Gene: CANX

821
CNX|IP90|P90
calnexin
protein-coding
5q35.3
Ensembl:ENSG00000127022 MIM:114217 Vega:OTTHUMG00000130910 UniprotKB:P27824
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
9.702e-2 (AD)  6.753e-1 (ND)   (Frontal_Cortex)
3.815e-1 (AD)  1.328e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB100.946
HNRNPU0.934
UBE2H0.933
CAP10.932
NCOA40.93
HSPA90.929
ADIPOR10.928
HNRNPK0.928
ST130.922
EIF3J0.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.846
OR4F29-0.834
HMHB1-0.135
SPRR2B-0.127
RSPO1-0.124
TCL1A-0.123
OR6C74-0.119
OR4F16-0.116
C16orf97-0.114
LCE3A-0.112

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00025Antihemophilic factor, human recombinantBiotechDrug139076-62-3Approved|InvestigationalTarget
DB00031TenecteplaseBiotechDrug191588-94-0ApprovedTarget
DB06245LanoteplaseBiotechDrug171870-23-8InvestigationalTarget
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTarget
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTarget
DB13998Lonoctocog alfaBiotechDrug1388129-63-2Approved|InvestigationalTarget
DB13999Moroctocog alfaBiotechDrug284036-24-4ApprovedTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CANX mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of CANX mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CANX mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CANX mRNA16788091
D020106AcrylamideAcrylamide affects the expression of CANX mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CANX gene27153756
D024502alpha-Tocopherolalpha-Tocopherol affects the localization of CANX protein16908007
D024502alpha-Tocopherolalpha-Tocopherol results in increased expression of CANX mRNA16908007
D024502alpha-Tocopherolalpha-Tocopherol results in increased expression of CANX protein16908007
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CANX mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of CANX protein16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of CANX protein25419056
C006632arsenic trioxidearsenic trioxide results in increased expression of CANX mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of CANX protein25107562
C006632arsenic trioxideresveratrol inhibits the reaction [arsenic trioxide results in increased expression of CANX protein]25107562
D001241AspirinAspirin results in decreased expression of CANX mRNA15928584
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of CANX protein17912641
D004958EstradiolEstradiol results in increased expression of CANX mRNA19167446
C095105bexarotenebexarotene results in increased expression of CANX mRNA16648578
C006780bisphenol Abisphenol A affects the expression of CANX mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CANX mRNA25181051
C006780bisphenol Abisphenol A results in decreased methylation of CANX gene28505145
C006780bisphenol Abisphenol A results in increased methylation of CANX gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of CANX protein28903499
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CANX mRNA18804290
D000069287CapecitabineCANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]18678097
D002509CephaloridineCephaloridine results in increased expression of CANX mRNA18172885
D002994ClofibrateClofibrate results in increased expression of CANX mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of CANX mRNA21318169
C018021cobaltous chloridecobaltous chloride results in increased expression of CANX mRNA17553155
D019327Copper SulfateCopper Sulfate results in decreased expression of CANX mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of CANX mRNA11906922
D016572CyclosporineCyclosporine results in increased expression of CANX mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of CANX mRNA25270620
D016572CyclosporineCyclosporine results in increased expression of CANX mRNA18172885
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of CANX protein23811945
D016190CarboplatinCarboplatin results in decreased expression of CANX mRNA18172885
D003976DiazinonDiazinon results in increased methylation of CANX gene22964155
D002945CisplatinCisplatin results in decreased expression of CANX mRNA27392435
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of CANX mRNA21858171
D002945CisplatinCisplatin results in decreased expression of CANX mRNA18246545
D004041Dietary FatsDietary Fats results in increased expression of CANX mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of CANX mRNA]19030233
C007420dihydroxyaluminum aminoacetatedihydroxyaluminum aminoacetate results in decreased expression of CANX mRNA21432213
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of CANX mRNA27638505
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of CANX mRNA28939011
D004237DiuronDiuron results in decreased expression of CANX mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of CANX protein29385562
D004642EmodinEmodin results in decreased expression of CANX mRNA16045814
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CANX mRNA24534155
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CANX mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CANX protein23301498
D000431EthanolEthanol affects the expression of CANX mRNA11772933
D011345FenofibrateFenofibrate results in increased expression of CANX mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of CANX mRNA]21318169
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of CANX protein16908007
C000499ferric oxideferric oxide results in decreased expression of CANX protein25086211
D005472FluorouracilCANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]18678097
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of CANX mRNA]15016801
D005485FlutamideFlutamide results in increased expression of CANX mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of CANX mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of CANX mRNA19167457
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of CANX protein]20884965
D019833GenisteinGenistein results in increased expression of CANX protein20884965
D005839GentamicinsGentamicins results in increased expression of CANX mRNA18172885|2206182
D005947GlucoseGlucose results in decreased expression of CANX mRNA17178593
D017313FenretinideFenretinide results in increased expression of CANX protein17353921
D017313FenretinideFenretinide results in increased expression of CANX mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CANX mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CANX protein21179406
D002112CalcifediolCalcifediol deficiency results in decreased expression of CANX mRNA17293106
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of CANX mRNA19376150
C492448ICG 001ICG 001 results in decreased expression of CANX mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of CANX protein28315715
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CANX mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CANX protein25762632
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CANX mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CANX mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CANX mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CANX mRNA26272509
