Gene: PICALM

8301
CALM|CLTH|LAP
phosphatidylinositol binding clathrin assembly protein
protein-coding
11q14.2
Ensembl:ENSG00000073921 MIM:603025 Vega:OTTHUMG00000166981 UniprotKB:Q13492
NG_028942.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.736e-1 (AD)  1.032e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX50.917
UBXN40.915
ADAM100.913
CD1640.911
SCARB20.908
SNX90.899
SF3B10.898
SRSF10.897
PRPF4B0.896
GPBP1L10.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.731
OR4F5-0.73
HES5-0.256
GOLGA6L1-0.152
WNT7B-0.144
ARSF-0.14
PLA2G5-0.131
OR2A2-0.125
SPANXA2-0.123
NXNL1-0.116

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PICALM mRNA"21354444|2269881
C0326681-nitropyrene1-nitropyrene results in increased expression of PICALM mRNA19041380
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PICALM mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PICALM mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PICALM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PICALM mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PICALM mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PICALM mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PICALM mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PICALM mRNA25339124
D001241AspirinAspirin results in decreased expression of PICALM mRNA11906190
D001280AtrazineAtrazine results in decreased expression of PICALM mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PICALM mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PICALM mRNA"19150397
D004958EstradiolEstradiol affects the expression of PICALM mRNA22574217
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PICALM mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PICALM mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PICALM mRNA20678512|2927551
C006780bisphenol Abisphenol A affects the expression of PICALM mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of PICALM protein28903499
C584509C646 compoundC646 compound results in decreased expression of PICALM mRNA26191083
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of PICALM protein"23026733
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PICALM mRNA27339419
C054133casticincasticin results in decreased expression of PICALM mRNA28444820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PICALM mRNA23650126
D002994ClofibrateClofibrate results in increased expression of PICALM mRNA23811191
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PICALM mRNA17602206
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PICALM mRNA15467011
D003300CopperMT1 affects the reaction [Copper results in increased expression of PICALM mRNA]16629173
D003300CopperMT2 affects the reaction [Copper results in increased expression of PICALM mRNA]16629173
D003375CoumestrolCoumestrol results in decreased expression of PICALM mRNA19167446
C030973cupric oxidecupric oxide results in increased expression of PICALM protein25470785
D003471CuprizoneCuprizone results in increased expression of PICALM mRNA27523638
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PICALM mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PICALM mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PICALM mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PICALM mRNA17602206
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of PICALM mRNA17374397
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PICALM protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PICALM mRNA22079256
D005054EugenolEugenol results in increased expression of PICALM mRNA17374397
D005839GentamicinsGentamicins results in increased expression of PICALM mRNA22061828
D006220HaloperidolHaloperidol results in decreased expression of PICALM mRNA15860345
D017313FenretinideFenretinide results in increased expression of PICALM mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PICALM protein18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PICALM mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PICALM mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of PICALM mRNA20003209
C544151jinfukangjinfukang results in decreased expression of PICALM mRNA27392435
C410337K 7174K 7174 results in increased expression of PICALM mRNA24086573
C008261lead acetatelead acetate affects the expression of PICALM mRNA21147602
C045463leflunomideleflunomide results in decreased expression of PICALM mRNA19751817
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PICALM protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PICALM mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PICALM mRNA"27188386
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of PICALM protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PICALM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PICALM mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of PICALM mRNA16780908|1737439
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PICALM mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of PICALM mRNA18301758|1844570
