Gene: CAST

831
BS-17|PLACK
calpastatin
protein-coding
5q15
Ensembl:ENSG00000153113 MIM:114090 Vega:OTTHUMG00000128413 UniprotKB:P20810
NG_029490.1
PubMed|SNP Mapped
1   ANCO-SNPs
CD|OD|ND|AD
23   
5.171e-1 (AD)  6.154e-1 (ND)   (Frontal_Cortex)
1.615e-1 (AD)  4.305e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13362120chr5:96735490 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PICALM0.879
PRPF4B0.875
NUP2050.865
CNOT80.863
XRN20.862
COPB10.862
ERP440.861
DHX150.86
CD1640.858
BIRC20.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.565
OR4F5-0.564
HES5-0.392
BTBD17-0.32
ARSF-0.31
REN-0.259
PLA2G5-0.253
NXNL1-0.252
MMD2-0.241
SLC13A5-0.236

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01373CalciumSmall Molecule7440-70-2Approved|NutraceuticalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CAST mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CAST mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CAST mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CAST mRNA"21346803
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of CAST mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAST mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAST mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CAST mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAST mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CAST mRNA17562736
D000082AcetaminophenCAST protein inhibits the reaction [Acetaminophen results in increased degradation of SPTAN1 protein]16871587
D000082AcetaminophenCAST protein results in decreased susceptibility to Acetaminophen16871587
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CAST gene27153756
C038491allyl sulfideallyl sulfide results in decreased expression of CAST mRNA17647244
C038491allyl sulfideallyl sulfide results in decreased expression of CAST protein17647244
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CAST mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in increased expression of CAST mRNA15372504
C547126AZM551248AZM551248 results in decreased expression of CAST mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CAST mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CAST mRNA"26238291
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CAST mRNA20823114
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of CAST mRNA25912373
C006780bisphenol Abisphenol A affects the expression of CAST mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CAST mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CAST gene28505145
D001761BleomycinBleomycin results in increased expression of CAST protein25933445
C013418bromfenacoumbromfenacoum results in decreased expression of CAST protein28903499
D002083Butylated HydroxyanisoleButylated Hydroxyanisole promotes the reaction [CAST results in decreased susceptibility to Cadmium Chloride]17323976
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CAST mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of CAST mRNA26079696
D019256Cadmium ChlorideButylated Hydroxyanisole promotes the reaction [CAST results in decreased susceptibility to Cadmium Chloride]17323976
D019256Cadmium ChlorideCAST results in decreased susceptibility to Cadmium Chloride17323976
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CAST mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CAST mRNA16871587
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CAST protein16871587
D002273CarcinogensCarcinogens results in decreased expression of CAST mRNA22269147
D002713ChlorineChlorine results in increased expression of CAST mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of CAST mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CAST mRNA23650126
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CAST mRNA"19167446
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CAST mRNA17654400
D016572CyclosporineCyclosporine results in increased expression of CAST mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of CAST mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CAST mRNA24317228
C028009diallyl disulfidediallyl disulfide results in decreased expression of CAST mRNA17647244
C028009diallyl disulfidediallyl disulfide results in decreased expression of CAST protein17647244
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CAST mRNA20823114
D002945CisplatinCisplatin results in increased expression of CAST mRNA27392435
D002945CisplatinCisplatin results in increased expression of CAST mRNA21151649
C039060dihydroartemisinindihydroartemisinin analog binds to CAST protein modified form26340163
D004237DiuronDiuron results in decreased expression of CAST mRNA25152437
C118739entinostatentinostat results in decreased expression of CAST mRNA26272509
C118739entinostatentinostat results in increased expression of CAST mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CAST protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CAST mRNA23649840
D005047EtoposideCAST inhibits the reaction [Etoposide results in increased degradation of AR protein]18726991
D018120FinasterideFinasteride results in increased expression of CAST mRNA24136188
D005485FlutamideFlutamide results in increased expression of CAST mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of CAST mRNA23649840
D005839GentamicinsGentamicins results in increased expression of CAST mRNA22061828
D017313FenretinideFenretinide results in decreased expression of CAST mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CAST mRNA20044591
D007213IndomethacinIndomethacin results in decreased expression of CAST mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CAST mRNA23086925
D001556LindaneLindane results in increased expression of CAST mRNA17785943
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CAST mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides affects the expression of CAST mRNA21127968
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CAST mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CAST mRNA26378955
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CAST mRNA20823114
D008627Mercuric ChlorideMercuric Chloride affects the expression of CAST mRNA20353558
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to CAST promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CAST mRNA23179753|2718838
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CAST mRNA"26251327
C008493methylselenic acidmethylselenic acid results in increased expression of CAST mRNA18548127
