Gene: HIST3H3

8290
H3.4|H3/g|H3FT|H3t
histone cluster 3 H3
protein-coding
1q42.13
Ensembl:ENSG00000168148 MIM:602820 Vega:OTTHUMG00000040044 UniprotKB:Q16695
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.619e-1 (AD)  8.957e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC9A40.475
C20orf1870.458
OR51F20.43
PYHIN10.429
SLAMF60.42
OR2T290.407
FAM25G0.407
FOXS10.403
FASLG0.402
ATP2A30.4

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN24-0.19
PRLHR-0.184
YIPF7-0.178
DNAI1-0.178
FSIP1-0.176
C9orf24-0.17
ASPDH-0.168
C1orf53-0.166
HRH3-0.162
SYT2-0.161

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 inhibits the reaction [IL1B protein results in increased acetylation of HIST3H3 protein]15641079
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in decreased acetylation of HIST3H3 protein]18377872
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased acetylation of HIST3H3 protein16256798
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of HIST3H3 protein"17468514
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased methylation of HIST3H3 protein"17468514
C0484603-deazaneplanocin[[3-deazaneplanocin co-treated with trichostatin A] affects the acetylation of and affects the methylation of HIST3H3 protein] which affects the expression of DACT318538736
C0067574-biphenylamine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of HIST3H3 protein"17468514
C0067574-biphenylamine4-biphenylamine results in decreased methylation of HIST3H3 protein17468514
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HIST3H3 mRNA19038236
C5036435-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin"5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin results in increased phosphorylation of HIST3H3 protein"16179969
C5036435-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin"MAPK8 protein promotes the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin results in increased phosphorylation of HIST3H3 protein]"16179969
C5036435-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin"pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin results in increased phosphorylation of HIST3H3 protein]"16179969
C5031195-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased phosphorylation of HIST3H3 protein16179969
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HIST3H3 gene27153756
C103303alitretinoin[alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [HIST3H3 protein modified form binds to TGM2 gene]15964820
C103303alitretinoinDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased acetylation of HIST3H3 protein]15964820
C029743alpha-ketoglutaric acid[[Iron co-treated with alpha-ketoglutaric acid] results in increased activity of KDM3A protein] which results in decreased methylation of HIST3H3 protein16603237
D006710HomocysteineHomocysteine promotes the reaction [HIST3H3 protein modified form binds to CCNA1 promoter]17698632
D001151Arsenic[Arsenic co-treated with Nickel] results in increased acetylation of HIST3H3 protein21385672
D001151Arsenic[Arsenic co-treated with Nickel] results in increased methylation of HIST3H3 protein21385672
D001151ArsenicArsenic results in increased methylation of HIST3H3 protein21385672
D001152ArsenicalsArsenicals affects the acetylation of HIST3H3 protein19061910
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of and results in increased acetylation of HIST3H3 protein12388546
C006632arsenic trioxidearsenic trioxide results in increased acetylation of HIST3H3 protein19679824
C015001arsenitearsenite results in increased phosphorylation of and results in increased acetylation of HIST3H3 protein11689710
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HIST3H3 mRNA"18192500
D001374AzacitidineAzacitidine promotes the reaction [HIST3H3 protein modified form binds to CCNA1 promoter]17698632
D001564Benzo(a)pyrene"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of HIST3H3 protein"17468514
D001564Benzo(a)pyreneChromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [HIST3H3 protein modified form binds to CYP1A1 promoter]]17682057
D001599BerberineBerberine results in decreased expression of HIST3H3 mRNA27311644
D001645BiguanidesBiguanides analog affects the methylation of HIST3H3 protein17463086
C006780bisphenol Abisphenol A results in increased expression of HIST3H3 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of HIST3H3 mRNA27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased methylation of HIST3H3 gene27509014
D002087ButyratesButyrates results in increased acetylation of HIST3H3 protein12130515|1547688
D002087Butyrates[Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased acetylation of HIST3H3 protein16256798
D020148Butyric AcidButyric Acid results in increased acetylation of HIST3H3 protein14576182
D002857ChromiumChromium inhibits the reaction [Benzo(a)pyrene promotes the reaction [HIST3H3 protein modified form binds to CYP1A1 promoter]]17682057
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of HIST3H3 mRNA24690739
D003474CurcuminCurcumin results in increased acetylation of HIST3H3 protein18204486
D003474CurcuminCurcumin results in increased phosphorylation of HIST3H3 protein18204486
C014347decitabine[decitabine affects the acetylation of HIST3H3 promoter] which affects the expression of IGFBP3 mRNA16505122
C014347decitabinedecitabine affects the methylation of HIST3H3 protein15959780
C014347decitabine[decitabine affects the methylation of HIST3H3 protein] which affects the methylation of CDKN2A gene18410530
C014347decitabinedecitabine affects the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C014347decitabine[decitabine co-treated with trichostatin A] affects the acetylation of HIST3H3 protein18069755
C014347decitabine[[decitabine co-treated with trichostatin A] affects the acetylation of HIST3H3 protein] which affects the expression of CDH1 mRNA18584348
