Gene: CAPN3

825
CANP3|CANPL3|LGMD2|LGMD2A|nCL-1|p94
calpain 3
protein-coding
15q15.1
Ensembl:ENSG00000092529 MIM:114240 Vega:OTTHUMG00000130619 UniprotKB:P20807
NG_008660.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.243e-1 (AD)  2.762e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23198793chr15:42694406CAPN36.600e-19Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYRF0.951
MOG0.939
KLK60.937
GJB10.934
MAG0.934
FA2H0.926
SLC45A30.92
ENPP20.918
TF0.917
PLEKHH10.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.338
PAX2-0.331
NPBWR1-0.324
CNGB1-0.318
OR4F29-0.316
OR4F5-0.306
WTIP-0.304
NEUROD1-0.297
LTK-0.291
CHRNA6-0.288

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06124L-aminocarnityl-succinyl-leucyl-argininal-diethylacetalSmall Molecule1006685-44-4InvestigationalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAPN3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAPN3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CAPN3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CAPN3 gene27153756
C103303alitretinoinalitretinoin results in decreased expression of CAPN3 mRNA28689802
D000638AmiodaroneAmiodarone results in increased expression of CAPN3 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CAPN3 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CAPN3 mRNA26001963
C095105bexarotenebexarotene analog results in decreased expression of CAPN3 mRNA28689802
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CAPN3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CAPN3 mRNA25181051
C031180chrysenechrysene results in increased expression of CAPN3 mRNA26377693
D003471CuprizoneCuprizone results in increased expression of CAPN3 mRNA26577399
D016572CyclosporineCyclosporine results in increased methylation of CAPN3 promoter27989131
D003620DantroleneDantrolene results in decreased expression of CAPN3 mRNA11236903
D003620DantroleneDantrolene results in decreased expression of CAPN3 protein11236903
C014347decitabinedecitabine results in decreased expression of CAPN3 mRNA17785578
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CAPN3 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CAPN3 mRNA28962523
D004026DieldrinDieldrin results in increased expression of CAPN3 mRNA28385952
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CAPN3 mRNA"22485181
D005419FlavonoidsFlavonoids results in decreased expression of CAPN3 mRNA18035473
D005485FlutamideFlutamide results in increased expression of CAPN3 mRNA21126777
C039281furanfuran results in decreased expression of CAPN3 mRNA24183702
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CAPN3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAPN3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CAPN3 mRNA28628672
C008261lead acetatelead acetate results in decreased expression of CAPN3 mRNA21891863
C045463leflunomideleflunomide results in increased expression of CAPN3 mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CAPN3 mRNA26378955
D009151Mustard GasMustard Gas results in increased expression of CAPN3 mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CAPN3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CAPN3 mRNA"25620056
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CAPN3 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CAPN3 mRNA25729387
D010575PesticidesPesticides results in increased methylation of CAPN3 gene28396702
D010634PhenobarbitalPhenobarbital results in increased expression of CAPN3 mRNA12832660
D010936Plant ExtractsPlant Extracts results in increased expression of CAPN3 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of CAPN3 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of CAPN3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CAPN3 mRNA24780913
D053260SootSoot results in increased expression of CAPN3 mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CAPN3 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAPN3 mRNA22574217
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CAPN3 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CAPN3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CAPN3 mRNA28689802
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAPN3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CAPN3 mRNA26272509
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CAPN3 gene25560391
C025643vinclozolinvinclozolin results in increased expression of CAPN3 mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IDA9642272  
GO:0004198calcium-dependent cysteine-type endopeptidase activity-IBA21873635  
GO:0004198calcium-dependent cysteine-type endopeptidase activity-ISS-  
GO:0004198calcium-dependent cysteine-type endopeptidase activity-TAS9642272  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI20860623  23414517  25416956  
GO:0008233peptidase activity-IDA9642272  
GO:0008234cysteine-type peptidase activity-TAS2555341  
GO:0008307structural constituent of muscle-ISS-  
GO:0031402sodium ion binding-ISS-  
GO:0031432titin binding-IPI9642272  18310072  
GO:0032947protein-containing complex scaffold activity-ISS-  
GO:0055103ligase regulator activity-IDA20694146  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IDA9642272  18310072  19386580  20694146  
GO:0006915apoptotic process-TAS19386580  
GO:0007517muscle organ development-TAS9642272  
GO:0014718positive regulation of satellite cell activation involved in skeletal muscle regeneration-ISS-  
GO:0014850response to muscle activity-ISS-  
GO:0030239myofibril assembly-ISS-  
GO:0030239myofibril assembly-TAS9642272  
GO:0033234negative regulation of protein sumoylation-IDA20694146  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IMP18073330  
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling-IMP18073330  
GO:0045214sarcomere organization-ISS-  
GO:0045661regulation of myoblast differentiation-IEA-  
GO:0045862positive regulation of proteolysis-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IMP18073330  
GO:0046716muscle cell cellular homeostasis-TAS19386580  
GO:0050790regulation of catalytic activity-IDA20694146  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP18073330  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-ISS-  
GO:0051592response to calcium ion-ISS-  
GO:0061061muscle structure development-ISS-  
GO:0065003protein-containing complex assembly-ISS-  
GO:0070315G1 to G0 transition involved in cell differentiation-IEA-  
GO:0071277cellular response to calcium ion-ISS-  
GO:0071472cellular response to salt stress-ISS-  
GO:0072657protein localization to membrane-ISS-  
GO:0097264self proteolysis-IDA9642272  
GO:2001015negative regulation of skeletal muscle cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-TAS9642272  
GO:0005634nucleus-IDA19386580  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA19386580  19556129  
GO:0005829cytosol-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0030016myofibril-ISS-  
GO:0030018Z disc-ISS-  
GO:0030315T-tubule-ISS-  
GO:0032991protein-containing complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28332615Integrative variants, haplotypes and diplotypes of the CAPN3 and FRMD5 genes and several environmental exposures associate with serum lipid variables. (2017 Mar 23)Guo TSci Rep