Gene: ARID1A

8289
B120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1
AT-rich interaction domain 1A
protein-coding
1p36.11
Ensembl:ENSG00000117713 MIM:603024 Vega:OTTHUMG00000004004 UniprotKB:O14497
NG_029965.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.054e-1 (AD)  9.189e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13867915chr1:27050039ARID1A3.900e-14Smoking27651444
cg22042546chr1:27050491ARID1A2.600e-8Smoking27651444
cg05649922chr1:27029290ARID1A7.670e-12Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRCAP0.903
EP3000.901
TRRAP0.899
SNRNP2000.897
ANKFY10.893
CPSF70.893
CHD80.892
EP4000.892
KDM3B0.891
MINK10.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.659
OR4F29-0.609
KLRC2-0.329
CD8B-0.301
NANOGNB-0.283
PAGE4-0.265
SIM1-0.259
OR6C74-0.258
ODAM-0.253
KLRC3-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARID1A mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARID1A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARID1A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARID1A mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ARID1A mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARID1A mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ARID1A mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID1A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ARID1A mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ARID1A gene27153756
C006632arsenic trioxideARID1A protein results in increased susceptibility to arsenic trioxide20707922
C006632arsenic trioxidearsenic trioxide results in increased sumoylation of ARID1A protein28318385
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of ARID1A mRNA"17331233
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARID1A mRNA"19150397|2001819
C006780bisphenol Abisphenol A results in increased expression of ARID1A mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of ARID1A mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ARID1A mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARID1A gene20938992
D002994ClofibrateClofibrate results in decreased expression of ARID1A mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARID1A mRNA19376846
D003976DiazinonDiazinon results in increased methylation of ARID1A gene22964155
D002945CisplatinCisplatin results in decreased expression of ARID1A mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of ARID1A mRNA28302478
D011397PromegestonePromegestone promotes the reaction [ARID1A protein binds to PGR protein]19609353
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ARID1A protein23301498
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARID1A gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ARID1A mRNA20655997
C070081fulvestrantfulvestrant results in increased expression of ARID1A protein24169358
C039281furanfuran results in increased methylation of ARID1A gene22079235
D005839GentamicinsGentamicins results in increased expression of ARID1A mRNA22061828
D007213IndomethacinIndomethacin results in decreased expression of ARID1A mRNA16984733
C544151jinfukangjinfukang results in decreased expression of ARID1A mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of ARID1A mRNA16807920
D008628MercuryMercury results in increased expression of ARID1A mRNA19937285
D008694MethamphetamineMethamphetamine results in increased expression of ARID1A mRNA26307267
D008694MethamphetamineMethamphetamine results in increased methylation of ARID1A promoter26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARID1A gene20938992
D008727MethotrexateMethotrexate affects the expression of ARID1A mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ARID1A mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARID1A mRNA"27188386
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ARID1A mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARID1A mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of ARID1A mRNA24136188
D009538NicotineNicotine results in decreased expression of ARID1A mRNA17997037
C016030pantogabpantogab results in decreased expression of ARID1A mRNA17379144
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARID1A mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ARID1A mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ARID1A protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of ARID1A mRNA23091169
D010936Plant ExtractsPlant Extracts results in decreased expression of ARID1A mRNA23557933
C024273profenofosprofenofos results in decreased expression of ARID1A mRNA17569032
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ARID1A mRNA21427059
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ARID1A mRNA"26680231
C012589trichostatin Atrichostatin A affects the expression of ARID1A mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of ARID1A mRNA28973697
D014635Valproic AcidValproic Acid results in increased methylation of ARID1A gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of ARID1A mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ARID1A gene25560391
C025643vinclozolinvinclozolin results in increased expression of ARID1A mRNA23034163
D015032ZincZinc deficiency results in increased expression of ARID1A mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IDA23129809  
GO:0003677DNA binding-NAS10757798  
GO:0003713transcription coactivator activity-NAS8804307  
GO:0005515protein binding-IPI11780067  11988099  12200431  12368262  15985610  17363140  
19486893  23540691  
GO:0016922ligand-dependent nuclear receptor binding-IPI17363140  
GO:0031491nucleosome binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001704formation of primary germ layer-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0003205cardiac chamber development-IEA-  
GO:0003408optic cup formation involved in camera-type eye development-IEA-  
GO:0006337nucleosome disassembly-IDA8895581  
GO:0006338chromatin remodeling-IDA11726552  
GO:0006344maintenance of chromatin silencing-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-NAS8804307  
GO:0007566embryo implantation-IEA-  
GO:0019827stem cell population maintenance-IEA-  
GO:0030520intracellular estrogen receptor signaling pathway-IDA12200431  
GO:0030521androgen receptor signaling pathway-IDA12200431  
GO:0030900forebrain development-IEA-  
GO:0042766nucleosome mobilization-TAS12200431  
GO:0042921glucocorticoid receptor signaling pathway-IDA12200431  
GO:0043044ATP-dependent chromatin remodeling-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA12200431  
GO:0048096chromatin-mediated maintenance of transcription-TAS12200431  
GO:0055007cardiac muscle cell differentiation-IEA-  
GO:0060674placenta blood vessel development-IEA-  
GO:0071277cellular response to calcium ion-HEP21237226  
GO:1901998toxin transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA17363140  
GO:0005634nucleus-TAS12200431  
GO:0005654nucleoplasm-IDA-  
GO:0016514SWI/SNF complex-IDA8804307  11078522  12200431  
GO:0071564npBAF complex-ISS-  
GO:0071565nBAF complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22980975Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. (2012 Sep 14)Imielinski MCell
22975805The transcriptional landscape and mutational profile of lung adenocarcinoma. (2012 Nov)Seo JSGenome Res
28662958Targeting ATR in cancer medicine. (2017 Jul - Aug)Sundar RCurr Probl Cancer