17218384|2372400
D014212TretinoinTretinoin results in increased phosphorylation of NCOA3 protein16456540
D014212TretinoinTretinoin results in increased expression of NCOA3 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of NCOA3 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of NCOA3 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NCOA3 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NCOA3 mRNA"23306105
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NCOA3 mRNA"24273086
C541743tris(2,3-dibromopropyl)isocyanurate"tris(2,3-dibromopropyl)isocyanurate results in decreased expression of NCOA3 mRNA"24273086
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of NCOA3 mRNA26562049
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of NCOA3 mRNA27776230
C057693troglitazonetroglitazone results in decreased expression of NCOA3 mRNA28973697
D014520UrethaneUrethane results in increased expression of NCOA3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCOA3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of NCOA3 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in increased expression of NCOA3 mRNA19101580
D015032ZincZinc deficiency results in increased expression of NCOA3 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000993RNA polymerase II core binding-ISS-  
GO:0003713transcription coactivator activity-IDA9238002  9267036  
GO:0003713transcription coactivator activity-IMP17223341  
GO:0003713transcription coactivator activity-NAS15572661  
GO:0004402histone acetyltransferase activity-IDA9267036  
GO:0005515protein binding-IPI10866661  11279242  11353774  11823864  11971985  12529369  
12917342  14645221  15698540  16439211  16456540  16938873  
16957778  17360478  17998543  21182203  21577200  23065768  
23514585  25303530  26153859  26267537  
GO:0016922ligand-dependent nuclear receptor binding-IBA21873635  
GO:0016922ligand-dependent nuclear receptor binding-IPI18798693  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0035257nuclear hormone receptor binding-IBA21873635  
GO:0035257nuclear hormone receptor binding-IDA9267036  
GO:0046966thyroid hormone receptor binding-NAS9346901  
GO:0046982protein heterodimerization activity-IMP11823864  
GO:0047485protein N-terminus binding-IPI12917342  
GO:0050681androgen receptor binding-NAS15572661  
GO:0097718disordered domain specific binding-IPI11823864  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0010628positive regulation of gene expression-IMP17223341  
GO:0016573histone acetylation-IEA-  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0032870cellular response to hormone stimulus-IBA21873635  
GO:0035624receptor transactivation-TAS17223341  
GO:0043697cell dedifferentiation-ISS-  
GO:0045618positive regulation of keratinocyte differentiation-IMP17082781  17223341  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9267036  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17082781  
GO:0071392cellular response to estradiol stimulus-IDA15831516  
GO:1902459positive regulation of stem cell population maintenance-ISS-  
GO:2000035regulation of stem cell division-ISS-  
GO:2001141regulation of RNA biosynthetic process-IMP17223341  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA15831516  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17223341  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA17223341  
GO:0005829cytosol-IDA-  
GO:0032991protein-containing complex-IMP11823864  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16244359The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. (2006 Mar)Colilla SCarcinogenesis