Gene: EPX

8288
EPO|EPP|EPX-PEN|EPXD
eosinophil peroxidase
protein-coding
17q22
Ensembl:ENSG00000121053 MIM:131399 Vega:OTTHUMG00000178802 UniprotKB:P11678
NG_013020.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.763e-2 (AD)  5.844e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMLN0.819
DOPEY10.812
ZNF3820.803
CAPRIN20.8
CCDC390.796
TRIM660.795
TRANK10.793
L3MBTL10.792
MASP20.792
ZNF1690.786

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.446
PGF-0.409
PDZK1IP1-0.407
ROM1-0.4
MYL3-0.399
PPP1R14B-0.391
EIF4EBP1-0.383
BCL7C-0.381
EMP3-0.379
S100A16-0.378

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01065MelatoninSmall Molecule73-31-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of EPX mRNA26690555
D001104ArbutinArbutin results in increased expression of EPX mRNA17103032
C006632arsenic trioxidearsenic trioxide results in increased expression of EPX mRNA15070760|1576101
D001507BeclomethasoneBeclomethasone results in decreased expression of EPX protein8535097
D001507BeclomethasoneBeclomethasone inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
D001623BetamethasoneBetamethasone results in decreased expression of EPX protein8535097
C006780bisphenol Abisphenol A results in decreased expression of EPX mRNA25181051
D001761BleomycinBleomycin results in increased expression of EPX protein26093215
D019819BudesonideBudesonide inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
D020148Butyric AcidButyric Acid results in increased expression of EPX protein14769150
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of EPX mRNA24763279
C102660CDP 840CDP 840 inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C026690cerous chloridecerous chloride results in decreased expression of EPX mRNA28954213
C433247CilomilastCilomilast inhibits the reaction [Lipopolysaccharides results in increased secretion of EPX protein]11907180
C433247CilomilastCilomilast inhibits the reaction [ovalbumin-alum results in increased secretion of EPX protein]11907180
D002994ClofibrateClofibrate results in decreased expression of EPX mRNA22300585
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EPX mRNA23914054
D003907DexamethasoneDexamethasone inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
D002945CisplatinCisplatin results in decreased expression of EPX mRNA27594783
D000068298FluticasoneFluticasone inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
D004397FonofosFonofos results in increased methylation of EPX promoter22847954
C039281furanfuran results in increased methylation of EPX gene22079235
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of EPX mRNA24763279
C028521lanthanum chloridelanthanum chloride results in increased expression of EPX mRNA28954213
C008261lead acetatelead acetate results in decreased expression of EPX mRNA22609695
D008070LipopolysaccharidesCilomilast inhibits the reaction [Lipopolysaccharides results in increased secretion of EPX protein]11907180
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of EPX protein11907180
D008070LipopolysaccharidesNVP ABE171 inhibits the reaction [Lipopolysaccharides results in increased secretion of EPX protein]11907180
D008727MethotrexateMethotrexate affects the expression of EPX mRNA18502557
C451724NVP ABE171NVP ABE171 inhibits the reaction [Lipopolysaccharides results in increased secretion of EPX protein]11907180
C451724NVP ABE171NVP ABE171 inhibits the reaction [ovalbumin-alum results in increased secretion of EPX protein]11907180
D010047OvalbuminOvalbumin results in increased expression of EPX protein12794006
D010047OvalbuminPH 163 inhibits the reaction [Ovalbumin results in increased expression of EPX protein]12794006
D010047Ovalbuminverlukast inhibits the reaction [Ovalbumin results in increased expression of EPX protein]12794006
D010047Ovalbuminzileuton inhibits the reaction [Ovalbumin results in increased expression of EPX protein]12794006
C446402ovalbumin-alumCilomilast inhibits the reaction [ovalbumin-alum results in increased secretion of EPX protein]11907180
C446402ovalbumin-alumNVP ABE171 inhibits the reaction [ovalbumin-alum results in increased secretion of EPX protein]11907180
C446402ovalbumin-alumovalbumin-alum results in increased secretion of EPX protein11907180
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of EPX mRNA]21688324
D010269ParaquatParaquat results in decreased expression of EPX mRNA21688324
D010278ParathionParathion results in increased methylation of EPX promoter22847954
C104857PH 163PH 163 inhibits the reaction [Ovalbumin results in increased expression of EPX protein]12794006
C087566piclamilastpiclamilast results in decreased expression of EPX protein8535097
C087566piclamilastpiclamilast inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
D020889RolipramRolipram inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexBeclomethasone inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexBudesonide inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexCDP 840 inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexDexamethasone inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexFluticasone inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexpiclamilast inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexRolipram inhibits the reaction [sephadex results in increased expression of EPX protein]10850854
C025614sephadexsephadex results in increased expression of EPX protein10850854
D012834SilverSilver results in decreased expression of EPX mRNA19429238
D053260SootSoot results in increased expression of EPX mRNA21914721
C061133tamibarotenetamibarotene results in decreased expression of EPX mRNA15498508
C012568terbufosterbufos results in increased methylation of EPX promoter22847954
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of EPX mRNA20189893
D014212TretinoinTretinoin results in decreased expression of EPX mRNA15498508
C012589trichostatin Atrichostatin A results in decreased expression of EPX mRNA15901671
D014635Valproic AcidValproic Acid results in increased methylation of EPX gene29154799
D014635Valproic AcidValproic Acid affects the expression of EPX mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of EPX mRNA15901671
C059141verlukastverlukast inhibits the reaction [Ovalbumin results in increased expression of EPX protein]12794006
C063449zileutonzileuton inhibits the reaction [Ovalbumin results in increased expression of EPX protein]12794006

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activity-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002215defense response to nematode-IEA-  
GO:0006979response to oxidative stress-IEA-  
GO:0032693negative regulation of interleukin-10 production-IEA-  
GO:0032714negative regulation of interleukin-5 production-IEA-  
GO:0032753positive regulation of interleukin-4 production-IEA-  
GO:0042742defense response to bacterium-IBA21873635  
GO:0042744hydrogen peroxide catabolic process-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO:0072677eosinophil migration-IEA-  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa05310Asthma
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27552197Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17+ Cells in Asthmatic Airways. (2016)Fattahi FPLoS One
22531693Oxidative balance and colon and rectal cancer: interaction of lifestyle factors and genes. (2012 Jun 1)Slattery MLMutat Res
27477800Low-grade disease activity in early life precedes childhood asthma and allergy. (2016 Aug)Chawes BLDan Med J
8630596Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking. (1996 May)Pedersen BAm J Respir Crit Care Med