Gene: AXIN2

8313
AXIL|ODCRCS
axin 2
protein-coding
17q24.1
Ensembl:ENSG00000168646 MIM:604025 Vega:OTTHUMG00000179353 UniprotKB:Q9Y2T1
NG_012142.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.613e-1 (AD)  7.209e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNRNP2000.835
CTNND10.829
ATP8B20.824
PIAS30.82
ZZEF10.814
GON4L0.814
SUN10.802
FAM160B20.799
SETD1B0.798
TSPAN140.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.532
OR4F29-0.522
KLRC2-0.288
IRX2-0.284
ODAM-0.28
C9orf92-0.277
CTNNA3-0.269
ANXA13-0.268
HCRT-0.265
CRNDE-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [TGFB1 protein promotes the reaction [NR4A1 protein binds to AXIN2 protein]]"26929200
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of AXIN2 protein"21705713
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of AXIN2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of AXIN2 mRNA19933214
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [WNT3A results in increased expression of AXIN2 protein]"19464575
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of AXIN2 mRNA"19464575
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter analog results in decreased expression of AXIN2 mRNA]27216425
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with kenpaullone] results in increased expression of AXIN2 mRNA"25711857
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with XAV939] results in increased expression of AXIN2 mRNA"25711857
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AXIN2 mRNA"25711857
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AXIN2 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"AHR2 protein affects the reaction [[kenpaullone co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of AXIN2 mRNA]"25711857
C1118556-formylindolo(3,2-b)carbazole"[AHR2 protein co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of AXIN2 mRNA"25711857
C1118556-formylindolo(3,2-b)carbazole"[kenpaullone co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of AXIN2 mRNA"25711857
C1118556-formylindolo(3,2-b)carbazole"[XAV939 co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of AXIN2 mRNA"25711857
D000079AcetaldehydeAcetaldehyde affects the expression of AXIN2 mRNA22634333
C042151aeroplysinin Iaeroplysinin I results in decreased expression of AXIN2 protein27120392
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of AXIN2 mRNA"19936710
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AXIN2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AXIN2 mRNA24449571
C015001arsenitearsenite results in increased methylation of AXIN2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AXIN2 mRNA26238291
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of AXIN2 mRNA]24758408
D004958EstradiolEstradiol affects the expression of AXIN2 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of AXIN2 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of AXIN2 mRNA24758408
D001663BilirubinBilirubin results in decreased expression of AXIN2 mRNA20196124
C006780bisphenol Abisphenol A affects the expression of AXIN2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of AXIN2 mRNA27685785
C006780bisphenol Abisphenol A results in decreased methylation of AXIN2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of AXIN2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of AXIN2 mRNA25181051
D002087ButyratesButyrates results in increased expression of AXIN2 mRNA16042588
D002220CarbamazepineCarbamazepine affects the expression of AXIN2 mRNA25979313
D002220CarbamazepineCarbamazepine affects the expression of AXIN2 mRNA22634333
C054133casticincasticin results in increased expression of AXIN2 mRNA27862857
C473711Chir 99021Chir 99021 inhibits the reaction [Particulate Matter analog results in decreased expression of AXIN2 mRNA]27216425
D004390ChlorpyrifosChlorpyrifos results in decreased expression of AXIN2 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AXIN2 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of AXIN2 mRNA18353800
D003024ClozapineClozapine results in decreased expression of AXIN2 mRNA16715494
D019327Copper SulfateCopper Sulfate results in increased expression of AXIN2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of AXIN2 mRNA26577399
C014347decitabinedecitabine results in decreased methylation of AXIN2 gene27923600
C014347decitabinedecitabine results in increased expression of AXIN2 mRNA27915011
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AXIN2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AXIN2 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of AXIN2 mRNA28385952
D004147DioxinsDioxins affects the expression of AXIN2 mRNA20463971
D004317DoxorubicinDoxorubicin results in increased oxidation of AXIN2 protein28818578
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of AXIN2 mRNA"23262642
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of AXIN2 mRNA28329830
C061365flusilazoleflusilazole affects the expression of AXIN2 mRNA22634333
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in increased methylation of AXIN2 mRNA22959928
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AXIN2 gene20938992
