Gene: COLQ

8292
CMS5|EAD
collagen like tail subunit of asymmetric acetylcholinesterase
protein-coding
3p25.1
Ensembl:ENSG00000206561 MIM:603033 Vega:OTTHUMG00000156233 UniprotKB:Q9Y215
NG_009032.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.195e-1 (AD)  6.892e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12495710chr3:15517721 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF1330.88
SRRM30.855
CENPT0.852
ANKRD13B0.848
ZFR20.847
UBAP1L0.846
NEIL10.843
BRICD50.838
CORO60.837
CES4A0.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.434
OR4F5-0.415
C9orf135-0.402
OR4F29-0.389
AGTR1-0.363
YES1-0.363
SIX2-0.358
ELK3-0.357
WWTR1-0.356
PABPC4L-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of COLQ mRNA"26377693
C5254852-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole results in increased expression of COLQ mRNA"27665778
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of COLQ mRNA25088246
D000082AcetaminophenAcetaminophen results in decreased expression of COLQ mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of COLQ mRNA]22129741
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of COLQ mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of COLQ gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of COLQ mRNA16483693
C095105bexarotenebexarotene results in increased expression of COLQ mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of COLQ mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of COLQ mRNA26079696
D002994ClofibrateClofibrate results in increased expression of COLQ mRNA27665778
D003471CuprizoneCuprizone results in increased expression of COLQ mRNA27523638
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of COLQ mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of COLQ mRNA27392435
D002945CisplatinCisplatin results in decreased expression of COLQ mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of COLQ mRNA25016146
D004052DiethylnitrosamineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of COLQ mRNA]22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of COLQ mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of COLQ mRNA22129741
D011345FenofibrateFenofibrate results in increased expression of COLQ mRNA27665778
D018120FinasterideFinasteride results in increased expression of COLQ mRNA24136188
D005485FlutamideFlutamide results in decreased expression of COLQ mRNA24136188
D015248GemfibrozilGemfibrozil results in increased expression of COLQ mRNA27665778
C016517indole-3-carbinolAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of COLQ mRNA]22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of COLQ mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of COLQ mRNA22129741
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of COLQ mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of COLQ mRNA16807920
C011890kojic acidkojic acid results in increased expression of COLQ mRNA16595896
D007840LatexLatex analog results in increased expression of COLQ mRNA24768652
C500085muraglitazarmuraglitazar results in increased expression of COLQ mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of COLQ mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of COLQ mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of COLQ mRNA27935865
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of COLQ mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of COLQ mRNA19162173|2851185
C071927perlecanCOLQ protein binds to perlecan22981737
C006253pirinixic acidpirinixic acid results in increased expression of COLQ mRNA19162173|2248451
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of COLQ mRNA21334430
D011441PropylthiouracilPropylthiouracil results in increased expression of COLQ mRNA24780913
C089730rosiglitazonerosiglitazone results in increased expression of COLQ mRNA21515302
D053260SootSoot results in decreased expression of COLQ mRNA26551751
C501413tesaglitazartesaglitazar results in increased expression of COLQ mRNA21515302
D014241TrichloroethyleneTrichloroethylene results in increased methylation of COLQ gene27618143
C057693troglitazonetroglitazone results in increased expression of COLQ mRNA21515302
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of COLQ mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0005515protein binding-IPI15526038  
GO:0008201heparin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001507acetylcholine catabolic process in synaptic cleft-TAS9689136  
GO:0008582regulation of synaptic growth at neuromuscular junction-IEA-  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0071340skeletal muscle acetylcholine-gated channel clustering-IEA-  
GO:0090150establishment of protein localization to membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005581collagen trimer-IEA-  
GO:0005605basal lamina-TAS9689136  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-TAS9689136  
GO:0005886plasma membrane-IDA-  
GO:0030054cell junction-IDA-  
GO:0031594neuromuscular junction-IEA-  
GO:0043083synaptic cleft-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal