Gene info: ID 8312

Gene: AXIN1

GENE ID: 8312

Synonyms: AXIN|PPP1R49

Description: axin 1

Gene type: protein-coding

Location: 16p13.3

dbXrefs: Ensembl:ENSG00000103126 MIM:603816 Vega:OTTHUMG00000064930 UniprotKB:O15169

RefSeq: NG_012267.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.717e-1 (AD) 1.742e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg06387245	chr16:348076	AXIN1	Gene body	1.817e-4	Alcohol use disorders	26763658
cg07915516	chr16:377344	AXIN1	Gene body	2.214e-4	Alcohol use disorders	26763658
cg03660377	chr16:368048	AXIN1		3.600e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PIAS4	0.874
DAXX	0.854
GPS2	0.853
STX10	0.85
ZNF768	0.849
RILPL1	0.847
SGTA	0.843
CXXC1	0.843
DAZAP1	0.84
MAP2K7	0.839

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.661
OR4F5	-0.645
C10orf71	-0.293
CD36	-0.288
XIRP2	-0.279
FER1L6	-0.273
TBX4	-0.271
FMO1	-0.266
LMOD2	-0.263
AMPD1	-0.261

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04447	1,4-Dithiothreitol	Small Molecule	3483-12-3	Experimental	Target

ID	Drug Name	Action	PubMed
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of AXIN1 mRNA"	20826375
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AXIN1 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of AXIN1 mRNA"	21346803
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein]	19407222
D000082	Acetaminophen	Acetaminophen results in increased expression of AXIN1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of AXIN1 mRNA	17562736
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein]	19407222
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of AXIN1 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of AXIN1 gene	25304211
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AXIN1 mRNA"	19150397
D004958	Estradiol	Estradiol results in increased expression of AXIN1 mRNA	20826375
D001622	Betaine	[Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene	16868943
C044887	beta-methylcholine	beta-methylcholine affects the expression of AXIN1 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of AXIN1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of AXIN1 mRNA	20826375
C006780	bisphenol A	bisphenol A affects the expression of AXIN1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of AXIN1 mRNA	25963729
C006780	bisphenol A	bisphenol A results in increased expression of AXIN1 mRNA	25181051
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]	25963729
C584509	C646 compound	C646 compound results in increased expression of AXIN1 mRNA	26921506
D002118	Calcium	Calcium affects the expression of AXIN1 mRNA	15913539
D002794	Choline	[Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene	16868943
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]	25963729
D003474	Curcumin	Curcumin results in increased expression of AXIN1 mRNA	25963729
D016572	Cyclosporine	Cyclosporine results in increased expression of AXIN1 mRNA	25562108
C014347	decitabine	decitabine results in increased expression of AXIN1 mRNA	27915011
D003976	Diazinon	Diazinon results in increased methylation of AXIN1 gene	22964155
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in decreased expression of AXIN1 mRNA"	16269432
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of AXIN1 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of AXIN1 mRNA	27392435
D004147	Dioxins	Dioxins affects the expression of AXIN1 mRNA	20463971
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of AXIN1 mRNA	21040762
D005013	Ethosuximide	Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]	26420483
D005013	Ethosuximide	Ethosuximide results in increased expression of AXIN1 mRNA	26420483
D005485	Flutamide	Flutamide results in increased expression of AXIN1 mRNA	24136188
D005492	Folic Acid	[Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene	16868943
D005839	Gentamicins	Gentamicins results in increased expression of AXIN1 mRNA	22061828
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of AXIN1 mRNA	26830473
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of AXIN1 mRNA	25613284
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the methylation of AXIN1 gene	28011154
D010634	Phenobarbital	Phenobarbital affects the expression of AXIN1 mRNA	19159669
D011374	Progesterone	Progesterone affects the expression of AXIN1 mRNA	17251523
D011374	Progesterone	Progesterone results in increased expression of AXIN1 mRNA	17170212
C017947	sodium arsenite	sodium arsenite affects the methylation of AXIN1 gene	28589171
D018038	Sodium Selenite	Sodium Selenite results in increased expression of AXIN1 mRNA	18175754
D012999	Soman	Soman results in increased expression of AXIN1 mRNA	19281266
C061133	tamibarotene	tamibarotene results in increased expression of AXIN1 mRNA	15498508
D014212	Tretinoin	Tretinoin results in increased expression of AXIN1 mRNA	15498508
D014635	Valproic Acid	Valproic Acid affects the expression of AXIN1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of AXIN1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of AXIN1 mRNA	19136453
D014805	Vitamin B 12	[Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene	16868943

