Gene: TKTL1

8277
TKR|TKT2
transketolase like 1
protein-coding
Xq28
Ensembl:ENSG00000007350 MIM:300044 Vega:OTTHUMG00000022707 UniprotKB:P51854
NG_028264.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD440.767
TIMP10.767
GBP20.737
TNFRSF12A0.731
SLC1A50.73
PYGL0.73
PLEKHA40.716
IGFLR10.709
COL4A10.708
MMP140.707

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRM1-0.504
NEUROD6-0.501
MARCH4-0.495
SLC7A4-0.486
CDK5R2-0.479
EXTL1-0.475
BCL11A-0.471
KCNQ4-0.468
KIT-0.466
ST6GALNAC5-0.464

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TKTL1 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TKTL1 mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TKTL1 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of TKTL1 mRNA28959563
D000638AmiodaroneAmiodarone results in increased expression of TKTL1 mRNA19774075
C006780bisphenol Abisphenol A results in decreased expression of TKTL1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of TKTL1 mRNA25979313
D003300CopperCopper deficiency results in increased expression of TKTL1 mRNA26033743
C014347decitabinedecitabine results in increased expression of TKTL1 mRNA17194187|2185625
C008261lead acetatelead acetate results in increased expression of TKTL1 mRNA22641619
D008727MethotrexateMethotrexate affects the expression of TKTL1 mRNA18502557
D010100OxygenIL15 protein affects the reaction [Oxygen deficiency results in increased expression of TKTL1 mRNA]27129235
D010100OxygenOxygen deficiency results in increased expression of TKTL1 mRNA27129235
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
C017947sodium arsenitesodium arsenite results in increased expression of TKTL1 mRNA17879257
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TKTL1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TKTL1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TKTL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TKTL1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of TKTL1 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of TKTL1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004802transketolase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006007glucose catabolic process-TAS8838793  
GO:0006772thiamine metabolic process-TAS8838793  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa00030Pentose phosphate pathway
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27093812[Expression and clinical significance of MTDH, HIF-1alpha and TKTL1 in laryngeal carcinoma]. (2015 Dec)Jia XLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
22445516TKTL-1 expression in lung cancer. (2012 Apr 15)Fritz PPathol Res Pract