D002955Leucovorin[Methotrexate co-treated with Leucovorin] results in increased expression of AXIN2 mRNA25187349
C069837fullerene C60fullerene C60 results in increased expression of AXIN2 mRNA19167457
C056507gemcitabinegemcitabine affects the expression of AXIN2 mRNA20103597
D006220HaloperidolHaloperidol results in decreased expression of AXIN2 mRNA16715494
D006247HarmineHarmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]20519739
D017313FenretinideFenretinide results in decreased expression of AXIN2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of AXIN2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of AXIN2 mRNA26846883
C119620kenpaullone"[3,4,5,3',4'-pentachlorobiphenyl co-treated with kenpaullone] results in increased expression of AXIN2 mRNA"25711857
C119620kenpaullone"AHR2 protein affects the reaction [[kenpaullone co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of AXIN2 mRNA]"25711857
C119620kenpaulloneAHR2 protein affects the reaction [kenpaullone results in increased expression of AXIN2 mRNA]25711857
C119620kenpaullone"[kenpaullone co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of AXIN2 mRNA"25711857
C119620kenpaullonekenpaullone results in increased expression of AXIN2 mRNA25711857
D018021Lithium ChlorideLithium Chloride results in increased expression of AXIN2 mRNA22493441|2453428
D018021Lithium ChlorideNiclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]24534281
D018021Lithium ChlorideXAV939 inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]24534281
D018021Lithium Chloride[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of AXIN2 mRNA21498875
D018021Lithium ChlorideLithium Chloride results in increased expression of AXIN2 mRNA20694829|2332641
D018021Lithium ChloridePhenobarbital inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]27693619
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AXIN2 gene20938992
D008727Methotrexate[Methotrexate co-treated with Leucovorin] results in increased expression of AXIN2 mRNA25187349
D015735MifepristoneMifepristone results in increased expression of AXIN2 mRNA17584828
C523799MRK 003MRK 003 results in increased expression of AXIN2 mRNA21169257
C500085muraglitazarmuraglitazar results in decreased expression of AXIN2 mRNA21515302
D009532NickelNickel results in decreased expression of AXIN2 mRNA24768652
C028007nickel monoxidenickel monoxide results in increased expression of AXIN2 mRNA19167457
D009534NiclosamideNiclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]24534281
D009534NiclosamideNiclosamide results in decreased expression of AXIN2 mRNA22576131
D009534NiclosamideNiclosamide results in decreased expression of AXIN2 protein24552774|2473602
C015157N,N-dimethylaniline"N,N-dimethylaniline analog results in decreased expression of AXIN2 protein"21291235
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of AXIN2 mRNA26272509
D010261ParaoxonParaoxon results in decreased expression of AXIN2 mRNA24413757
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter analog results in decreased expression of AXIN2 mRNA]27216425
D052638Particulate MatterChir 99021 inhibits the reaction [Particulate Matter analog results in decreased expression of AXIN2 mRNA]27216425
D052638Particulate MatterParticulate Matter analog results in decreased expression of AXIN2 mRNA27216425
C000610380p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane inhibits the reaction [TGFB1 protein promotes the reaction [NR4A1 protein binds to AXIN2 protein]]"26929200
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AXIN2 mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of AXIN2 mRNA]19482888
D010634PhenobarbitalPhenobarbital inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]27693619
D010634PhenobarbitalPhenobarbital results in decreased expression of AXIN2 mRNA27693619
D010634PhenobarbitalPhenobarbital results in increased expression of AXIN2 mRNA19482888
D010705PhosgenePhosgene affects the expression of AXIN2 mRNA16300373
C006253pirinixic acidpirinixic acid results in decreased expression of AXIN2 mRNA17426115
C548732PKF118-310PKF118-310 results in decreased expression of AXIN2 mRNA22470504
D010936Plant ExtractsPlant Extracts results in increased expression of AXIN2 mRNA23262642
D011192Potassium DichromatePotassium Dichromate results in increased expression of AXIN2 mRNA23608068
D017035PravastatinPravastatin results in decreased expression of AXIN2 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of AXIN2 mRNA27225895
D011374ProgesteroneProgesterone results in decreased expression of AXIN2 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of AXIN2 mRNA20660070
C024631pyrviniumpyrvinium results in decreased expression of AXIN2 mRNA21170416
D011794QuercetinQuercetin results in decreased expression of AXIN2 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]23117658
D011794QuercetinQuercetin inhibits the reaction [Warfarin results in increased expression of AXIN2 mRNA]23117658
C059514resveratrolresveratrol results in decreased expression of AXIN2 mRNA21188121
C059514resveratrolresveratrol results in decreased expression of AXIN2 protein21291235
C059514resveratrolresveratrol results in decreased expression of AXIN2 mRNA22935447