C014347decitabine[decitabine co-treated with trichostatin A] affects the methylation of HIST3H3 protein15959780
C014347decitabine[decitabine co-treated with trichostatin A] affects the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C014347decitabine[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the methylation of HIST3H3 protein15959780
C014347decitabine[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [HIST3H3 protein modified form binds to RARB promoter]15959780
C014347decitabine[decitabine co-treated with trichostatin A] results in decreased methylation of HIST3H3 protein18291368
C014347decitabine[decitabine co-treated with Valproic Acid] results in decreased methylation of HIST3H3 protein19030781
C014347decitabinedecitabine promotes the reaction [HIST3H3 protein binds to MGMT promoter]15657354
C014347decitabinedecitabine results in decreased methylation of HIST3H318676679
C014347decitabinedecitabine results in decreased methylation of HIST3H3 protein18291368|1903078
C014347decitabine[Valproic Acid co-treated with decitabine] results in increased acetylation of HIST3H3 protein19030781
C014347decitabinedecitabine promotes the reaction [HIST3H3 protein modified form binds to RHOX5 promoter]19679824
C014347decitabinedecitabine results in increased acetylation of HIST3H3 protein19109157|1967982
C014347decitabinedecitabine promotes the reaction [HIST3H3 protein modified form binds to HBE1 promoter]17696208
C014347decitabinedecitabine promotes the reaction [HIST3H3 protein modified form binds to HBG1 promoter]17696208
C014347decitabinedecitabine promotes the reaction [HIST3H3 protein modified form binds to HBG2 promoter]17696208
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HIST3H3 mRNA15766596
D004121Dimethyl Sulfoxide[alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [HIST3H3 protein modified form binds to TGM2 gene]15964820
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [alitretinoin results in increased acetylation of HIST3H3 protein]15964820
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased methylation of HIST3H3 protein15964820
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of HIST3H3 mRNA24690739
C118739entinostat[fludarabine co-treated with entinostat] results in increased acetylation of HIST3H3 protein15059916
C118739entinostatentinostat promotes the reaction [HIST3H3 protein modified form binds to RHOX5 promoter]19679824
C118739entinostatentinostat results in increased acetylation of HIST3H3 protein19679824
C024352fludarabine[fludarabine co-treated with entinostat] results in increased acetylation of HIST3H3 protein15059916
C039281furanfuran results in decreased acetylation of HIST3H3 protein25539665
C039281furanfuran results in decreased methylation of HIST3H3 protein25539665
D005688GalactosamineGalactosamine results in increased expression of HIST3H3 mRNA11779202
D019833GenisteinGenistein inhibits the reaction [HIST3H3 protein modified form binds to CYLD promoter]18431742
D019833GenisteinGenistein inhibits the reaction [HIST3H3 protein modified form binds to FOXO3 promoter]18431742
D019833GenisteinGenistein inhibits the reaction [HIST3H3 protein modified form binds to PTEN promoter]18431742
D019833GenisteinGenistein inhibits the reaction [HIST3H3 protein modified form binds to TP53 promoter]18431742
D019833Genistein[Genistein results in decreased activity of SIRT1 protein] which results in decreased acetylation of HIST3H3 protein18431742
D019833GenisteinGenistein results in increased expression of HIST3H3 protein modified form19221000
D005947GlucoseGlucose promotes the reaction [HIST3H3 protein modified form binds to PKLR promoter]16644726
D006861Hydrogen PeroxideGPX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased acetylation of HIST3H3 protein]18560803
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased acetylation of HIST3H3 protein18560803
D007501Iron[[Iron co-treated with alpha-ketoglutaric acid] results in increased activity of KDM3A protein] which results in decreased methylation of HIST3H3 protein16603237
D007501IronIron results in increased methylation of HIST3H3 protein21385672
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HIST3H3 mRNA11779202
C013598methoxyacetic acidmethoxyacetic acid results in increased acetylation of HIST3H3 protein18199887
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of HIST3H3 protein24675778
C523184mocetinostatmocetinostat results in increased acetylation of HIST3H3 protein19215824
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ALDH7A1 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of AMOT promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of BRD1 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of BRINP1 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of C1QTNF6 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of CH25H promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of CPA2 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ERBB4 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of EYA4 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of FAM83A promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of FGF5 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of G0S2 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of GDF15 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of GGA3 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of GSTM4 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of HIST1H4F promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of IFITM2 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of IL11RA promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ISG15 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of KCNK10 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of KLRF1 