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CANX mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CANX mRNA"26251327
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to CANX protein]17220478
C059896miglustatmiglustat inhibits the reaction [CANX protein binds to CFTR protein mutant form]18230692
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of CANX mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA16357179
D009151Mustard GasMustard Gas results in increased phosphorylation of CANX protein19845377
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CANX protein"22001959
D009532NickelMT1 affects the reaction [Nickel affects the expression of CANX mRNA]16166738
D009532NickelMT2 affects the reaction [Nickel affects the expression of CANX mRNA]16166738
C028007nickel monoxidenickel monoxide results in decreased expression of CANX mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of CANX mRNA16780908
C012655nimesulidenimesulide results in increased expression of CANX mRNA24136188
D019319Okadaic AcidOkadaic Acid results in increased expression of CANX mRNA28939011
D010100OxygenOxygen deficiency results in increased expression of CANX mRNA24205000
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CANX mRNA23948077
D010795Phthalic AcidsPhthalic Acids results in increased expression of CANX mRNA21061450
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of CANX mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in increased expression of CANX mRNA18332044
C045950propiconazolepropiconazole results in increased expression of CANX mRNA21278054
C059514resveratrolresveratrol inhibits the reaction [arsenic trioxide results in increased expression of CANX protein]25107562
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of CANX mRNA]19030233
D012822Silicon DioxideSilicon Dioxide results in increased expression of CANX mRNA22431001
C009277sodium arsenatesodium arsenate results in increased expression of CANX mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of CANX mRNA28595984
C016104sodium bichromatesodium bichromate results in increased expression of CANX mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of CANX mRNA12325037
D012969Sodium FluorideSodium Fluoride results in increased expression of CANX protein27548804
D010042OuabainOuabain results in increased expression of CANX protein18247327
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of CANX mRNA16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CANX mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CANX mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of CANX mRNA"26680231
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Tunicamycin results in increased expression of CANX protein]27588471
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CANX mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CANX mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of CANX mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of CANX protein17353921
D019284ThapsigarginThapsigargin results in increased expression of CANX protein28315715
D013893ThiramThiram results in decreased expression of CANX mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of CANX mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CANX mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of CANX gene27618143
D014241TrichloroethyleneTrichloroethylene results in increased expression of CANX mRNA19448997
D014415TunicamycinERGIC3 protein inhibits the reaction [Tunicamycin results in increased expression of CANX protein]27588471
D014415Tunicamycintauroursodeoxycholic acid inhibits the reaction [Tunicamycin results in increased expression of CANX protein]27588471
D014415TunicamycinTunicamycin results in increased expression of CANX mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of CANX protein27588471
D014501UraniumUranium affects the expression of CANX mRNA15672453
D017974Uranium CompoundsUranium Compounds results in decreased expression of CANX mRNA19654044
C005460uranyl acetateuranyl acetate affects the expression of CANX mRNA15672453
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CANX mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of CANX mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CANX mRNA23179753|2718838
C025643vinclozolinvinclozolin affects the expression of CANX mRNA19015723
D024483Vitamin K 3Vitamin K 3 affects the expression of CANX mRNA20044591
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of CANX mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI12208510  16361248  16546175  17110338  17220478  17380188  
20528919  21205830  22190034  22314232  23826168  24764305  
25170080  29568061  
GO:0030246carbohydrate binding-IEA-  
GO:0034185apolipoprotein binding-IEA-  
GO:0035255ionotropic glutamate receptor binding-IEA-  
GO:0051082unfolded protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-TAS-  
GO:0006457protein folding-TAS-  
GO:0007568aging-IEA-  
GO:0009306protein secretion-TAS8055875  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0034975protein folding in endoplasmic reticulum-TAS22013210  
GO:0048488synaptic vesicle endocytosis-ISS-  
GO:0061077chaperone-mediated protein folding-IEA-  
GO:0070106interleukin-27-mediated signaling pathway-TAS-  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO:0072583clathrin-dependent endocytosis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA14966132  18458083  21190736  22572157  23826168  24263861  24454821  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005789endoplasmic reticulum membrane-IDA19723497  20531390  23814182  
GO:0005790smooth endoplasmic reticulum-IEA-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0005840ribosome-IEA-  
GO:0016020membrane-HDA19946888  
GO:0030424axon-IEA-  
GO:0032839dendrite cytoplasm-IEA-  
GO:0042470melanosome-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0044233ER-mitochondrion membrane contact site-IDA23455425  
GO:0044322endoplasmic reticulum quality control compartment-IEA-  
GO:0070062extracellular exosome-HDA23533145  
GO:0070062extracellular exosomeNOTIDA21235781  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
hsa04145Phagosome
hsa04612Antigen processing and presentation
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1643685DiseaseTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168255Influenza Life CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168268Virus Assembly and ReleaseTAS
R-HSA-168316Assembly of Viral Components at the Budding SiteTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-532668N-glycan trimming in the ER and Calnexin/Calreticulin cycleTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-901042Calnexin/calreticulin cycleTAS
R-HSA-9020956Interleukin-27 signalingTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCIEA
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18671841PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells. (2008 Jul 31)Kriegova EBMC Mol Biol