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PICALM mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PICALM mRNA22079256
C045950propiconazolepropiconazole results in increased expression of PICALM mRNA21278054
D012999SomanSoman results in increased expression of PICALM mRNA19281266
C004648testosterone enanthatetestosterone enanthate affects the expression of PICALM mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PICALM mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PICALM mRNA28213091
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of PICALM protein20109541
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PICALM protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PICALM mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PICALM mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PICALM mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of PICALM mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of PICALM mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16491119  22829078  23382074  
GO:00055451-phosphatidylinositol binding-ISS-  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-ISS25898166  
GO:0017137Rab GTPase binding-IPI26005850  
GO:0030276clathrin binding-IDA10436022  16262731  
GO:0030276clathrin binding-IPI23589030  
GO:0030276clathrin binding-ISS-  
GO:0032050clathrin heavy chain binding-IDA10436022  
GO:0035615clathrin adaptor activity-IMP23589030  
GO:0045296cadherin binding-HDA25468996  
GO:0050750low-density lipoprotein particle receptor binding-IPI26005850  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-IDA10436022  
GO:0006898receptor-mediated endocytosis-ISS-  
GO:0007409axonogenesis-IEA-  
GO:0007611learning or memory-ISS26005850  
GO:0008283cell proliferation-IMP22952941  
GO:0010629negative regulation of gene expression-IMP22952941  
GO:0016050vesicle organization-IMP25898166  
GO:0016188synaptic vesicle maturation-ISS-  
GO:0016192vesicle-mediated transport-TAS8643484  
GO:0016197endosomal transport-IMP16262731  
GO:0030097hemopoiesis-IEA-  
GO:0030100regulation of endocytosis-IMP18182011  
GO:0031623receptor internalization-IMP14985334  25898166  
GO:0032880regulation of protein localization-IDA10436022  
GO:0035459cargo loading into vesicle-IMP24577224  
GO:0043547positive regulation of GTPase activity-IMP26005850  
GO:0045056transcytosis-IMP26005850  
GO:0045893positive regulation of transcription, DNA-templated-IDA11425879  
GO:0048261negative regulation of receptor-mediated endocytosis-IDA10436022  
GO:0048268clathrin coat assembly-IMP16262731  
GO:0048813dendrite morphogenesis-IEA-  
GO:0055072iron ion homeostasis-IMP22952941  
GO:0061024membrane organization-TAS-  
GO:0065003protein-containing complex assembly-TAS8643484  
GO:0072583clathrin-dependent endocytosis-IMP22952941  24577224  26005850  
GO:0090647modulation of age-related behavioral decline-ISS26005850  
GO:0097494regulation of vesicle size-IMP25898166  
GO:0097753membrane bending-IMP25898166  
GO:0098711iron ion import across plasma membrane-IMP22952941  
GO:1900223positive regulation of amyloid-beta clearance-ISS26005850  
GO:1901216positive regulation of neuron death-IMP23589030  
GO:1902003regulation of amyloid-beta formationNOTISS26005850  
GO:1902004positive regulation of amyloid-beta formation-IMP24577224  
GO:1902004positive regulation of amyloid-beta formation-TAS26005850  
GO:1902959regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-IMP24577224  
GO:1902961positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-ISS-  
GO:1902963negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process-ISS-  
GO:1903077negative regulation of protein localization to plasma membrane-IMP21221849  
GO:2000009negative regulation of protein localization to cell surface-IMP21221849  
GO:2000370positive regulation of clathrin-dependent endocytosis-NAS25898166  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16491119  
GO:0005769early endosome-IDA26005850  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005905clathrin-coated pit-IDA10436022  
GO:0005905clathrin-coated pit-IMP25898166  
GO:0005905clathrin-coated pit-ISS-  
GO:0009986cell surface-IDA26005850  
GO:0016020membrane-HDA19946888  
GO:0030122AP-2 adaptor complexcolocalizes_withIDA16262731  
GO:0030132clathrin coat of coated pitcolocalizes_withIDA10436022  16262731  
GO:0030136clathrin-coated vesicle-IMP25898166  
GO:0031224intrinsic component of membrane-ISS25898166  
GO:0031982vesicle-ISS-  
GO:0042734presynaptic membrane-ISS-  
GO:0043025neuronal cell body-IDA23589030  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045211postsynaptic membrane-ISS-  
GO:0045334clathrin-coated endocytic vesicle-NAS25898166  
GO:0048471perinuclear region of cytoplasmcolocalizes_withISS-  
GO:0070381endosome to plasma membrane transport vesicle-IDA26005850  
GO:0097418neurofibrillary tangle-IMP23589030  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
21912625An exploratory study on CLU, CR1 and PICALM and Parkinson disease. (2011)Gao JPLoS One