Gene: SYN3

8224
-
synapsin III
protein-coding
22q12.3
Ensembl:ENSG00000185666 MIM:602705 Vega:OTTHUMG00000031004 UniprotKB:O14994
NG_029545.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.802e-1 (AD)  3.380e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTUS20.922
SCN8A0.916
PCDHGC50.904
KCNH10.899
LHFPL40.899
CACNG20.897
KSR20.894
KIAA13240.891
CACNA1D0.891
C1QL30.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.567
HEY2-0.55
CSAG1-0.533
RAB13-0.531
ROM1-0.523
MYL3-0.519
YES1-0.514
RNF135-0.509
GNG11-0.509
RARRES2-0.496

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SYN3 mRNA"19114083
D020106AcrylamideAcrylamide results in increased expression of SYN3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SYN3 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SYN3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYN3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of SYN3 mRNA15761015
C015001arsenitearsenite results in decreased methylation of SYN3 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of SYN3 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYN3 mRNA20938992
D003042CocaineSYN3 protein affects the reaction [Cocaine results in increased secretion of Dopamine]16554471
C000944dicrotophosdicrotophos results in increased expression of SYN3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of SYN3 mRNA25016146
D004298DopamineSYN3 protein affects the reaction [Cocaine results in increased secretion of Dopamine]16554471
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYN3 mRNA20938992
C008261lead acetatelead acetate results in increased expression of SYN3 mRNA22609695
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYN3 mRNA20938992
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SYN3 mRNA"15329391
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SYN3 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SYN3 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of SYN3 mRNA]"21673326
D010269ParaquatParaquat affects the expression of SYN3 mRNA16854511
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SYN3 mRNA21061450
D010936Plant ExtractsPlant Extracts results in decreased expression of SYN3 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of SYN3 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SYN3 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of SYN3 mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of SYN3 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of SYN3 mRNA12760830
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SYN3 promoter]19654925
D014635Valproic AcidValproic Acid results in decreased methylation of SYN3 gene29154799
C025643vinclozolinvinclozolin affects the expression of SYN3 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of SYN3 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-TAS15217342  
GO ID GO Term Qualifier Evidence PubMed
GO:0007269neurotransmitter secretion-IBA21873635  
GO:0007269neurotransmitter secretion-IEA-  
GO:0032228regulation of synaptic transmission, GABAergic-TAS15217342  
GO ID GO Term Qualifier Evidence PubMed
GO:0008021synaptic vesicle-TAS9539796  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0030672synaptic vesicle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25893111Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. (2015)Chavali VRJ Clin Med