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	9601641 10481074 10644691 11738041 12192039 16169070 16293619 16601693 17318175 17318191 17510365 17588722 17601533 18786926 19131971 19166851 19202075 19249679 19303846 19390532 19759537 20080667 21057547 21242974 21245303 21988832 22153077 22682247 22773187 23455922 23602568 24976009 25241761 25873176 26496610 26871637 27098453 27484798 29568061
GO:0008013	beta-catenin binding	-	IDA	10644691
GO:0019899	enzyme binding	-	IPI	19759537 21383061 21478859
GO:0019901	protein kinase binding	-	ISS	-
GO:0030159	receptor signaling complex scaffold activity	-	IEA	-
GO:0031625	ubiquitin protein ligase binding	-	IPI	16601693 21478859
GO:0032947	protein-containing complex scaffold activity	-	IDA	9601641
GO:0032947	protein-containing complex scaffold activity	-	IMP	16601693
GO:0035591	signaling adaptor activity	-	TAS	21799911
GO:0042802	identical protein binding	-	IPI	16169070 21245303
GO:0042802	identical protein binding	-	ISS	-
GO:0042803	protein homodimerization activity	-	ISS	-
GO:0046332	SMAD binding	-	IPI	18593713
GO:0070016	armadillo repeat domain binding	-	ISS	-
GO:0070411	I-SMAD binding	-	IPI	16601693 18593713

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IDA	9601641
GO:0006915	apoptotic process	-	IEA	-
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	-	NAS	18593713
GO:0016055	Wnt signaling pathway	-	TAS	-
GO:0030111	regulation of Wnt signaling pathway	-	TAS	-
GO:0030178	negative regulation of Wnt signaling pathway	-	IDA	10644691
GO:0031398	positive regulation of protein ubiquitination	-	NAS	18593713
GO:0032147	activation of protein kinase activity	-	IDA	9601641
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	NAS	18593713
GO:0033146	regulation of intracellular estrogen receptor signaling pathway	-	TAS	-
GO:0034622	cellular protein-containing complex assembly	-	IDA	16601693
GO:0043547	positive regulation of GTPase activity	-	IEA	-
GO:0045732	positive regulation of protein catabolic process	-	IC	16188939
GO:0045732	positive regulation of protein catabolic process	-	IDA	9601641
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	16601693
GO:0046330	positive regulation of JNK cascade	-	ISS	-
GO:0051443	positive regulation of ubiquitin-protein transferase activity	-	IMP	16601693
GO:0060070	canonical Wnt signaling pathway	-	IC	9601641
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IMP	22899650
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	-
GO:1904885	beta-catenin destruction complex assembly	-	TAS	-
GO:1904886	beta-catenin destruction complex disassembly	-	TAS	-
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	12072559 21383061
GO:0005737	cytoplasm	-	IDA	12072559 17569865 21383061
GO:0005829	cytosol	-	TAS	-
GO:0016328	lateral plasma membrane	-	IDA	12072559
GO:0030877	beta-catenin destruction complex	-	IDA	9601641 16188939 19759537
GO:0031410	cytoplasmic vesicle	-	ISS	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	19038973
GO:0071944	cell periphery	-	IDA	19038973

KEGG ID	KEGG Term
hsa04310	Wnt signaling pathway
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05213	Endometrial cancer
hsa05217	Basal cell carcinoma

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-196299	Beta-catenin phosphorylation cascade	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4641257	Degradation of AXIN	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	IEA
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	TAS
R-HSA-4791275	Signaling by WNT in cancer	TAS
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	TAS
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	TAS
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	TAS
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	TAS
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	TAS
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	TAS
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	TAS
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22207181	Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran. (2012 May)	Naghibalhossaini F	Mol Biol Rep