C523799MRK 003MRK 003 results in decreased expression of CAST mRNA21169257
D009153MutagensMutagens results in decreased expression of CAST mRNA22269147
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CAST mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CAST mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CAST mRNA"25554681
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of CAST mRNA18636392
C016030pantogabpantogab results in increased expression of CAST mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of CAST mRNA22178795
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CAST mRNA18692542
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAST mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CAST mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CAST mRNA19162173
D010894PiroxicamPiroxicam results in increased expression of CAST mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in increased expression of CAST protein23718831
D012715Sesame OilSesame Oil results in increased expression of CAST mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CAST mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of CAST mRNA12016162
D013148SpironolactoneSpironolactone results in increased expression of CAST protein20082611
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CAST mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CAST mRNA26378955
D013467SulindacSulindac results in decreased expression of CAST mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CAST protein16548065
C012589trichostatin Atrichostatin A results in increased expression of CAST mRNA24935251
C050414tripterineCAST inhibits the reaction [tripterine results in increased degradation of AR protein]18726991
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of CAST mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CAST mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CAST mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CAST mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of CAST mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CAST gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IBA21873635  
GO:0003723RNA binding-HDA22658674  
GO:0004866endopeptidase inhibitor activity-TAS7638179  
GO:0005515protein binding-IPI17474147  24462690  
GO:0010859calcium-dependent cysteine-type endopeptidase inhibitor activity-IBA21873635  
GO:0010859calcium-dependent cysteine-type endopeptidase inhibitor activity-IMP2407243  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0097340inhibition of cysteine-type endopeptidase activity-IBA21873635  
GO:0097340inhibition of cysteine-type endopeptidase activity-IMP2407243  
GO:1990709presynaptic active zone organization-TAS27626661  
GO:2000675negative regulation of type B pancreatic cell apoptotic process-IDA15044459  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005829cytosol-IDA14559243  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IBA21873635  
GO:0016020membrane-IDA14559243  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1643685DiseaseTAS
R-HSA-1643685DiseaseIEA
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsTAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsIEA
R-HSA-8863678Neurodegenerative DiseasesTAS
R-HSA-8863678Neurodegenerative DiseasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12635093The role of carotenoids on the risk of lung cancer. (2003 Feb)Epstein KRSemin Oncol
18053732The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters. (2008 Feb 15)Meltzer PCBioorg Med Chem
28534175[Aseptic loosening of total ankle replacement : Two-stage revision with bone augmentation of osseous defects and secondary prosthesis implantation]. (2017 Jun)Barg AOper Orthop Traumatol
25990808Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years. (2015 May 20)Paaso AJ Transl Med
19932800Another look at the results of the JUPITER trial. (2009 Dec 1)Kappagoda CTAm J Cardiol
27145822Antibodies to carbamylated alpha-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies. (2016 May 4)Reed EArthritis Res Ther
8004452The CCKA receptor antagonist devazepide does not modify opioid self-administration or drug discrimination: comparison with the dopamine antagonist haloperidol. (1994 Mar 21)Higgins GABrain Res
24809844Role of glutathione S transferase polymorphism in COPD with special reference to peoples living in the vicinity of the open cast coal mine of Assam. (2014)Dey TPLoS One
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res
15705463The p53 tumour suppressor gene and the tobacco industry: research, debate, and conflict of interest. (2005 Feb 5-11)Bitton ALancet
22075204Alexithymia in relation to parental alcoholism, everyday frontal lobe functioning and alcohol consumption in a non-clinical sample. (2012 Feb)Lyvers MAddict Behav
22063434The interaction between calpastatin and RYR1 genes for some pork quality traits. (2003 Oct)Kocwin-Podsiadla MMeat Sci
25472491Unemployment and substance use in young adults: does educational attainment modify the association? (2015)Melchior MEur Addict Res
1465752Relation of serum elastin peptide concentration to age, FEV1, smoking habits, alcohol consumption, and protease inhibitor phenotype: an epidemiological study in working men. (1992 Nov)Frette CThorax
28560653Association of Single Nucleotide Polymorphisms in XRCC1 (194) and XPD (751) with Age-related cataract. (2017 May 30)Khosa TInt Ophthalmol
23486516Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction. (2013 Jul)van Slambrouck CMKidney Int
27193106Prognostic Factors for Morbimortality in Sleeve Gastrectomy. The Importance of the Learning Curve. A Spanish-Portuguese Multicenter Study. (2016 Dec)Sanchez-Santos RObes Surg
26018725[Percutaneous screw fixation of non- or minimally displaced scaphoid fractures]. (2015 Oct)Neshkova ISOper Orthop Traumatol
26199034[Dwyer osteotomy : Lateral sliding osteotomy of calcaneus]. (2015 Aug)Barg AOper Orthop Traumatol
15528021Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. (2004 Dec)Ellis IGastroenterol Clin North Am
16980331The U.S. Public Health Service and smoking in the 1950s: the tale of two more statements. (2007 Apr)Harkness JMJ Hist Med Allied Sci
28497248[Aseptic loosening of total ankle replacement : One-stage revision ankle arthroplasty]. (2017 Jun)Pagenstert GOper Orthop Traumatol
24102987Regional anesthesia does not consistently block ischemic pain: two further cases and a review of the literature. (2014 Feb)Kucera TJPain Med