C059514resveratrolresveratrol results in decreased expression of AXIN2 protein22935447
C059514resveratrolresveratrol results in increased expression of AXIN2 mRNA23848300
C089730rosiglitazonerosiglitazone results in decreased expression of AXIN2 mRNA21515302
C417521SB 216763SB 216763 results in increased expression of AXIN2 mRNA19228266|1944813
D012822Silicon DioxideSilicon Dioxide analog affects the expression of AXIN2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AXIN2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of AXIN2 mRNA27095093
D019821SimvastatinSimvastatin affects the expression of AXIN2 mRNA19968183
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in increased methylation of AXIN2 mRNA22959928
C075117squalestatin 1squalestatin 1 affects the expression of AXIN2 mRNA27225895
C075117squalestatin 1squalestatin 1 affects the expression of AXIN2 mRNA27225895
C501413tesaglitazartesaglitazar results in decreased expression of AXIN2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AXIN2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of AXIN2 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AXIN2 mRNA18796159|1993321
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of AXIN2 mRNA21602191
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AXIN2 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of AXIN2 mRNA20530235
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of AXIN2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AXIN2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of AXIN2 mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of AXIN2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AXIN2 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AXIN2 gene25560391
D014812Vitamin KQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]23117658
D014812Vitamin K[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA23117658
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AXIN2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of AXIN2 mRNA26272509
D014859WarfarinQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]23117658
D014859WarfarinQuercetin inhibits the reaction [Warfarin results in increased expression of AXIN2 mRNA]23117658
D014859Warfarin[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA23117658
D014859WarfarinWarfarin results in increased expression of AXIN2 mRNA23117658
C544261XAV939"[3,4,5,3',4'-pentachlorobiphenyl co-treated with XAV939] results in increased expression of AXIN2 mRNA"25711857
C544261XAV939"[XAV939 co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of AXIN2 mRNA"25711857
C544261XAV939XAV939 results in decreased expression of AXIN2 mRNA25711857
C544261XAV939XAV939 inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]24534281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10698523  16815967  17510365  22056988  24251807  25873176  
GO:0008013beta-catenin binding-NAS11017067  
GO:0019899enzyme binding-IPI19759537  21383061  21478859  
GO:0031625ubiquitin protein ligase binding-IPI21478859  
GO:0070411I-SMAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001756somitogenesis-IEA-  
GO:0001934positive regulation of protein phosphorylation-IMP20300119  
GO:0003139secondary heart field specification-IEA-  
GO:0003413chondrocyte differentiation involved in endochondral bone morphogenesis-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0008285negative regulation of cell proliferation-IMP16247484  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP17072303  
GO:0010942positive regulation of cell death-IMP16247484  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030282bone mineralization-IEA-  
GO:0032423regulation of mismatch repair-IMP11017067  
GO:0034613cellular protein localization-IDA17072303  
GO:0042476odontogenesis-IMP15042511  16432638  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0043570maintenance of DNA repeat elements-IMP18755497  
GO:0048255mRNA stabilization-IMP17072303  
GO:0061181regulation of chondrocyte development-IEA-  
GO:0070602regulation of centromeric sister chromatid cohesion-IMP20300119  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA11940574  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP11017067  16247484  
GO:0090263positive regulation of canonical Wnt signaling pathway-TAS-  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12072559  21383061  
GO:0005737cytoplasm-IDA21383061  
GO:0005813centrosome-IDA20300119  
GO:0005829cytosol-TAS-  
GO:0030877beta-catenin destruction complex-NAS11017067  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4411364Binding of TCF/LEF:CTNNB1 to target gene promotersTAS
R-HSA-4641257Degradation of AXINTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21472303AXIN2 polymorphism and its association with astrocytoma in a Turkish population. (2010 Jul-Aug)Gunes EGMol Med Rep
22207181Epigenetic and genetic analysis of WNT signaling pathway in sporadic colorectal cancer patients from Iran. (2012 May)Naghibalhossaini FMol Biol Rep
21475939Strong association between lung cancer and the AXIN2 polymorphism. (2009 Nov-Dec)Gunes EGMol Med Rep