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of KRT7 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of LHPP promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of LRRC6 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of NEFL promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of OSCAR promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of PCDHGB2 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of PKD2L2 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of PRTFDC1 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of PSMB9 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of RAPGEF5 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of RNF32 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of RSAD2 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of SLC52A3 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of SPARC promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of STARD10 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of SYT5 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of TGFB1 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of THEM4 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of TRPM4 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of TSPAN7 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of TSSC4 promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of WBP1L promoter18448484
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ZSCAN12 promoter18448484
D009532NickelNickel results in increased methylation of HIST3H3 protein16648469
D009532Nickel[Arsenic co-treated with Nickel] results in increased acetylation of HIST3H3 protein21385672
D009532Nickel[Arsenic co-treated with Nickel] results in increased methylation of HIST3H3 protein21385672
D009532NickelNickel results in increased methylation of HIST3H3 protein16648469|2138567
C022838nickel chloridenickel chloride results in decreased acetylation of HIST3H3 protein16522665
C022838nickel chloridenickel chloride results in increased methylation of HIST3H3 protein16522665|1937162
C029938nickel sulfatenickel sulfate results in increased methylation of HIST3H3 protein19371620
C029938nickel sulfatenickel sulfate results in increased methylation of HIST3H3 protein19371620
C496932panobinostatpanobinostat results in increased acetylation of HIST3H3 protein19215824
D011073PolyaminesPolyamines analog affects the methylation of HIST3H3 protein17463086|1993428
D011073PolyaminesPolyamines analog results in increased methylation of HIST3H3 protein19934284
C027373potassium chromate(VI)potassium chromate(VI) results in increased methylation of HIST3H3 protein19371620
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin results in increased phosphorylation of HIST3H3 protein]"16179969
D011794Quercetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in decreased acetylation of HIST3H3 protein]18377872
D011794QuercetinQuercetin results in decreased acetylation of HIST3H3 protein18377872
C087123romidepsinromidepsin results in increased acetylation of HIST3H3 protein16006969
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HIST3H3 mRNA25895662
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ALDH7A1 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of AMOT promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of BRD1 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of BRINP1 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of C1QTNF6 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of CH25H promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of CPA2 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ERBB4 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of EYA4 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of FAM83A promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of FGF5 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of G0S2 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of GDF15 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of GGA3 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of GSTM4 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of HIST1H4F promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of IFITM2 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of IL11RA promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ISG15 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of KCNK10 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of KLRF1 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of KRT7 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of LHPP promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of LRRC6 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of NEFL promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of OSCAR promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of PCDHGB2 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of PKD2L2 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of PRTFDC1 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of PSMB9 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of RAPGEF5 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of RNF32 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of RSAD2 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of SLC52A3 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of SPARC promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of STARD10 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of SYT5 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of TGFB1 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of THEM4 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of TRPM4 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of TSPAN7 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of TSSC4 promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of WBP1L promoter18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ZSCAN12 promoter18448484
