Gene: CAPZA1

829
CAPPA1|CAPZ|CAZ1
capping actin protein of muscle Z-line subunit alpha 1
protein-coding
1p13.2
Ensembl:ENSG00000116489 MIM:601580 Vega:OTTHUMG00000011769 UniprotKB:P52907
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.737e-1 (AD)  6.768e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3790598chr1:112654274 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SSR10.92
RAB5A0.915
DDX50.913
EIF2S30.912
KDELR20.911
DCTN40.911
ARF40.907
UBE2A0.906
CD1640.906
CAP10.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.774
OR4F29-0.738
HES5-0.194
TDGF1-0.139
OR6C74-0.121
HMHB1-0.115
SPRR2A-0.115
RERGL-0.104
RNASE8-0.103
MBD3L2-0.103

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CAPZA1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CAPZA1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CAPZA1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CAPZA1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CAPZA1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CAPZA1 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of CAPZA1 mRNA"18648102
D020106AcrylamideAcrylamide results in increased expression of CAPZA1 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CAPZA1 mRNA24449571
D001241AspirinAspirin results in increased expression of CAPZA1 mRNA15928584
C006780bisphenol Abisphenol A results in decreased expression of CAPZA1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CAPZA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CAPZA1 gene28505145
C515564bromovaninbromovanin results in increased expression of CAPZA1 protein21419150
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CAPZA1 mRNA18560533
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CAPZA1 protein24527689
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CAPZA1 mRNA24763279
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CAPZA1 protein16344271
C000944dicrotophosdicrotophos results in decreased expression of CAPZA1 mRNA28302478
D004147DioxinsDioxins affects the expression of CAPZA1 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CAPZA1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAPZA1 mRNA17942748
D005411Flame RetardantsFlame Retardants results in decreased expression of CAPZA1 protein18550172
D005839GentamicinsGentamicins results in increased expression of CAPZA1 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CAPZA1 mRNA24763279
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CAPZA1 mRNA21179406
D007854LeadLead affects the expression of CAPZA1 mRNA28903495
C005095malachite greenmalachite green results in increased expression of CAPZA1 protein22446826
C008493methylselenic acidmethylselenic acid results in decreased expression of CAPZA1 mRNA18548127
D008777MethyltestosteroneMethyltestosterone results in decreased expression of CAPZA1 mRNA29191790
D015741MetriboloneMetribolone results in increased expression of CAPZA1 protein17152098
C063855microcystin RRmicrocystin RR results in decreased expression of CAPZA1 protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CAPZA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CAPZA1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of CAPZA1 mRNA19167457
D015739Nocodazole[CAPZA1 protein co-treated with CAPZA2 protein] results in decreased susceptibility to Nocodazole22918941
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CAPZA1 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CAPZA1 protein18550172
C045950propiconazolepropiconazole results in increased expression of CAPZA1 mRNA21278054
C502851quinocetonequinocetone results in decreased expression of CAPZA1 protein27046791
D012715Sesame OilSesame Oil results in increased expression of CAPZA1 mRNA29191790
D012834SilverSilver results in decreased expression of CAPZA1 mRNA27131904
D019821SimvastatinSimvastatin results in decreased expression of CAPZA1 protein20217863
C017947sodium arsenitesodium arsenite results in increased expression of CAPZA1 mRNA12377979
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAPZA1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAPZA1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAPZA1 mRNA17942748
D013806TheophyllineTheophylline results in decreased expression of CAPZA1 mRNA16083514
D013853ThioacetamideThioacetamide results in increased expression of CAPZA1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of CAPZA1 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CAPZA1 protein22595367
D014212TretinoinTretinoin results in decreased expression of CAPZA1 protein17051635
D014635Valproic AcidValproic Acid results in increased methylation of CAPZA1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CAPZA1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI22891260  23178720  
GO:0045296cadherin binding-HDA25468996  
GO:0051015actin filament binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007596blood coagulation-TAS-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0034329cell junction assembly-IMP22891260  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0045087innate immune response-TAS-  
GO:0051016barbed-end actin filament capping-IBA21873635  
GO:0051016barbed-end actin filament capping-IEA-  
GO:0065003protein-containing complex assembly-TAS9331217  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS16130169  
GO:0008290F-actin capping protein complex-IBA21873635  
GO:0008290F-actin capping protein complex-IEA-  
GO:0015629actin cytoskeleton-TAS7665558  
GO:0030479actin cortical patch-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
GO:0071203WASH complex-IDA19922875  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-109582HemostasisIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-6811436COPI-independent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-879415Advanced glycosylation endproduct receptor signalingTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9020591Interleukin-12 signalingTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal