Gene: CAPS

828
CAPS1
calcyphosine
protein-coding
19p13.3
Ensembl:ENSG00000105519 MIM:114212 Vega:OTTHUMG00000180619 UniprotKB:Q13938
NC_000019.10
PubMed
CD|ND|AD
21   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.411e-1 (AD)  7.495e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC1590.833
SLC12A90.815
MUTYH0.789
RNPEPL10.778
PPP2R3B0.776
TRPV10.763
HIP1R0.756
LSS0.751
ARHGEF10.75
USP400.749

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.467
OR4F29-0.432
FER1L6-0.302
IBSP-0.298
MUC15-0.275
GCSAM-0.274
LBH-0.274
KRT73-0.267
UNC45B-0.26
C10orf113-0.253

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTarget
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTarget
ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CAPS mRNA24449571
D004958EstradiolEstradiol results in increased expression of CAPS mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of CAPS mRNA23019147
C018475butyraldehydebutyraldehyde results in decreased expression of CAPS mRNA26079696
C480342clothianidinclothianidin results in decreased expression of CAPS mRNA29044138
D019327Copper SulfateCopper Sulfate results in decreased expression of CAPS mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CAPS mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CAPS mRNA18936297
D019833GenisteinGenistein results in increased expression of CAPS mRNA23019147|2686566
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CAPS mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CAPS mRNA27392435
C046012pentanalpentanal results in decreased expression of CAPS mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CAPS mRNA25895662
D014212TretinoinTretinoin results in decreased expression of CAPS mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CAPS mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CAPS mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of CAPS gene29154799
D024483Vitamin K 3CAPS affects the susceptibility to Vitamin K 322715409

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0035556intracellular signal transduction-TAS2540953  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0031982vesicle-HDA19190083  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28489501Smoking Cessation Treatment for Patients With Mental Disorders Using CBT and Combined Pharmacotherapy. (2017 Oct-Dec)Loreto ARJ Dual Diagn
29625852Double-blind evaluation of homeopathy on cocaine craving: a randomized controlled pilot study. (2018 May)Adler UCJ Integr Med
16901505Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. (2007 Nov)von Kanel RJ Psychiatr Res
26378685Development of new atherosclerotic plaque in hypertensive patients: an observational registry study from the Campania-Salute network. (2015 Dec)Izzo RJ Hypertens
28117141Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study. (2017 Apr)Liu LEnviron Int
16868270Altered blood coagulation in patients with posttraumatic stress disorder. (2006 Jul-Aug)von Kanel RPsychosom Med
12237954Evidence that anandamide-signaling regulates human sperm functions required for fertilization. (2002 Nov)Schuel HMol Reprod Dev
20034532Alcohol influence on acrylamide to glycidamide metabolism assessed with hemoglobin-adducts and questionnaire data. (2010 Mar)Vikstrom ACFood Chem Toxicol
27638184Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study. (2017 Jan)Lindqvist DBrain Behav Immun
18190729beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder. (2008 May)Czermak CInt J Neuropsychopharmacol
17454716Factor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit. (2007 May)Toll BANicotine Tob Res
12624278Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS). (2003 Mar)Risley PStroke
19372452Fractalkine receptor/ligand genetic variants and carotid intima-media thickness. (2009 Jun)Debette SStroke
27112218Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of post-traumatic stress disorder. (2016 Jul)Svob Strac DStress
20464179[Characterization of admission of chemical-dependents in a psychiatric admission unit of the general hospital]. (2010 May)Sousa FSCien Saude Colet
6889242Contraception today. (1983 May)Rowlands SPractitioner
8879945Pathophysiology and initial management of the acute coronary syndromes. (1996 Jul)Giri SCurr Opin Cardiol
17332447Toll receptor polymorphisms and carotid artery intima-media thickness. (2007 Apr)Labrum RStroke
29609056Smoking cessation treatment outcomes among people with and without mental and substance use disorders: An observational real-world study. (2018 Mar 30)Castaldelli-Maia JMEur Psychiatry
25137119Retention predictors of a smoking treatment provided by a public psychosocial unit in Brazil. (2014 Aug)Castaldelli-Maia JMInt Rev Psychiatry
29084628First description and evaluation of SNPs in the ADH and ALDH genes in a population of alcoholics in Central-West Brazil. (2017 Dec)Teixeira TMAlcohol