C017947sodium arsenitesodium arsenite results in decreased methylation of HIST3H3 protein19371620
C017947sodium arsenitesodium arsenite results in increased methylation of HIST3H3 protein19371620
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased acetylation of HIST3H3 protein12547826
C017947sodium arsenitesodium arsenite results in increased phosphorylation of HIST3H3 protein15327774
D018038Sodium SeleniteSodium Selenite affects the reaction [HIST3H3 protein modified form binds to GSTP1 promoter]18676679
D018038Sodium SeleniteSodium Selenite results in decreased methylation of HIST3H318676679
D018038Sodium SeleniteSodium Selenite results in increased acetylation of HIST3H318676679
D013749Tetrachlorodibenzodioxin"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of HIST3H3 protein"17468514
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased acetylation of HIST3H3 protein15964790
D014212Tretinoin[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the methylation of HIST3H3 protein15959780
D014212Tretinoin[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [HIST3H3 protein modified form binds to RARB promoter]15959780
D014212TretinoinTretinoin results in increased acetylation of HIST3H3 protein16613989
D014212TretinoinTretinoin promotes the reaction [[HIST3H3 protein modified form binds to CBX1 protein] which binds to POU5F1 promoter]16415856
D014212TretinoinTretinoin promotes the reaction [[HIST3H3 protein modified form binds to CBX1 protein] which binds to ZFP42 promoter]16415856
D014212TretinoinTretinoin results in decreased acetylation of HIST3H3 protein16415856
D014212TretinoinTretinoin results in increased acetylation of HIST3H3 protein16845368
D014212TretinoinTretinoin results in increased methylation of HIST3H3 gene16415856
C012589trichostatin A[[3-deazaneplanocin co-treated with trichostatin A] affects the acetylation of and affects the methylation of HIST3H3 protein] which affects the expression of DACT318538736
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the acetylation of HIST3H3 protein18069755
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the acetylation of HIST3H3 protein] which affects the expression of CDH1 mRNA18584348
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the methylation of HIST3H3 protein15959780
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C012589trichostatin A[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the methylation of HIST3H3 protein15959780
C012589trichostatin A[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [HIST3H3 protein modified form binds to RARB promoter]15959780
C012589trichostatin A[decitabine co-treated with trichostatin A] results in decreased methylation of HIST3H3 protein18291368
C012589trichostatin A[trichostatin A affects the acetylation of HIST3H3 promoter] which affects the expression of IGFBP3 mRNA16505122
C012589trichostatin A[trichostatin A affects the acetylation of HIST3H3 protein] which affects the expression of CDH1 mRNA18584348
C012589trichostatin Atrichostatin A promotes the reaction [HIST3H3 protein modified form binds to CCNA1 promoter]17698632
C012589trichostatin Atrichostatin A promotes the reaction [HIST3H3 protein modified form binds to PTEN promoter]17330857
C012589trichostatin Atrichostatin A promotes the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C012589trichostatin Atrichostatin A results in decreased methylation of HIST3H3 protein18291368
C012589trichostatin Atrichostatin A results in increased acetylation of HIST3H318676679
C012589trichostatin Atrichostatin A results in increased acetylation of HIST3H3 protein15959780|1674072
C012589trichostatin Atrichostatin A results in increased acetylation of HIST3H3 protein11689710
D014635Valproic Acid[decitabine co-treated with Valproic Acid] results in decreased methylation of HIST3H3 protein19030781
D014635Valproic Acid[Valproic Acid co-treated with decitabine] results in increased acetylation of HIST3H3 protein19030781
D014635Valproic AcidValproic Acid results in increased acetylation of HIST3H3 protein14576182|1903078
D014635Valproic AcidValproic Acid results in increased methylation of HIST3H3 gene29154799
D014635Valproic AcidValproic Acid results in increased acylation of HIST3H3 protein15737665
D014801Vitamin AVitamin A affects the reaction [HIST3H3 protein modified form binds to PCK1 promoter]16317119
D014801Vitamin AVitamin A results in increased acetylation of HIST3H3 protein16317119
C111237vorinostatvorinostat results in increased acetylation of HIST3H3 protein17431121

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17537733  17567753  17599839  20224553  20498094  29340707  
GO:0031492nucleosomal DNA binding-IBA21873635  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006334nucleosome assembly-IBA21873635  
GO:0006334nucleosome assembly-IDA25615412  
GO:0006334nucleosome assembly-IMP20498094  
GO:0016233telomere capping-TAS-  
GO:0032460negative regulation of protein oligomerization-IMP20498094  
GO:0051290protein heterotetramerization-IDA20498094  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000786nucleosome-IBA21873635  
GO:0000786nucleosome-IDA25615412  
GO:0000788nuclear nucleosome-IDA20498094  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-157579Telomere MaintenanceTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-171306Packaging Of Telomere EndsTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexIEA
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2299718Condensation of Prophase ChromosomesTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-73894DNA RepairTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19038236Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2009 Feb 12)Prokopczyk BChem Biol Interact